Formyl peptide receptor 3
The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
... To investigate the effect of FPRL1 on NM- as well as SP-induced glial cell activation we incubated primary rat astrocytes and microglia with NM or SP to deter- mine ERK1/2 phosphorylation and changes of cAMP ...
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Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease
... unconventional receptor for the diversity of its agonists and its ability to convey contrasting bio- logical signals, depending on the ligands engaged on ...
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Interleukin-18 Primes the Oxidative Burst of Neutrophils in Response to Formyl-Peptides: Role of Cytochrome b558 Translocation and N-Formyl Peptide Receptor Endocytosis
... fluorescein-conjugated formyl-Nle-Leu-Phe-Nle-Tyr-Lys, primaquine, 2,3-butanedione 2-monoxime (BDM), colchicine, diisopropylfluorophosphate, and a protease inhibitor mix- ture, Sigma Chemical ...
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Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
... acid peptide fragment derived from sequential proteolytic cleavage of the amyloid precursor protein by beta- and gamma-secretases ...protein-coupled receptor, ...
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Exocytosis of Neutrophil Formyl Peptide Receptor-Like 1 (fPRL1) Results in Downregulation of Cytoplasmic fPRL1 in Patients with Purulent Dermatitis
... The upregulation of fPRL1 on neutrophil membranes, regarded as the activation of neutrophils, is induced by preincubation with bacterial LPS and/or cytokines but is hardly induced without this priming condition (1, 6, ...
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The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA
... N-formyl peptide receptors (FPRs) are a family of G-protein-coupled receptors that were initially identified in phagocytic leukocytes, however subsequent reports have demonstrated FPRs to be expressed in ...
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Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells
... Melanoma cells display an inherent ability to switch be- tween modes of migration: a mesenchymal-type movement that requires extracellular proteolysis and an amoeboid movement that requires high Rho-kinase signaling and ...
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Real-time detection of implant-associated neutrophil responses using a formyl peptide receptor-targeting NIR nanoprobe
... Given the ability of the nanoprobe to preferentially target neutrophils associated with particle implants in vivo, it was further investigated whether the nanoprobe could be used to detect inflammatory responses elicited ...
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An angiogenic role for the human peptide antibiotic LL 37/hCAP 18
... active peptide and is referred to as ...The peptide is induced by inflammatory or infectious stimuli and displays direct antimicrobial activity by interaction with the cell membranes of microorganisms ...
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Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
... colitis. 3% (wt/vol) DSS (molecular mass, 36–50 kDa; MP Biomedicals) was dissolved in purified water and orally administered to mice as previously described ...containing 3% DSS from day 0 until day 7, and ...
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Targeting the Formyl Peptide Receptor type 1 to prevent the adhesion of ovarian cancer cells onto mesothelium and subsequent invasion
... built with 37 EOC tissue samples. IHC highlighted vari- able expression of FPR1 both in the cytoplasm and on the plasma membrane of tumor cells (Fig. 7). FPR1 ex- pression levels were evaluated by assessing either the ...
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Characterization of the murine n-formyl peptide chemotactic receptor
... Since murine DNA from FDCP, WEHI-3b and brain DNA gave identical restriction patterns (data not shown), and as it was easier to obtain large amounts of DNA from WEHI-3b, cells these were used. To establish which bands ...
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Cyclic Nucleotide induced Maturation of Human Promyelocytic Leukemia Cells
... morphologically. Formyl-peptide receptor expression was the earliest marker of these modified programs of ...The receptor appeared within 2 h after treatment and increased linearly for 72 ...
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THERANOSTICS: From Molecular Imaging Using Ga-68 Labeled Tracers and PET/CT to Personalized Radionuclide Therapy - The Bad Berka Experience
... The acronym THERANOSTICS epitomizes the inseparability of diagnosis and therapy, the pillars of medicine and takes into account personalized management of disease for a specific patient. Molecular phenotypes of neoplasms ...
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Original Article Correlation of epidermal growth factor receptor (EGFR), androgen receptor (AR) and 14-3-3 sigma expression in breast cancer
... using 100 μl of peroxidase solution for 10 min. The sections were subsequently incubated overnight at 4°C with primary antibodies as fol- lows: EGFR (Maixin, prediluted antibody ready- to-use, RMA-0554, Fuzhou Maixin ...
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Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 23 May 2018 doi:10.20944/preprints201805.0319.v1
... AnxA2 not only impacts fibrinolysis but (in its heterotetrameric form together with S100A10) affects the Toll-like receptor (TLR) signaling. The AnxA2-S100A10 complex activates human and murine macrophages through ...
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Importance of the Vasoactive Intestinal Peptide Receptor in the Stimulation of Cyclic Adenosine 3′,5′ Monophosphate in Gallbladder Epithelial Cells of Man: COMPARISON WITH THE GUINEA PIG
... radioimmunoassay. Specific binding sites for VIP were characterized in these cells. At 37°C, the binding of 125 I-labeled VIP reached a peak within 20 min and then declined rapidly. At 15°C, binding was stable between 90 ...
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Quantifying biased agonism of adenosine and calcitonin like receptors
... in receptor glycosylation, as well as regulating trafficking to the plasma membrane; indeed, CLR can only reach the cell surface in conjunction with RAMPs (McLatchie et al, ...the receptor (Kuwasako et al, ...
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Bis(3 formyl 4 hydroxy 5 methoxyphenyl)methane
... Atom H9, attached to C9, was located in a difference map and refined isotropically [C—H = 0.98 (2) A ˚ ]. The remaining H atoms were positioned geometrically [0.82 (OH), 0.93 (CH) and 0.96 A ˚ (CH 3 )] and ...
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2 Formyl 1 phenylsulfonyl 1H indole 3 carbonitrile
... O3A 0.083 (2) 0.078 (2) 0.103 (3) 0.0102 (19) −0.038 (2) 0.041 (2) S1A 0.0414 (5) 0.0345 (4) 0.0505 (5) 0.0104 (4) 0.0150 (4) 0.0133 (4) C2B 0.0400 (19) 0.058 (2) 0.0424 (19) 0.0186 (17) 0.0088 (15) 0.0112 (16) ...
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