fusion genes
Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles
... the fusion genes de- tected in the current study were in-frame and the subtype-defining fusion genes are typically in-frame (ETV6-RUNX1, BCR-ABL1, and KMT2A rearrange- ments; TCF3-PBX1, ...
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Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.
... recurrent fusion gene(s) or mutations in 273 genes recurrently mutated in breast ...family genes and ...high-confidence fusion genes, eight of which were validated and two of which were ...
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Optical coding of fusion genes using multicolor quantum dots for prostate cancer diagnosis
... of 1 fmol. Here we showed simultaneous detection of multiple TMPRSS2–ERG fusion genes using color-coded oligonucleotides in a single assay. The assay required 60 minutes incubation to selectively and ...
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SOX2 expression is associated with <em>FGFR</em> fusion genes and predicts favorable outcome in lung squamous cell carcinomas
... Materials and methods: SOX2 protein levels were measured by immunohistochemistry, while SOX2 copy numbers were measured by fluorescence in situ hybridization in resected samples from 162 Chinese lung SCC patients. All ...
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Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer.
... of fusion events in metastatic disease, when compared to primary ER-positive cancer; this suggests that fusion genes might, in themselves, be a biomarker of advanced and aggressive ...the ...
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Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
... of fusion genes or aberrant fusion transcript expression, we performed RNA sequencing of EC cell lines and their non- malignant ES cell line ...novel fusion transcripts and one gene with ...
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Recurrent MET fusion genes represent a drug target in pediatric glioblastoma.
... 1 Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg,.. 24.[r] ...
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The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma
... first fusion gene found in glioblastoma was the re- arrangement located at an amplified region at chromosome 4q12, resulting in the fusing of the kinase domain of PDGFRA with the regulatory domains of KDR (VEGFR2) ...
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Identification and Characterization of Genes Required for Cell-to-Cell Fusion in Neurospora crassa
... fusion proteins. The transcription factor PP-1 is a target for phosphor- ylation by MAK-2. PP-1, along with the other transcription factors identified (ADV-1, ADA-3, SNF5, and the dimeric RCO-1/RCM-1), is proposed ...
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Advances in Fusion Gene Research and Fusion Gene Families in Hematological Malignancies
... Fusion genes (FGs) are major molecular biological abnormalities in hematological malignancies and have become well-established molecular markers for disease classification, risk stratification, and targeted ...
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Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma
... larger cohort of PMAs cases is required to determine if such association exist. Three samples (8.8%) had both 15–9 and 16–9 fusion genes identified in the same tumor. These samples were tested at least ...
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Original Article ROS1 gene rearrangement and clinicopathological characteristics in Chinese NSCLC patients
... Abstract: Objective: Since Rikova et al. reported c-ros oncogene 1 (ROS1) rearrangements in non-small cell lung cancer (NSCLC) in 2007, data on the clinicopathological characteristics of ROS1-positive patients in China ...
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Import-Associated Translational Inhibition: Novel In Vivo Evidence for Cotranslational Protein Import into Dictyostelium discoideum Mitochondria
... aequorin fusion genes by spliced overlap extension ...final fusion gene. A GFP fusion with the first 82 amino acids of Dictyostelium mitochondrial DNA topoisomerase II (topA) was constructed ...
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New stable anchor protein and peptide linker suitable for successful spore surface display in B. subtilis
... major part of UreA (amino acid residues 148 to 717). However, surface display was very inefficient [10]. A pos- sible explanation was the burying of UreA in the spore coat due to its direct linking to CotB and we ...
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Cloning of fimH and fliC and expression of the fusion protein FimH/FliC from Uropathogenic Escherichia coli (UPEC) isolated in Iran.
... The genes that contain significant numbers of rare codons are more likely to completely fail to express or express at low levels (19, ...their fusion genes in Web site of http:// ...their ...
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Concurrent acute myeloid leukemia and T lymphoblastic lymphoma in a patient with rearranged PDGFRB genes
... In 2008, a new class of hematopoietic system disorders, myeloid and lymphoid neoplasms with eosinophilia and abnormalities in PDGFRA, PDGFRB and FGFR1 genes, was created by WHO [1]. Although most cases presented ...
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Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14)
... in fusion of HMGA2 with the C9orf92 gene (from ...HMGA2-C9orf92 fusion transcript would code for a putative protein containing amino acid residues 1 – 94 of HMGA2 and 6 amino acid residues from the ...
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De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance
... 79 fusion-protein transcripts in the cancer samples, we estimated the fold-change in gene expres- sion of the 3′ partner genes involved in the fusion rela- tive to their expression in their normal ...
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Analysis of the cell fusion activities of chimeric simian immunodeficiency virus-murine leukemia virus envelope proteins: inhibitory effects of the R peptide.
... the fusion activity of viral envelope proteins, we expressed simian immunodeficiency virus (SIV)-MuLV chimeric proteins in which the entire cytoplasmic tail of the SIV envelope protein was replaced by either the ...
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Molecular characterisation of PHA synthase and the in vivo synthesis of functionalised PHA beads with surface immobilised proteins : a thesis presented in partial fulfilment of the requirements of the degree of Master of Science in Microbiology at Massey University, Palmerston North, New Zealand
... recombinant genes, resulting in the overproduction of ...produce fusion proteins which have an N-terminal polyhistidine-tag fused to the N-terminus of an IgG binding ZZ domain of protein A from ...
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