Fine specificity
The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity
... the fine specificity of the antibody response, defined as the relative response to individual epitope regions of the CS antigen, is associated with opsoniza- tion activity and ...
12
Aluminum Hydroxide Influences Not Only the Extent but Also the Fine Specificity and Functional Activity of Antibody Responses to Tick-Borne Encephalitis Virus in Mice
... antibody fine specificity ob- served in our study are likely a consequence of antigen adsorption to aluminum hydroxide, which has been shown to be crucial for its adjuvant effect (3, 4, ...
9
Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies.
... 2 0022-538X/93/020703-08$02.00/0 Copyright C 1993, American Society for Microbiology Fine Specificity of the Human Immune Response to the Major Neutralization Epitopes Expressed on Cytom[r] ...
8
ACPA fine specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression
... The diagnosis of RA relies in part on the detection of ACPA, for example, by the most commonly applied cyc- lic citrullinated peptide 2 (CCP2) test [10]. It has been demonstrated that ACPAs are already present prior to ...
10
Molecular Fine Specificity Analysis of Antibody Responses to Human Cytomegalovirus and Design of Novel Synthetic Peptide Based Serodiagnostic Assays
... molecular fine specificity of antibody responses in different individuals with latent or active human cytomegalovirus (HCMV) ...epitope fine specificity of the antibody response was determined ...
10
The fine specificity of IgM anti citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
... the fine specificity of IgM and IgG ACPAs in 113 ACPA-positive rheumatoid arthritis patients with IgM cyclic citrullinated peptide 2 (CCP2) levels above 100 ...AU/ml. Fine specificity was ...
7
Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non polymorphic domains
... The intrinsically unstructured D and C offers an ideal opportunity to study the fine specificity of MSP2-reactive human Abs using long and/or short overlapping peptides. The lengths of different LSPs ...
13
Immunization with Immune Complexes Modulates the Fine Specificity of Antibody Responses to a Flavivirus Antigen
... To test whether the dissociation effect mediated by MAb A3 required bivalent binding to sE, we conducted a similar experi- ment with the A3 Fab fragment and—as a control—the Fab frag- ment of the nondissociating MAb B4 ...
9
Passively Transmitted gp41 Antibodies in Babies Born from HIV-1 Subtype C-Seropositive Women: Correlation between Fine Specificity and Protection
... Since all mothers received the same preventive antiretroviral therapy during delivery in a single dose and the babies were born within 12 to 18 h of their mothers receiving drug, it was unlikely that NVP was present in ...
10
Genetic control and fine specificity of the immune response to a synthetic peptide of influenza virus hemagglutinin.
... More recently, we have examined the binding of monoclonal antibodies and immune serum from BALB/c mice to comprehensive sets of overlapping peptides of different lengths covering the seq[r] ...
7
Fine specificity of anti MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub microscopic infection
... The fine speci- ficity of such functional antibodies may be examined using a numbers of methods including direct binding to antigen or modified antigen [19,20] or competition assays using defined mAbs ...
9
Fine specificity of cellular immune responses in humans to human cytomegalovirus immediate-early 1 protein.
... Therefore, prior to doing functional studies of the possible role of these cells in humans, we investigated whether CD4+ T cells specific for the IE1 protein were present in normal serop[r] ...
9
Characterization of fine specificity of the immune response to a Plasmodium falciparum rhoptry neck protein, PfAARP
... b Splenic cells from protein immunized mice were stimulated with peptides and IFN-γ secretion in the culture supernatant was analysed by ELISA to evaluate T cell epitopes; stimulation wi[r] ...
14
Synthetic peptides define the fine specificity of the human immunodeficiency virus (HIV) gp160 humoral immune response in HIV type 1-infected chimpanzees.
... KENNEDY'* Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78284,1 and Department of Medicine, Wilford Hall USAF Medical Center, La[r] ...
7
Complement Component C1q Enhances the Biological Activity of Influenza Virus Hemagglutinin-Specific Antibodies Depending on Their Fine Antigen Specificity and Heavy-Chain Isotype
... Ab’s fine specificity (antigenic region Cb/E > Ca/A,D > Sa,Sb/B), its heavy-chain isotype (immunoglobulin G2 [IgG2] > IgG3; IgG1 and IgM negative), and to some extent also on its derivation ...
10
Impact of pre existing MSP142 allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine
... Induction of potent humoral immune responses requires the engagement of an efficacious T helper cell response. Evidence in the literature suggests a direct in- volvement of effector T cells in protection against blood ...
15
Popular and unpopular infectious agents linked to primary biliary cirrhosis
... Shigematsu H, Shimoda S, Nakamura M et al (2000) Fine specificity of T cells reactive to human PDC-E2 163-176 pep- tide, the immunodominant autoantigen in primary biliary cir- rhosis: im[r] ...
10
A specific anti citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll like receptor 4 mediated disease
... ACPA fine specificity assays RASF were characterized for levels of ACPA (commercial anti-cyclic citrullinated peptide (CCP)-2 ELISA, Eurodiag- nostica), HMGB1, and S100A8/A9 using commercial ELISA kits ...
12
The influence of autoantibody status and characteristics on the course of rheumatoid arthritis
... In the previously mentioned studies we investigated to role of the IgG ACPA fine specificity repertoire. As IgM producing memory B cells have not been described, the presence of IgM ACPA suggests that ...
215
Induction of immune response to influenza virus with anti-idiotypic antibodies.
... We show that neutralizing antibody specific for influenza virus can be induced in mice by immunization with anti-Id antibodies, and we examine the fine specificity of the antiviral antib[r] ...
10