FLT3-ITD mutation in AML
Comparison of FLT3 inhibitors with the standard treatment for FLT3-ITD mutated acute myeloid leukemia
... with FLT3-ITD mutated AML but there are still challenges and opportunities for ...the FLT3-ITD ...the FLT3-ITD mutation in AML and to sustain the inhibition, ...
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Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model
... kinase, FLT3/ITD portends a particularly poor prognosis, with reduced overall survival and increased rates of ...endogenous Flt3 locus, which develops a fatal myeloproliferative neoplasm (MPN), but ...
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Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML
... that FLT3-ITD expressing AML patient samples and cell lines express the NOX4D 28 kDa splice ...variant. FLT3-ITD expressing AML cells express NOX4D in the nuclear membrane, which ...
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Cytogenetics and FLT3-ITD mutation predict clinical outcomes in non transplant patients with acute myeloid leukemia
... CEBPA mutation are considered to be the favorable prognostic risk stratification for AML, whereas high allele burden of FLT3-ITD mutation with or without mutant NPM1 is classified as ...
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FLT3 Mutations: Significance in Paediatric AML
... mentioned, FLT3 mutations are the most common and clinically relevant mutations in AML, contributing to around one-third of the ...of FLT3 receptor ...of FLT3 receptor, which results in the ...
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FLT3-ITD Negative Refractory/Relapsed or Geratic AML Patients Responded Well to Salvage Treatment with Low Dose Cytarabine and Sorafenib
... these AML patients achieving CR until adverse event happening or stem cell transplantation ...geratic AML patients unfit for intensive chemotherapy induction and without FLT3-ITD ...
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The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells
... 11 a better alternative to suspension culture for modeling responses to cytotoxic agents(5, 28). The Molm14 cell line is an AML cell line derived from a patient harboring a FLT3/ITD ...
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CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... from AML patients with intermediate-risk cytogenetics, high levels of CDC25A mRNA were predictive of higher clonogenic potential in FLT3-ITD+ samples, not in FLT3-wt ...of ...
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Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia
... of FLT3-ITD positive AML blasts and AML cell ...induced AML blast proliferation and downstream AKT and MAPK signalling pathways 9 ...whether FLT3-ITD mutated primary ...
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Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature
... Normal AML In order to define the specific genomic targets of aberrant signaling in KN AML with the FLT3-ITD mutation, we purified un- differentiated CD34 or CD117 positive cells, or ...
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Chronic FLT3 ITD signaling in acute myeloid leukemia is connected to a specific chromatin signature
... Normal AML In order to define the specific genomic targets of aberrant signaling in KN AML with the FLT3-ITD mutation, we purified un- differentiated CD34 or CD117 positive cells, or ...
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Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.
... in AML cells using a combination of curcumin and carnosic acid, however the authors did not test AML cells with the FLT3/ITD mutation, so it is unknown if this strategy has greater ...
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<p>Acute myeloid leukemia patient with <em>FLT3-ITD</em> and <em>NPM1</em> double mutation should undergo allogeneic hematopoietic stem cell transplantation in CR1 for better prognosis </p>
... of FLT3-ITD ...When FLT3-ITD ’ s AR is low, AML FLT3-ITD+/NPM1+ falls to low risk, when FLT3-ITD ’ s AR is high, this type of AML falls to ...
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Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress
... positive cells. The combinatorial effects of Gilteritinib plus ATO on cell proliferation, apoptosis assay, morpho- logic assessment, transwell assay and cell cycle analysis were examined. We also estimated the ...
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Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia. Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom
... of FLT3-ITD positive AML blasts and AML cell ...induced AML blast proliferation and downstream AKT and MAPK signalling pathways 9 ...whether FLT3-ITD mutated primary ...
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Cooperation between the partial tandem duplication of Mll (Mll PTD) and internal tandem duplication of FLT3 (FLT3 ITD) in the pathogenesis of acute myeloid leukemia AML
... and FLT3 ITD in leukemogenesis In unselected cases of AML, a higher incidence of MLL PTD in FLT3 ITD positive patients was significantly higher than in FLT3 ITD negative ...
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Frequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
... Different FLT3 activating mutations have been detected, but two types are more common as described in detail previously [3, 10]; 1) internal tandem duplication (ITD) which is seen in 15- 35% of adult ...
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Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients
... of FLT3 mutational screening [6, 22, ...of FLT3 ITD during the disease course, with cases evolving from FLT3 ITD- to FLT3 ITD+ and viceversa [10, ...of FLT3 ...
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Impact of FLT3-ITD length on prognosis of acute myeloid leukemia
... of FLT3-ITD length on prognosis of acute myeloid leukemia Song-Bai Liu, 1* Hao-Jie Dong, 2* Xie-Bing Bao, 3,4,5* Qiao-Cheng Qiu, 3,4,5* Hong-Zhi Li, 6 Hong-Jie Shen, 3,4,5 Zi-Xuan Ding, 3,4,5 Chao Wang, ...
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Patients with FLT3-mutant AML Needed to Enroll on FLT3-Targeted Therapeutic Clinical Trials
... of AML, particularly early-phase studies, with targeted or nonspecific ...both FLT3 inhibitor trials and trials of other targeted ...to FLT3 inhibitor trials, we note that before the approval of ...
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