focal ischemia
Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery
... Dalkara, “VEGF protects brain against focal ischemia without increasing blood-brain permeability when administered intracerebroventricularly,” Journal of Cerebral Blood Flow & Metabolism[r] ...
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The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury
... after focal ischemia [76–79] ...of ischemia with 6 h of reperfusion, whereas BBB disruption was only found with longer (60 min) periods of ...
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Perspective of synaptic protection after post infarction treatment with statins
... In focal ischemia, the region that suffers the most se- vere degree of hypoperfusion progresses rapidly towards irreversible damage due to a necrotic death, which rep- resents the ischemic core ...bral ...
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Heme Oxygenase-2 Is Neuroprotective in Cerebral Ischemia
... In the present study, we demonstrate that neural damage following middle cerebral artery occlusion (MCAO), a model of focal ischemia of vascular stroke, is substantially worsened in HO2 [r] ...
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Caspase-3-Dependent and -Independent Apoptosis in Focal Brain Ischemia
... brain ischemia produced in neonatal rat, 7 days postpartum ...the focal ischemia of adult brain is not clear, as the levels of caspase-3 diminish markedly 2 weeks after birth, and in adult rat brain ...
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The Search for Neuroprotective Strategies in Stroke
... Experimental studies frequently use only male an- imals to reduce variability between mixing sexes and avoid having to account for the estrus cycle in exper- imental design. Recent data have established sex dif- ferences ...
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Research Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
... for focal ischemia in animal models are very different because of various variables and varia- tion in ...larger ischemia, especially in the hippocampal and hypothalamic areas ...
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VEGF induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
... VEGF and neuroprotection in ischemic brain. At least four previous studies have examined the effect of VEGF on cerebral infarct size. Hayashi et al. (12) applied VEGF topically to the surface of the rat brain after 90 ...
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Reperfusion brain injuryFocus on cellular bioenergetics
... The imbalance of the brain bioenergetics induced by the loss of blood flow has been shown to lead to cellular infarction of all brain cells, including neurons, astrocytes, endothelial cells, oligodendrocytes, and ...
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Focal cerebral ischemia in the TNFalpha-transgenic rat
... Quantification of apoptotic cell death by DNA frag- mentation in TNFα-transgenic and non-transgenic rat brain after focal ischemia. The bar graph shows DNA fragmentation representing apoptotic cell death in ...
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Role of Cerebrovascular Abnormality in Neurodegenerative Disease and Subcortical Ischemic Disease: CT Perfusion and PET Imaging
... after focal ischemia can be one of the driving causes leading to this chronic ...post ischemia (chapter 4), because in our animal model CI was also induced in the subcortical location ...
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Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
... All animals studied had visible ischemic lesions in the MCA territory after 1 h ischemia and 6 h of reperfusion (earliest time point studied). There was a significant increase in cortical infarct volume over the ...
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Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats
... China. Focal cerebral ischemia was induced by MCAO (the suture method) for 2 hours in male rats (Sprague-Dawley, 250–280 g) under anesthesia (20% chloral hydrate, body temperature ...the ischemia ...
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VEGF enhances angiogenesis and promotes blood brain barrier leakage in the ischemic brain
... surrounding focal brain infarcts (4, 5) and that stroke patients with a higher blood vessel density in the ischemic penumbra appear to have better progress and longer survival (3), indicting that restoration of ...
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Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal
... transient focal cerebral ischemia in mice, but also that ischemic post-conditioning facilitates transplantation of neural progenitor cells (NPCs) leading to sustained neurological recovery (Doeppner et ...
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The role of rutin in focal cerebral ischemia: oxidative stress factors and rotarod test
... cerebral ischemia or at the onset of reperfusion has shown a reduction of ischemic neural apoptosis by increasing endogenous antioxidant enzymatic activities in experimental animals ...
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Original Article Mild hypothermia combined with isoflurane post-treatment alleviates cerebral ischemia reperfusion injury in rats through inhibition of STAT3 activation
... Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process, and the injury mechanisms associated are various, involves toxicity of excitatory amino acid [15], inflammatory reaction [16], ...
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The immune response after hypoxia-ischemia in a mouse model of preterm brain injury
... HI-induced injury to the immature brain has been found to induce the expression of various genes related to im- mune responses and inflammation, including macrophage and microglia-related genes, T-lymphocyte–related ...
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Original Article Activation of STAT3 is involved in neuronal apoptosis in focal cerebral ischemia/reperfusion rats via Bcl 2/Fas pathway
... sient focal cerebral ischemia [9, ...in focal cerebral ischemia/reperfusion rats remains ...in focal cerebral ischemia ...
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Original Article Baicalin protects against thrombin induced cell injury in SH-SY5Y cells
... [10, 11]. PARs are a family of seven transmem- brane G protein-coupled receptors that include PAR-1, PAR-2, PAR-3 and PAR-4. Of these differ- ent receptors, PAR-1, PAR-3, and PAR-4 can be activated by thrombin, whereas ...
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