Founder virus
Reappearance of Founder Virus Sequence in Human Immunodeficiency Virus Type 1-Infected Patients
... of founder virus sequences was due to a recombination between V3 and/or p17 regions of founder virus and dominating quasispecies cannot be ...of virus from latently infected cells ...
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Fitness-Balanced Escape Determines Resolution of Dynamic Founder Virus Escape Processes in HIV-1 Infection
... “founder” virus) establishes fulminant infection with expansion throughout the body ...result, founder-specific CTL responses impose selective pressure on the viral population, and consequently, ...
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Genetic Identity and Biological Phenotype of a Transmitted/Founder Virus Representative of Nonpathogenic Simian Immunodeficiency Virus Infection in African Green Monkeys
... One approach to explore viral determinants of in vivo patho- genicity is to generate infectious proviral clones and mutants that differ in virus-specific properties, such as coreceptor tro- pism or accessory gene ...
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The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection
... The number of T/F variants in our study is likely to be underestimated, since only the gp120 V3-V5 sequences were analyzed. Nonetheless, an association between trans- mission of diverse population of SHIV variants, ...
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Initial HIV-1 Antigen-Specific CD8+ T Cells in Acute HIV-1 Infection Inhibit Transmitted/Founder Virus Replication
... CD8-mediated virus inhibition can be detected in HIV-1-positive subjects who naturally control virus ...cell-mediated virus inhibition assay (CD8 VIA) and transmitted/ founder (T/F) ...T/F ...
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Founder virus population related to route of virus transmission: a determinant of intrahost human immunodeficiency virus type 1 evolution?
... Human immunodeficiency virus type 1 (HIV-1) causes a persistent infection in human hosts that ultimately results in AIDS. Extensive genetic variation of HIV-1 is usually observed within infected hosts in the ...
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Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic
... epidemic founder virus sequence (MRCA) and the modern North American subtype B consensus sequence suggests that no polymorphisms present earlier in the epidemic have accumulated to the point where they now ...
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aid.2017.0313.pdf
... the founder virus, likely coming from the same donor (if they were in acute infection) or representing the initial fixation of a few mutations from a single transmission event; given this interpretation, ...
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Autologous Neutralizing Antibodies to the Transmitted/Founder Viruses Emerge Late after Simian Immunodeficiency Virus SIVmac251 Infection of Rhesus Monkeys
... nodeficiency virus, viral evolution, and immune ...the founder virus and mutant viruses in animals PBE (A), CP1W (B), CR2A (C), and CR53 ...autologous founder Envs over ...
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Clonal amplification and maternal infant transmission of nevirapine resistant HIV 1 variants in breast milk following single dose nevirapine prophylaxis
... heterogeneous virus population derived from breast (left and right) milk collected at 4 weeks ...transmitted virus, and its exact genetic ...the virus that established infection in the ...T/F ...
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A Limited Number of Simian Immunodeficiency Virus (SIV) env Variants Are Transmitted to Rhesus Macaques Vaginally Inoculated with SIVmac251
... immunodeficiency virus (SIV) models of mu- cosal HIV transmission are valuable for examining the transmitted or early founder populations that establish produc- tive infection, because the genetic ...
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IKBKB founder mutation). We have previously
... The incidence of Severe Combined Immunodeficiency (SCID) in Manitoba, (1/15,000), is at least three to four times higher than the national average and that reported from other jurisdictions. It is overrepresented in two ...
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Genetic properties of the MAGIC maize population: a new platform for high definition QTL mapping in Zea mays
... S8, Additional files 17 and 18: Figure S10 and S11), and accounting for 13% of the variance in GY. The founder allele effects at the locus show that Mo17 and W153R alleles contribute to low GY values (Fig. 7b, top ...
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Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection
... immunodeficiency virus (HIV) infection, studies of the rate of escape from CD8 ⫹ T cell responses against T/F viruses clearly show that escape can arise as early as a few weeks postinfection at a rate of ...T/F ...
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Founder populations and their uses for breast cancer genetics
... a founder effect. Founder effects occur when a population is established by a small number of people or when a bottleneck occurs that reduces the population to a small ...a founder becomes prevalent ...
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Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling
... In wg mutant embryos, Twist expression is initiated correctly, but high levels of Twist are reduced by mid to late stage 11, the period during which the Slouch clusters appear (Bate and Rushton 1993). We hypothesized ...
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Charles Augustin Coulomb—The Founder of Physiology and Ergonomics
... Because a man can displace along the same path x whether carrying a load or not, since the load is P, we can find the action that he can perform in a day’s work is equal to 3500 − 25.86 [r] ...
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Transmitted/Founder Hepatitis C Viruses Induce Cell Type and Genotype Specific Differences in Innate Signaling within the Liver
... Recent data indicate that HCV genotype 3 is associated with increased rate of fibrosis progression compared to non-3 geno- types (29–31) and, epidemiologically, is an independent risk fac- tor for end-stage liver disease ...
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Phenotypic Characteristics of Mucosally Transmitted HIV-1
... HIV-1, virus is not detected in the circulation for about 10 days, a period termed the eclipse phase (reviewed in ...since virus appears to replicate locally for a period of at least a few days to a week, ...
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Establishment of a Cottontail Rabbit Papillomavirus/HLA-A2.1 Transgenic Rabbit Model
... All founder rabbits showed strong ...the founder rabbits with outbred NZW rabbits and inbred EIII/JC ...these founder lines (Fig. 2A). The offspring from founder lines 2 and 3 showed higher ...
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