forkhead box transcription factor
Activin induction of the ovine follicle-stimulating hormone beta-subunit is mediated by Smad4 and a forkhead box transcription factor
... upon transcription of its unique β-subunit, FSHB, which is carefully regulated by more than six reproductive ...growth factor-β (TGFβ) superfamily (2-5) and GnRH (6), whereas inhibin (6, 7) and follistatin ...
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Forkhead Box Transcription Factor Regulation and Lipid Accumulation by Hepatitis C Virus
... cells (Fig. 2A and C). The Western blot was scanned densitometri- cally using ImageJ software (Fig. 1B and D). Forkhead transcrip- tion factor FoxA2 activates genes involved in hepatic lipid metab- olism ...
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Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo
... pharmacological properties, such as anti-viral, anti-filarial, anti-microbial, anti-fungal and anti-diabetic activities [33–35]. We recently reported that the chloroform frac- tion of C. anthelminticum seeds exhibited ...
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Forkhead box transcription factor FOXO3a suppresses estrogen dependent breast cancer cell proliferation and tumorigenesis
... α and ER-β transactivation activities by FOXO3a in vitro. Tran- sient over-expression of FOXO3a has been shown to lead to increases in ER-α expression and ER-α promoter activity in a reporter assay in ER-α-positive NF639 ...
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Forkhead box transcription factor 1 expression in gastric cancer: FOXM1 is a poor prognostic factor and mediates resistance to docetaxel
... Forkhead box protein M1 (FOXM1), characterised by a 100 amino acid winged-helix DNA binding domain, is a newly unified family member of Forkhead transcription factor ...
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Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
... Another cardinal feature of DCM is lipotoxicity result- ing in part from excessive lipid accumulation [79]. Puthanveetil et al. suggested that FOXO–iNOS–clus- ter domain 36 transporter (CD36) axis was involved in lipid ...
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The Forkhead Transcription Factor Fkh2 Regulates the Cell Division Cycle of Schizosaccharomyces pombe
... the transcription factors responsible for this cell cycle-dependent expression (10, 44, ...binding factor), consisting of Mbp1 and Swi6, and the related SBF (Swi4/Swi6 cell cycle box binding ...
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Genome-wide identification of long noncoding RNAs and their competing endogenous RNA networks involved in the odontogenic differentiation of human dental pulp stem cells
... growth factor receptor; FBN1: Fibrillin 1; FBS: Fetal bovine serum; FISH: Fluorescence in situ hybridization; FoxO: Forkhead box O; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GO: Gene Ontology; ...
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The transcription factor X-box binding protein-1 in neurodegenerative diseases
... transcription factor 6; BACE1: β APP Cleaving Enzyme 1; BiP: Binding immunoglobulin protein; ERAD: Endoplasmic Reticulum Associated protein Degradation; FoxO1: Forkhead box O1; HD: Huntington ...
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The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
... phosphorylate forkhead box protein O1 (FoxO1) in myoblasts, with phosphory- lation blocking nuclear translocation of the transcription factor and inhibiting expression of FoxO1-regulated ...
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The Fox/Forkhead transcription factor family of the hemichordate Saccoglossus kowalevskii
... head box of FoxQ2 proteins from various phyla was used for this analysis, including sequences from the genome of the mollusc Lottia gigantea for which we identified four putative FoxQ2 genes by bidirectional blast ...
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A Forkhead Transcription Factor Is Important for True Hyphal as well as Yeast Morphogenesis in Candida albicans
... two forkhead transcription factors (ScFKH1 and ScFKH2) regulate the expression of B-cyclin ...pombe, forkhead transcription factors also influence ...two transcription factors that ...
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Li, Na (2010): Critical Role of Transcription Cofactor PC4 in Mammals. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... presence of tandem repeats of a heptapeptide sequence at its carboxy-terminus, known as the carboxy-terminal domain (CTD). The CTD has the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser that is highly conserved among ...
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Mosaic analysis of insulin receptor function
... the forkhead transcription factor Foxo1 promotes Pck1, G6pc, and Igfbp1 expression, and is inhib- ited by insulin via Akt-mediated phosphorylation ...G6pc transcription (7), and the observed ...
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miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans
... The first indications of an involvement of the insulin/ IGF-1 pathway in the regulation of lifespan originated from experiments performed on Caenorhabditis elegans, in which mutations reducing the activity of daf-2, an ...
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Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review
... growth factor receptor-positive cells proliferate in response to growth factors and growth factor antagonists are a mainstay of ...growth factor inhibition. Downstream of growth factor ...
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The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1 dependent transcriptional activity
... The forkhead transcription factor FoxO1 has been identified as a negative regulator of insulin/IGF-1 signaling. Its function is inhibited by phosphorylation and nuclear exclusion through a ...
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The role of forkhead genes in eye development and disease
... All previous reports o f 6p25 cytogen etic abnormalities^^ are consistent w ith the co n cep t that altered dose o f a gen e or g en es in th e duplicated or deleted region results in the ocular developm ental ...
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Plant sterols, marine-derived omega-3 fatty acids and other functional ingredients: a new frontier for treating hyperlipidemia
... for transcription factors, enhancing peroxisome proliferator-activated receptor alpha (PPAR- a) activity, while reducting hepatocyte nuclear-4a (HNF-4a) ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... of transcription 3 (Stat3) in these mice was also reduced by 42% as compared with that in control mice (Figure 2F, right panel), suggesting that both insulin and leptin signaling were attenuated in the βHT-IRS2 ...
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