G-quadruplex
Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo
... The crystal structure of the parallel-type 18-mer c-myc G-quadruplex (Pu18, built by Tian–Miao Ou, et al.) [30] was used as the initial model for investigating the interaction between QPB-15e and c-myc DNA. ...
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Chiral metallohelices enantioselectively target hybrid human telomeric G quadruplex DNA
... The design and synthesis of metal complexes that can specifically target DNA secondary structure has attracted considerable attention. Chiral metallo- supramolecular complexes (e.g. helicates) in partic- ular display ...
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Mirror image dependence : targeting enantiomeric G quadruplex DNA using triplex metallohelices
... taken G-quadruplex (G4) DNA as an example which has diverse conformations and distinct biofunctions, 10 pairs of iron triplex metallohelices binding to D- and L-G4 DNA have been ...
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RHPS4 G quadruplex ligand induces anti proliferative effects in brain tumor cells
... telomere G-quadruplex and inhibition of the c-Myb proto-oncogene ...of G-rich elements at the c-Myc ...the G-rich region upstream of the P1 promoter of the c-Myc gene controls ,90% of its ...
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Qualitative SERS analysis of G-quadruplex DNAs using selective stabilising ligands
... of G-quadruplex ...of G-quadruplexes that is based on the unique SERS response given by three G-quadruplex stabilising ...of G-quadruplex DNAs, the ligand binds strongly ...
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Telomere damage induced by the G quadruplex ligand RHPS4 has an antitumor effect
... The G-rich strand of telomeric DNA can fold into a 4-stranded structure known as the G-quadruplex (G4), whose stabilization alters telomere function limiting cancer cell ...
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Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment
... by G-quadruplex compounds (A) HeLa cells were transfected with either Cherry-EBNA1 (aa 1\ to 440) (denoted as Cherry-EBNA1 ⌬ ) or Cherry vector alone, sorted for red fluorescent protein (RFP) signal, ...
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QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs
... where G-quadruplexes may be formed, rather than specific ...proximate G-quadruplexes, are called regions with ‘G4 potential, ’ or G4P ...of G-tracts, the higher predicted stability [54], or other ...
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Modelling the regulation of telomere length: the effects of telomerase and G quadruplex stabilising drugs
... called G-quadruplexes (G4), discovered by Henderson et ...When G-quadruplexes are located at the very end of the telomeric G-overhang, which has been shown to be their preferred location (Tang et ...
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Supramolecular assembly and metal coordination in G quadruplex structures : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University, Manawatu, New Zealand
... 3+1 G-quadruplex based on the 3htel sequence have highlighted the significance of the Watson-Crick base pair formed in this ...the G-quadruplex is completely destabilised, however, evidence ...
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Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells
... forms quadruplex structure it cannot be elongated by telomerase ...telomeric G-quadruplex are considered as promising anticancer agents [17, 18], the first example was reported by Sun et ...potent ...
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Electrochemical and Spectroscopic Study on the Interaction Between G-Quadruplex DNA and (R)-/(S)-2-(5-Fluorouracil-1-Acetyl) Amido-1, 5-Dimethyl Glutarate
... The cyclic voltammetry and ultraviolet-visible absorption spectrometry have proved to be powerful electrochemical means for the research of interactions between G-quadruplex DNA (G4-DNA) and chemical ...
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CNBP Homologues Gis2 and Znf9 Interact with a Putative G-Quadruplex-Forming 3′ Untranslated Region, Altering Polysome Association and Stress Tolerance in Cryptococcus neoformans
... Gis2 and Znf9 regulate resistance to stress. Human CNBP/Znf9 has been impli- cated in the regulation of translation, and the S. cerevisiae Gis2p interacts with the ribosome and is shuttled to stress granules under ...
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← Return to Article Details INDUCTION OF C-MYC G-QUADRUPLEX DNA AND CYTOTOXICITY OF A CALIX[4]ARENE-CONTAINING BINUCLEAR RUTHENIUM(II) COMPLEX
... c-myc G-quadruplex has been firstly investigated by the electronic spectra, as shown in ...[c-myc G-quadruplex DNA] ...c-myc G- quadruplex ...
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Development of g-quadruplex stabilizers as anticancer drug therapy and selective agonists of the human oxytocin receptor as a therapeutic tool for neuropsychiatric disorders
... a G-quadruplex formation assay can accurately identify G-quadruplex binding compounds that inhibit ...selective G- quadruplex stabilizers of the human telomeric ...of ...
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The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage
... Pfh1? s role at a different class of hard to replicate sites, stable non-canonical DNA secondary structures such as the G-quadruplex (G4), has not been systematically ex- plored. G4 structures are stable ...
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“Synthesis of New Poly Amide linked Heterocyclesas G-quadruplex Stabilizing Agents” by Kawkab Saour, Dunya Lafta, Iraq.
... In this study, we report novel compounds as polyamide compounds with aliphatic tertiary amine tail, compounds synthesized by conventional solution method employing DIC/HOBT as coupling system. The building block molecule ...
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Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models
... of G-quadruplex (G4) structures in promoters is a novel promising strategy to regulate gene expression at transcriptional and translational ...Two G-rich sequences able to fold into G4, have been ...
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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
... Consequently, the ability of the new-generated G- quadruplex ligands 2 and 3 to cause telomere uncapping has been investigated. To this aim, a two-steps analysis was performed to establish, in a first case, ...
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Does G-quadruplex DNA have a functional role in regulation of the transcriptome?
... in G-Quadruplex has been ...of G- quadruplex formation at the well characterised CT element in the c-MYC ...of G-quadruplex I designed a gene editing strategy to reengineer the ...
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