Fructose 1,6-bisphosphatase
Original Article Fructose-1,6-bisphosphatase 1 can be a potential predictive marker for the prognosis of hepatocellular carcinoma patients
... Abstract: Fructose-1,6-bisphosphatase-1 (FBP1), a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic ...
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Case Report Fructose 1,6-bisphosphatase deficiency: clinical manifestations and genetic features in two Chinese patients
... Abstract: Fructose 1,6-bisphosphatase (FBPase) deficiency is a rare disease that is caused by mutations of FBP1 gene. We report our experience with two Chinese patients with FBPase deficiency. Two Chinese ...
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Partial purification and characterisation of cytosolic Fructose-1, 6-bisphosphatase from Drymaria cordata
... enzyme, fructose 1,6-bisphosphatase was carried out following the methods of homogenization, streptomycin sulphate precipitation, ammonium sulphate cut and molecular sieve chromatography through Bio-Gel ...
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Gluconeogenic Fructose 1, 6-bisphosphatase from Ginkgo biloba L.: Isolation and characterization
... the previous step was loaded onto a column (0.6 x 7.0 cm) of BioGel A-0.5m [before this experimentation, the column material was pre-equilibrated with 50 mM Tris-HCl buffer (pH 7.5) containing 0.2 mM ME.] Proteins were ...
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A summary of molecular genetic findings in fructose-1,6-bisphosphatase deficiency with a focus on a common long-range deletion and the role of MLPA analysis
... with fructose-1,6-bisphosphatase deficiency using conventional Sanger sequencing and multiplex ligation-dependent probe amplification analysis, and we provide a mutation update for the fructose ...
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Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
... Figure S1. (a) Metformin inhibition curves of purified mouse FBP1 and rabbit muscle AMPD1 activity. Assays were performed as described in methods and results are expressed as the ratio of the maximum activity in the ...
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Isolation of Degradation-Deficient Mutants Defective in the Targeting of Fructose-1,6-bisphosphatase into the Vacuole for Degradation in Saccharomyces cerevisiae
... This glucose-induced protein degrada- tion occurs primarily in the vacuole, as p q 4 mutants block the induced protein degradation in response to glucose (CHIANC et a[r] ...
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The Gluconeogenic Enzyme Fructose-1,6-Bisphosphatase Is Dispensable for Growth of the Yeast Yarrowia lipolytica in Gluconeogenic Substrates
... If YlFbp participates in the regulation of the expression of YlFBP1, it could be expected that a fraction of it will be found in the yeast nucleus. To test this possibility, we did a subcellular fractionation and ...
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Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity
... STAT3 plays an important role in wound healing and tissue repair in normal tissues [47]. However, excessive activation of STAT3 in malignant tumors results in inflammation-driven repair that promotes drug resistance or ...
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Reduction in sucrose contents by downregulation of fructose-1,6-bisphosphatase 2 causes tiller outgrowth cessation in rice mutants lacking glutamine synthetase1;2
... Rice mutants lacking cFBPase1 presented with severe reductions in growth, tiller number, and sugar (sucrose, glucose, and fructose) levels in the leaf blades (Lee et al. 2008; Koumoto et al. 2013). OscFBP1 was ...
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The intracellular site of synthesis of fructose 1,6 bisphosphatase in rat liver : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University
... The i ncorporatio n o f i sotope by the pre i ncubated wheat germ extract was grea tl y enhanced by the add i tion of TMV RNA . The time course of the reaction s howed l i near i ncorporation for 60 mi nutes and no ...
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Fructose 1,6-bisphosphatase 2-Camk2 interaction is an integral mechanism of long-term potentiation
... plates were filled with 200 μL of buffer or samples and incubated for 10 min prior measurements for system stabilization. Camk2α (3.5 μg/ml) was loaded on the His2 sensor for 120 sec and washed for 60 sec. A reference ...
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Overexpression of 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production
... Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is an important regulatory enzyme of glucose ...of fructose-2,6-bisphosphate, an allosteric activator of the glycolytic enzyme ...
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Enhancement of photosynthetic capacity in Euglena gracilis by expression of cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase leads to increases in biomass and wax ester production
... cycle, fructose-1,6-bisphosphatase and sedoheptulose-1,7-bisphosphatase (FBPase and SBPase, respectively), are potential targets for the optimization of photosynthetic reactions [7, ...cyanobacterial ...
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International practices in the dietary management of fructose 1-6 biphosphatase deficiency
... Fructose 1, 6 bisphosphatase (FBPase) deficiency (OMIM #229700), is a rare, autosomal recessive inherited disorder of gluconeogenesis ...of 6 months following severe metabolic acidosis ...
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Crystal structure of the acyclic form of 1 deoxy 1 [(4 methoxyphenyl)(methyl)amino] D fructose
... of 1-amino-1-deoxy- d -fructose, only those lacking a proton bound to the tertiary amino group can crystallize in the acyclic ...the 1-amino-1-deoxy- d -fructose derivatives ...
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Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
... TIGAR could also play an important role in this com- plexity and participate in shaping the metabolic profile of the cell. It has been demonstrated that TIGAR works as an FBPase-2 and diverts glucose intermediates from ...
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Vol 6, No 1
... 28 th April, 1971, the Pakistani armies launched an operation to capture especially the Hindu families of the teachers of Carmichael College and their family members. Pak-soldiers grabbed six (6) Hindu professors ...
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Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption
... patients, 1 patient with global malab- sorption (patient 9), her 2 parents, and up to 6 healthy con- ...isolated fructose malabsorp- tion defined by a clinical constellation of gas, diarrhea, and ...
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Fructose malabsorption
... the fructose absorbers demonstrated symptoms [24]. With the same fructose dose, 10 % (2/20) of healthy adults demonstrated elevated breath hydrogen without any symptoms ...[13]. Fructose intake is ...
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