Folate Receptor
Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance Daniel J. O’Shannessy 1, Gordon Yu3 , Robert Smale 5, Yao-Shi Fu5 , Sunil Singhal 4 Robert P. Thiel 6, Elizabeth B. Somers1 , and Anil Vachani 2
... towards folate receptor alpha, with several such agents in late stage clinical development, the sensitive and robust detection of folate receptor alpha in tissues is of importance relative to ...
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Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate
... targeting folate receptor alpha (FRα)-positive cancer cells [4] attached to a highly potent cytotoxic maytansinoid, DM4 ...only folate receptor targeting therapeutic approach currently ...
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Targeting folate receptor alpha for cancer treatment
... Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen ...
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Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats
... their folate (folic acid) using re- duced folate carriers and/or the proton-coupled folate transporter, which are needed for normal cell survival and proliferation [21, ...tion, folate uptake ...
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Folate receptor-targeted fluorescent paramagnetic bimodal liposomes for tumor imaging
... objective: Receptor-targeted delivery of imaging and therapeutic agents can lead to enhanced efficacy for ...marker folate receptor (FR)-targeted fluorescent paramagnetic bimodal liposomes were ...
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SPECIFIC TARGETING OF FOLATE RECEPTOR BY METHOTREXATE CONJUGATED MODIFIED MAGNETIC NANOPARTICLES: ENZYMATIC RELEASE AND CYTOTOXIC STUDY
... ABSTRACT: Magnetic nanocarriers have been used for specific drug delivery to release therapeutic drugs into target cancer cells. We used bifunctional methotrexate (MTX) conjugated magnetic nanoparticles (MNPs) (~37 nm) ...
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Original Article Folate receptor alpha promotes endometrial carcinoma cell proliferation and inhibits apoptosis by regulating the ERK signaling pathway
... Endometrial carcinoma (EC) is a type of epithe- lial endometrial malignant tumor that occurs in the endometrium. It has various histologic typ- es, of which endometrial adenocarcinoma (EA) is the most common [1]. The ...
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Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine
... detect folate receptor expression in tissue samples and cell lines of head and neck squamous carcinoma, including 20 tissue samples of nasopharyngeal carcinoma, 16 tissue samples of laryngeal carcinoma, and ...
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Lack of Association between Folate Receptor Autoantibodies and Neural Tube Defects
... The final study set of 300 samples consisted of those from 103 case mothers, 103 matched-control mothers, 58 women who had never been pregnant, and 36 men. Case and control blood samples were coded, identifying ...
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Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism
... Furthermore, folate molecules were linked to the FITC-doped silica NPs by using polyethylene glycol (PEG) (NH2-PEG-maleimide) as a spacer, thus forming folate receptor targeting fluorescent NPs, ...
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Regulation of the cytoplasmic accumulation of 5 methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation
... the folate receptor (also known as the membrane folate binder) is able to deliver 5-methyltetrahydrofolic acid to the cytoplasm of folate-depleted MA104 cells, we have examined the kinetics of ...
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Evaluation of the novel folate receptor ligand [18F]fluoro PEG folate for macrophage targeting in a rat model of arthritis
... FR receptor blockade with glucosamine-folate, suggesting specific receptor binding of the ...the folate conjugate EC20 was noted in rats with adjuvant induced arthritis compared to normal rats ...
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Targeted treatment of folate receptor-positive platinum-resistant ovarian cancer and companion diagnostics, with specific focus on vintafolide and etarfolatide
... of folate receptor-α on the surface of almost all epithelial ovarian cancers makes this receptor an excellent “tumor-associated ...spacers/linkers, folate-targeted drugs can be distributed ...
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Assessment of folate receptor-β expression in human neoplastic tissues
... the folate receptor has recently been shown to be expressed on tumor-associated macrophages [9, 10, 23], the only reports of FR-β expression on malignant cells reveal its presence in myelogenous leukemias ...
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Folate-receptor 1 level in periodontal disease: a pilot study
... as folate) is a type of B vitamin which participate in one carbon ...6]. Folate is transported into cells by different trans- port systems: The reduced folate carrier, low-affinity high-capacity ...
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The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment
... In vivo antitumor efficiency of different MTX-loaded mixed micelles was validated in subcutaneous xenograft-bearing mice. As shown in Figure 9 and Table 3, there was no serious body weight loss observed in mice treated ...
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Expression of high affinity folate receptor in breast cancer brain metastasis
... affinity folate receptor (HFR) can be overexpressed in breast cancer and is associated with poor prognosis, however the expression in breast cancer brain metastases (BCBM) is ...
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Stable transfectants of human MCF 7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates
... A major problem in cancer therapy is tumor drug resistance such as is found with antifolates (e.g., methotrexate [MTX]). We are specifically interested in the role of the human folate receptor (hFR) in MTX ...
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A folate receptor beta specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody dependent cell mediated cytotoxicity
... Human folate receptor beta (FRb) fragment including amino acids 22 to 236 (the numbering is based on the sequence in NP001107007 in the National Center for Biotechnology Information database) was cloned ...
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Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes
... Folate receptor alpha (FRA) is a cell surface protein whose aberrant expression in malignant cells has resulted in its pursuit as a therapeutic target and marker for diagnosis of ...
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