Fractalkine/CX3CL1
Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses
... Fractalkine (FKN, CX3CL1) is a membrane-bound CX3C chemokine induced by primary proin- flammatory signals in vascular endothelial cells (ECs). Here we examined the role of FKN in polar- ized Th1 or Th2 ...
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Therapeutic intervention of inflammatory/immune diseases by inhibition of the fractalkine (CX3CL1)-CX3CR1 pathway
... Fractalkine (FKN)/CX3CL1 is a membrane-bound chemokine possessing a chemokine/mucin hybrid structure and a transmembrane domain and has a dual function as an adhesion molecule and a chemoattractant. FKN is ...
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Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient
... Background: Adoptive T-cell based immunotherapies constitute a promising approach to treat cancer, however, a major problem is to obtain effective and long-lasting anti-tumor responses. Lack of response may be due to ...
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The chemokine fractalkine (CX3CL1) attenuates H<inf>2</inf>O<inf>2</inf> induced demyelination in cerebellar slices
... of fractalkine in regulating the oxidative stress response has been ...of fractalkine prior to ischemic insult in wild-type rodents has been shown to produce neuroprotective effects, with smaller infarct ...
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Chorioamnionitis (ChA) modifies CX3CL1 (fractalkine) production by human amniotic epithelial cells (HAEC) under normoxic and hypoxic conditions
... of CX3CL1 in the ...of CX3CL1 using RayBio® Human Fractalkine ELISA Kit has a very high specificity; to the best of our knowledge, it exceeds other available ELISA tests for detection of ...
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Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
... affected fractalkine shedding, the amount of released fractalkine in the conditioned medium of mixed neuron- glial cultures was analyzed by ELISA at 2 h following morphine and/or Tat exposure (Figure ...the ...
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Fractalkine (CX3CL1) enhances hippocampal N-methyl-d-aspartate receptor (NMDAR) function via d-serine and adenosine receptor type A2 (A2AR) activity
... Nevertheless, considering overall data, we can speculate that on microglial cells the activation of CX 3 CR1 triggers the release of adenosine that in turn, via A 2A R activity, increase[r] ...
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Fractalkine (CX3CL1), GM-CSF and VEGF-a levels are reduced by statins in adult patients
... whether CX3CL1, GM-CSF and VEGF-A levels are modulated by LDL cholesterol itself or by in- flammatory cytokines, and how statins may affect CX3CL1, GM-CSF and VEGF-A expression, we incu- bated human ...
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Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity
... with Protein Block (Dako) and an avidin/biotin block- ing kit (Vector, Burlingame, CA, USA). The sections were incubated with 2 μg/ml mouse anti-CX3CL1 mAb (81513; R&D Systems) or 2 μg/ml rabbit anti- CX3CR1 ...
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Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1
... 3). CX3CL1 is relatively abundant in the brain, where sub-populations of neurons constitu- tively express the protein ...of CX3CL1 when compared to cerebral neurons (Table ...astrocytic CX3CL1, ...
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CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin
... • We have provided data to demonstrate constitutive and regulated expression of the chemokine CX 3 CL1 and its receptor CX 3 CR1 by neurons/astrocytes and microglia, respectively, within[r] ...
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CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease
... of CX3CL1 or 90 ng/day of heat-inac- tivated fractalkine (n = 6) (as a control) for 28 days into the site of the lesion (Alzet model 2004: pumping rate ...
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Neuroinflammation and fractalkine signaling in Alzheimer’s disease
... or CX3CL1 105 Δ , was developed and crossed with AD mouse ...PS1; Cx3cl1−/− mouse, Lee et ...APP/PS1; Cx3cl1−/− control ...hTau; Cx3cl1−/− mice, both of which had significantly greater ...
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Original Article The M2 polarization of macrophage induced by fractalkine in the endometriotic milieu enhances invasiveness of endometrial stromal cells
... cytes into the peritoneal cavity of patients with endometriosis [5]. Chemokine FKN is the soli- tary member of a unique CX3C class of chemo- kines that consists of a transmembrane mole- cule with an extracellular region ...
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Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model
... named fractalkine, is the only representative of the CX3C chemokine, being constitutively expressed by neu- ...cause fractalkine to be cleaved from the neuronal ...of fractalkine then interacts with ...
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RETRACTED ARTICLE: Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling
... chemokine CX3CL1 (fractalkine) and its receptor, ...decreased fractalkine/ CX3CR1 signaling in the hippocampus; (ii) inhibition of CX3CR1 function exacerbated the ischemia-induced chronic increase in ...
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<p>Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain</p>
... chemokine CX3CL1 and its microglial receptor CX3CR1 play an important role both in pain initiation and in fl ammatory ...soluble CX3CL1, which acts on CX3CR1 of microglia and resulted in the production of ...
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Involvement of CX3CL1/CX3CR1 axis in etanercept therapy for patients with active rheumatoid arthritis
... Figure 1 changes in serum chemokine levels after eTn administration. Paired serum samples from 18 RA patients with moderate to good responses were collected at baseline and 14 weeks after starting eTn treatment. each ...
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CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration
... transmembraneous CX3CL1 abundantly present in the retina and RPE [34] significantly inhibits the mobility of monocytes expres- sing the CX3CR1-M280 variant ...anchored CX3CL1 in the retina and RPE [34] and ...
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Fractalkine is expressed in the human ovary and increases progesterone biosynthesis in human luteinised granulosa cells
... human fractalkine (R&D Systems, Emeryville, United States) at 100 ng/ml to determine the possible effects of fractalkine on proges- terone and estradiol ...of fractalkine, cells were treated with ...
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