FLT3-ITD
An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
... The pMIG plasmid containing human FLT3- ITD was previously described [34]. For retrovirus production, 6 µg pMIG-FLT3-ITD or empty vector were transfected into Phoenix E cells using ...
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Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
... in FLT3-ITD expressing MV4-11 cells significantly inhibited the directed trans-well migration towards FCS which contains lysophosphatidic acid (LPA) as a major ...in FLT3- ITD positive ...
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Chronic FLT3 ITD signaling in acute myeloid leukemia is connected to a specific chromatin signature
... mutated FLT3 growth factor receptor to the nucleus and demon- strates a profound impact of aberrant signaling on transcription factor binding and FLT3-ITD-specific gene ...aberrant ...
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Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature
... the FLT3 transmembrane domain as a paradigm. FLT3-ITD mutations are found in 25% of KN-AML and lead to constitutive activation of the downstream mitogen-activated protein kinase (MAPK), AKT, and ...
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FLT3-ITD Negative Refractory/Relapsed or Geratic AML Patients Responded Well to Salvage Treatment with Low Dose Cytarabine and Sorafenib
... As a primary study on sorafenib treatment of AML patients without FLT3-ITD mutation, there are obvious shortcomings in this report. First, the relationship of c-Kit mutation and sorafenib responses in our ...
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Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model
... After determining that Dnmt3a loss and the Flt3/ ITD mutation do indeed cooperate to greatly expand the LT-HSC pool, we sought to investigate the mechanism underlying this observation. To assess ...
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<p>Long Noncoding RNA SOCS2-AS Promotes Leukemogenesis in FLT3-ITD+ Acute Myeloid Leukemia Through miRNA-221</p>
... Acute myeloid leukemia (AML) is a malignant hematological disease caused by uncontrolled proliferation, blocked apoptosis and dysdifferentiation of bone marrow hematopoietic stem cells. 1 The mutation of FMS-like ...
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CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... type FLT3, upon different culture conditions, including stimulation by GM-CSF, IL-3 or G-CSF (Supplementary Figure ...in FLT3-ITD positive cell lines (Supplementary Figure S2c and S2d), suggesting ...
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FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia
... expressing FLT3-ITD, in accordance with a previous report ...expressing FLT3-ITD, ...by FLT3-ITD may play a role in acquisition of the resistance to the PI3K/Akt pathway ...
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Cytogenetics and FLT3-ITD mutation predict clinical outcomes in non transplant patients with acute myeloid leukemia
... wild-type FLT3-ITD (p = ...and FLT3- ITD positive AML in the univariate analysis, however, they were not found to be independently significant in multivariate ...type FLT3-ITD ...
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Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
... with FLT3 ITD had the highest DUSP6 protein ex- pression, however, wildtype FLT3 expressing cells also showed increased DUSP6 protein levels when compared to parental 32D cells, possibly caused by ...
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<p>Profile of Quizartinib for the Treatment of Adult Patients with Relapsed/Refractory FLT3-ITD-Positive Acute Myeloid Leukemia: Evidence to Date</p>
... the FLT3 kinase ...to FLT3 relies on edge-to-face aromatic interac- tions mediated by the gatekeeper residue, F691, and activation loop ...the FLT3-quizartinib complex further suggests that once the ...
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Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones
... of FLT3/ITD mutations at ...the FLT3/ITD mutations are present only in subclones derived from the original LSC, subclones that lack the capacity for ...Alternately, FLT3 mutations could ...
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Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients
... increase FLT3 ITD detection sensitivity of the routine RT-PCR assay ...were FLT3 ITD- at diagnosis and relapsed as FLT3 ITD+, actually had a small original FLT3 ...
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Melatonin enhances sorafenib-induced cytotoxicity in FLT3-ITD acute myeloid leukemia cells by redox modification
... ROS might function as a double-edged sword. Previous reports have demonstrated that adequate amount of ROS is essential for regulation of physiological event, while excessive production could lead to cell death [27, 30, ...
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Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
... in FLT3-ITD AML is complex. FLT3-ITD cells have high baseline ROS levels [50] which are associated with increased DNA ...in FLT3-ITD cells also inactivate the protein tyrosine ...
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T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3 -ITD mutated acute myeloid leukemia
... in FLT3-ITD mutated AML cells in comparison to FLT3-wt AML cells, we performed gene expression microarray analysis in FLT3-ITD mutated MV4-11 cells transfected with TOPK-siRNA or ...
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Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress
... of FLT3 TKIs like Crenolanib and ...on FLT3-ITD/D835Y mutation than Quizartinib [38] and the therapeutic effect of Crenolanib at the maxi- mum tolerable dose is limited compared to Gilteritinib in ...
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Frequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
... no FLT3 mutation either TKD or ITD was found in the study ...14.4% ITD and 4.1 %TKD [21]; ALL, 1.3% ITD and ...3.4% ITD and 1.14%TKD [23]; and MDS, 0.71% ITD and ...
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Emerging therapies for acute myeloid leukemia: translating biology into the clinic
... the FLT3 receptor tyrosine ...AML, FLT3 and its inhibitors are most advanced. FLT3 encodes a receptor tyrosine kinase containing a characteristic interrupted kinase domain ...1). FLT3 is ...
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