fibroblast growth factor 15
Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
... Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hor- ...Keywords: Fibroblast growth factor 15/19, ...
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Fibroblast growth factor 2 orchestrates angiogenic networking in non GIST STS patients
... VEGFR-3 is classically associated with lymphangiogen- esis, but has recently been linked to angiogenesis [28,29]. Using the mouse corneal assay, Kubo et al. found FGF2 induced angiogenesis to be blocked by administration ...
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Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
... Serum-starved NIH 3T3 cells were stimulated for 15 minutes with 1, 10, or 100 ng/mL FGF1 V or FGF1 V –vcMMAE in the presence of heparin (10 U/mL). The cells were then washed with PBS, lysed with SDS sample buffer, ...
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Sleeve gastrectomy attenuates high fat diet-induced non-alcoholic fatty liver disease
... Fibroblast growth factor 21 (FGF21), a member of the fibroblast growth factor family, has emerged as a leading candidate in the regulation of energy homeostasis, glucose-lipid ...
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Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
... Basic fibroblast growth factor (bFGF), a neurotrophic factor, can play the part of a crucial regulator for neuroprotection, neurogenesis and angiogenesis from various insults ...Nerve ...
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Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Hemodialysis Patients
... This is an observational and prospective cohort study. The subjects of this study were treated in the dialysis center of Towa Hospital (Tokyo, Japan). Each patient underwent HD three times weekly (4 hours/day). Blood ...
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VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis
... endothelial growth factor (VEGF), epidermal growth fac- tor (EGF), and fibroblast growth factors 1 and 2 (FGF1 and FGF2) are powerful mitogens and play a central role in the initiation ...
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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
... FGF2 utilizes HSPGs, such as syndecans (SDC), as binding partners to stabilize the FGF-FGFR interaction and enhance resistance to proteolysis [15, 16]. FGF2 cannot activate FGFRs in cells lacking heparan sulfate ...
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Potent mitogenic effects of parathyroid hormone (PTH) on embryonic chick and rabbit chondrocytes Differential effects of age on growth, proteoglycan, and cyclic AMP responses of chondrocytes to PTH
... to 15-fold increase in the efficiency of colony formation in soft agar by chondrocytes from embryonic 13- to 19-d-old chickens and fetal 25-d-old rabbits with a 10-fold increase in their DNA ...PTH: ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... were dissected out, olfactory bulbs and meninges were removed. Cortical hemispheres were then transferred to a new 60 mm dish containing 5 mL cold HBSS on ice. Cortices were minced with a razor blade and transferred to a ...
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Intrauterine growth restriction and placental angiogenesis
... VEGF, one of the first angiogenic factors identified, is widely believed to be the most important regulator of both normal and pathological angiogenesis [15]. It plays an essential role in the formation of new ...
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Caries Induced FGF 2 Expression in Human Dental Pulp
... regulatory factor in the control of vascular permeability and angiogenesis (Ferrara et ...endothelial growth factor is originally a basic 45-kDa heparin-binding ...derived growth factor ...
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Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis
... randomized, double-blind, 52-week, Phase III trials (INPUL- SIS-1 and INPULSIS-2). The eligibility criteria for IPF patients more than 40 years old were identical to those of the TOMORROW trial: FVC that was $50% of ...
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Initiation of vertebrate limb development
... in Fibroblast growth factors (FGFs) and placed in prospective flank of chick embryos induce formation of ectopic limb buds, which contain their own signaling regions and develop into complete ...
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The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
... endothelial growth factor (VEGF), a dimeric 46-kDa gly- coprotein, is an endothelial cell-specific, multifunctional ...Platelet-derived growth factor (PDGF) has angiogenic effects and stimu- ...
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Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot
... The stromal vascular fraction is an active component in adipose tissue and contains a variety of cells including adipose stem cells [10]. Since the various cell types, they have strong regenerative potentials such as ...
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Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis
... the growth and progression of KS and since PAF can activate vascular endothelial cells, we examined the potential role of PAF as an instrumental mediator of angiogenesis associated with ...
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The importance of antiangiogenic effect in multiple myeloma treatment
... Angiogenesis plays a significant role in oncogenesis, and thus it has become an attractive target for cancer treatment. It is the formation of new blood vessels that occurs physiologically as well as under pathological ...
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Targeting tumor-associated macrophages to combat pancreatic cancer
... Apart from VEGF, HIF-1α, and TGF-β, angiopoietin-2 (Ang-2), a ligand of the Tie2 tyrosine kinase receptor, has also been reported to be involved in TAM-regulated angiogenesis in tumor microenvironment (Figure 2). ...
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Neuron Like Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
... When BMSCs proliferate and differentiate, as we discov- ered in the immunohistochemical stain positive ratio of the two groups, one treated with EGF only and the other with both EGF and HGF, it is our understanding that ...
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