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FXIII-A

(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors

(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors

... for FXIII-A inhibition involving attack by C314 at the 2-position (bearing the primary carboxamide) on the epoxide ring of ...to FXIII-A in the initial complex via formation of an additional H-bond from ...

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Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis

Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis

... between FXIII-A V34L and cardiovascular disease. The relationship between FXIII-A V34L and MI has been summarised in a meta-analysis of 28 studies 10 , indicating that V34L is associated with a small but ...

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Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism

Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism

... of FXIII Val34Leu polymor- phism in the RM and RIF cases when compared with the control ...of FXIII is the mechanical stabilization of fibrin clot and the protection of newly formed fi- brin from the prompt ...

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Recombinant factor XIII and congenital factor XIII deficiency: an update from human and animal studies

Recombinant factor XIII and congenital factor XIII deficiency: an update from human and animal studies

... of FXIII is present in monocytes/macrophages and platelets as a homodimer of two A ...thrombin, FXIII becomes plasma transglutaminase, which crosslinks γ-glutamyl-ε-lysine residues of fibrin chains and ...

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Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A

... kinase 3-cre.Flox mice underwent efficient recombination and reduced plasma FXIII-A to 34% (Figure IV in the online-only Data Supplement). Assuming that this result is representative, it would imply that a ...

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Phenotype and genotype of FXIII deficiency in two unrelated probands: identification of a novel F13A1 large deletion mediated by complex rearrangement

Phenotype and genotype of FXIII deficiency in two unrelated probands: identification of a novel F13A1 large deletion mediated by complex rearrangement

... Hereditary FXIII deficiency (FXIIID) is a rare bleeding disorder with a prevalence of one per two million indi- ...II FXIII- A deficiency (FXIIID-A) and FXIII-B deficiency (FXIIID- ...of ...

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PubMedCentral-PMC5680043.pdf

PubMedCentral-PMC5680043.pdf

... of FXIII activation kinetics on whole blood clot composition (RBC retention) 12,39 , what is the effect of the Val34Leu polymorphism in more physiologically- relevant whole blood systems? Studies have shown that ...

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Factor XIII activity mediates red blood cell retention in venous thrombi

Factor XIII activity mediates red blood cell retention in venous thrombi

... abolish, FXIII activation and fibrin crosslinking. The ob- served delay in FXIII activation and fibrin crosslinking was tempo- rally associated with the timing of clot retraction (60–90 ...formation, ...

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Correlation of FXIII Val34Leu Polymorphism with Decreased Risk of Myocardial Infarction in Egypt

Correlation of FXIII Val34Leu Polymorphism with Decreased Risk of Myocardial Infarction in Egypt

... The FXIII gene has several common single nucleotide sequence variations, which encode amino acid ...the FXIII-A subunit is located on chromosome 6p24–25, spanning 160 kilobases (kb) and consists of 15 exons ...

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Factor XIII Val 34 Leu polymorphism and migraine

Factor XIII Val 34 Leu polymorphism and migraine

... Activated FXIII catalysed the forma- tion of covalent ã-glutamyl-å-lysine bonds between fibrin monomers, and is involved in the formation of these bonds between other proteins, such as fibronectin and ...of ...

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Thesis

Thesis

... delayed FXIII activation relative to ...facilitate FXIII binding in ...for FXIII compared to wild-type fibrinogen and a corresponding 5-fold decrease in FXIII activation ...to ...

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The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit

The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit

... Fibrinolysis rates of fibrin clots formed in the presence of full-length or truncated recombinant FXIII-A were mea- sured by the use of non-fluorescence confocal microscopy as previously described [32]. Clots were ...

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The interaction between fibrinogen and zymogen FXIII-A₂B₂ is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits

The interaction between fibrinogen and zymogen FXIII-A₂B₂ is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits

... anti-human FXIII-A [1:1000], or rabbit anti- human FXIII-B [HPA003827, 1:500]) overnight at 4°C before incubation with fluorescently- labeled secondary antibodies for 1 hour at room ...of FXIII-A or ...

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The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit

The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit

... length FXIII-A, consistent with the results shown here for the recombinant ...truncated FXIII could no longer promote effective binding and alignment of the reactive Q and K substrates ...the FXIII-A ...

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Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis

Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis

... in FXIII activity once it has been fully activated, as Wartiovaara et ...between FXIII-A WT and V34L 16 . We also exclude differences in FXIII-A concentrations as identical amounts of protein were ...

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Factor XIII deficiency: a review of literature

Factor XIII deficiency: a review of literature

... Congenital FXIII deficiency is a rare bleeding disorder, with an autosomal recessive trait inheritance, and a frequency of about 1 in 2 million ...of FXIII deficiency are associated with FXIII-A ...

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Catridecacog: a breakthrough in the treatment of congenital factor XIII A-subunit deficiency?

Catridecacog: a breakthrough in the treatment of congenital factor XIII A-subunit deficiency?

... Congenital FXIII deficiency is a rare autosomal-recessive trait that mostly results from an FXIII A-subunit ...to FXIII; therefore, specific FXIII assays are necessary to detect the ...

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Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective

Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective

... out FXIII-AP becomes dissociated in less time (30 ns) at a constant separation force than the dimer with the intact activation peptides (60 ns) ...of FXIII-AP also results in a weaker interaction between ...

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Britains mean streets

Britains mean streets

... ("Culturally, Britain just doesn't like children much," says Batmanghelidjh.) In Victorian England, rich children were banished to nurseries and boarding schools, while their p[r] ...

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Persuasivewriting.ppt

Persuasivewriting.ppt

... Developing the argument Comparison and Contrast Statistics and Authoritative Opinion Similarities and differences between points, positions Use eg, anecdotes. Sources – relevant,[r] ...

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