Fitness Costs
Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs
... with fitness costs and that the antiviral effect of HLA-B*08-restricted T cells is sufficiently strong to force the virus to adopt a relatively unfavorable ...
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Epistasis analysis uncovers hidden antibiotic resistance associated fitness costs hampering the evolution of MRSA
... As fitness costs associated with antibiotic resistance can be offset in many ways by bacteria, we hypothesised that perhaps there is a cost to becoming mup R , but the associated reduction in the production ...
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Fitness costs associated with Cry1F resistance in the European corn borer
... refuges, fitness costs of Bt resistance can delay the evolution of ...Importantly, fitness costs often vary with ecological factors, including host-plant genotype and ...examined ...
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Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps
... Fitness costs associated with the overexpression of efflux pumps could be the result of two aspects inherent in their mechanism: the constant extrusion of metabolic intermediates that are the natural ...
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Preexisting compensatory amino acids compromise fitness costs of a HIV 1 T cell escape mutation
... Background: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 ...the ...
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In Vivo Fitness Costs of Different Gag CD8 T-Cell Escape Mutant Simian-Human Immunodeficiency Viruses for Macaques
... However, fitness costs are likely to occur following most immune escape mutations, as is most clearly demonstrated when escaped viruses revert upon transmission to major histocompatibility complex ...
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Fitness Costs Limit Viral Escape from Cytotoxic T Lymphocytes at a Structurally Constrained Epitope
... that fitness costs can limit the evolution of CTL epitope ...the fitness costs associated with viral escape from p11C, C-M-specific CTL, we constructed a panel of viruses encoding point ...
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Extremely fast amelioration of plasmid fitness costs by multiple functionally diverse pathways
... © The Authors, 2019. The definitive peer reviewed, edited version of this article is published in Hall, J.P.J., Wright, R.C.T., Guymer, D. et al. (2 more authors) (2019) Extremely fast amelioration of plasmid ...
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Fitness costs associated with Cry1F resistance in the European corn borer
... of fitness costs associated with Bt resistance may be affected by host- plant quality (Gassmann et ...of fitness costs of resistance can delay resistance to Bt crops in insect populations, and ...
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Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins
... escape-associated fitness costs by utilizing a well-described pro- tein folding energy algorithm, FOLDEF (for FOLD-X Energy Function) (51), which can estimate the Gibbs free energy of fold- ing ( ⌬ G) and ...
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Absolute Measurements of mRNA Translation in Caulobacter crescentus Reveal Important Fitness Costs of Vitamin B12 Scavenging
... ABSTRACT Caulobacter crescentus is a model for the bacterial cell cycle which cul- minates in asymmetric cell division, yet little is known about the absolute levels of protein synthesis[r] ...
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Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs
... cell culture are frequently also found in HIV-1-infected individuals (35–37). However, T20 and Maraviroc act by mechanisms that are different from that of VIRIP. Resistance to T20 has a low genetic barrier and just ...
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Reduced Fitness Costs of mcr-1.2 Compared to Mutated pmrB in Isogenic Colistin-Resistant KPC-3-Producing Klebsiella pneumoniae
... ABSTRACT In the present study, we provide the results of a detailed genomic analysis and the growth characteristics of a colistin-resistant KPC-3-producing Klebsiella pneu- moniae sequence type 512 (ST512) isolate (the ...
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Clinically Relevant Plasmid Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase Carrying Plasmids
... fitness costs, and plasmids maintained in certain well-adapted hosts may provide a plasmid reservoir ...fitness costs are associated with plasmid carriage, both mathematical models and experimental evidence ...
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Fitness costs associated with evolved herbicide resistance alleles in plants
... Resistance cost of a cytochrome P450 herbicide metabolism mechanism but not an ACCase target site mutation in a multiple resistant Lolium rigidum population.. Vila-Aiub MM, Neve P, Powle[r] ...
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Fitness Costs and Variation in Transmission Distortion Associated with the Abnormal Chromosome 10 Meiotic Drive System in Maize
... To better understand the evolution of the Ab10-driving chromosome in maize, we measured the level of drive in nine Ab10 haplotypes. The results reveal variable, but large, seg- regation advantages through ovules in the ...
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Fitness Costs of Mutations Affecting the Systemic Acquired Resistance Pathway in Arabidopsis thaliana
... the fitness effects of four mutations (npr1, cpr1, cpr5, and cpr6) and two transgenic genotypes (NPR1-L and NPR1-H) affecting different points of the systemic acquired resistance (SAR) signaling pathway associated ...
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Fitness costs may explain the post colonisation erosion of phenotypic plasticity
... mean fitness, so why is it not more common? Plausibly, adaptive plasticity also confers a cost; reshaping the phenotype takes time and energy, so that canalised control of trait values enhances fitness if ...
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Immune system responses and fitness costs associated with consumption of bacteria in larvae of Trichoplusia ni
... Immune response costs of resistance, avoidance and toler- ance towards pathogens can differ [7,32]. Ideally, depend- ing on the probability and nature of microbes encountered in the environment, different host ...
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Wolbachia strain w AlbB confers both fitness costs and benefit on Anopheles stephensi
... host fitness associated with Wolbachia is one of the key factors that determines the population dynamics following its field ...a fitness cost and benefits in ...LB1 fitness data reported here could ...
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