G1/S transition
PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma
... between PRMT5 and CDK4, we predicted that PRMT5 impacts HCC cell proliferation via the effect of binding with CDK4. CDK4 is well known as an oncogene and a significant clinical marker in HCC progression [37]. Moreover, ...
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Overexpression of DOC-1R Inhibits Cell Cycle G1/S Transition by Repressing CDK2 Expression and Activation
... kinase substrate that controls the microtubule organ- ization of metaphase II mouse oocytes. A previous study reinforced the importance of this gene pathway in controlling spindle stability during metaphase II arrest ...
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MicroRNA 503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma
... the G1/S transition, miRNA target pre- diction databases, such as TargetScan, miRanda, and PicTar, were employed to predict miR-503 ...the G1/S transition among the predicted ...
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Analysis of cyclin CDK mediated regulation of the G1/S transition in post quiescent murine fibroblasts
... in G1 cells accelerated their S-phase entry, indicating that cyclin A is rate limiting for the G1-to-S (G1/S) transition (Resnitzky et ...
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Human cytomegalovirus infection inhibits G1/S transition.
... How can these findings be reconciled with earlier experi- ments showing that CMV stimulates cell DNA synthesis? Many of the earlier studies were carried out with lower virus inocula that failed to successfully initiate ...
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MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes
... BrdU elisa assay was performed by use of a Cell prolifer- ation Brdu Elisa Assay kit (Roche, 11647229001). CNE cells transfected with indicated small RNAs were syn- chronized at G1 phase by hydroxyurea treatment. ...
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White Spot Syndrome Virus IE1 and WSV056 Modulate the G1/S Transition by Binding to the Host Retinoblastoma Protein
... raised. One possible explanation is that manipulation of the Rb- E2F pathway is essential to WSSV replication and that the virus adopts a redundancy strategy to guarantee the repression of the Rb protein(s). ...
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Genetic Analysis of the Shared Role of CLN3 and BCK2 at the G1-S Transition in Saccharomyces cerevisiae
... regulating transcription at START: (1) Cln3 induces transcrip- Johnston, L. H., and N. F. Lowndes, 1992 Cell cycle control of DNA tion of SBF/MBF target genes by activating SBF and MBF; (2) synthesis in budding yeast. ...
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Regulation of the G1-S transition by cyclin-dependent kinase inhibitors
... The Ink4 family of proteins consists of four members, p16 Ink4a (63, 71, 89), p15 Ink4b (27, 63), p18 Ink4c (22, 29), and p19 Ink4d (23, 29), and all are specific inhibitors of cdk4/6-cyclin D complexes. Both p16 Ink4a ...
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Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification
... As the cell cycle progression is elaborately regulated by the cyclin-dependent kinases (CDKs), to investigate whether MA2 affect CDK expression, we searched the online database of RNA methylation (http://rna.sysu. ...
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A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells.
... the G1/S transition, mediate this decision by integrating DNA damage and mitogen ...facilitate G1 progression downstream of serum ...where G1 cells that have passed the RP can revert to ...
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Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1
... the G1/S transition, CIP2A knockdown may impede the G1/S progression by downregulating these proteins via E2F1 in E7-expressing ...
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PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis
... of G1/S transition, and inhibition of cell proliferation ...of G1/S transition, and acceleration of hepatoma cell proliferation ...the G1/ S transition and ...
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YAP promotes neural crest emigration through interactions with BMP and Wnt activities
... function in premigratory NC cells demonstrate that YAP activity is both necessary and sufficient to drive EMT of trunk level NC progenitors. This is associated with the regulation of G1/S transition, ...
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CAV3.1 knockdown suppresses cell proliferation, migration and invasion of prostate cancer cells by inhibiting AKT
... the G1/S transition, demonstrated by significantly increased G1 proportion and significantly decreased S proportion (Figure 2F), was observed in PC-3 and DU145 cells with ...promoting ...
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<p>Differentiation antagonizing non-protein coding RNA modulates the proliferation, migration, and angiogenesis of glioma cells by targeting the miR-216a/LGR5 axis and the PI3K/AKT signaling pathway</p>
... Additionally, we investigated the effects of miR-216a sup- pression on growth and metastasis in si-DANCR-2-trans- fected glioma cells. First, we found that miR-216a expression was signi fi cantly inhibited by transfection ...
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The ubiquitin-proteasome system in glioma cell cycle control
... The earliest evidence indicative of an association be- tween the stability of cell cycle proteins and UPS in gli- omas concerns the cyclin-dependent kinase inhibitor p27, which was proved to be degraded in a proteasome- ...
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Pkc1 Acts Through Zds1 and Gic1 to Suppress Growth and Cell Polarity Defects of a Yeast eIF5A Mutant
... eIF5A is highly conserved throughout evolution, from archeabacteria to mammals, and this may reflect at some level a conservation of function. Therefore, as budding is not a mechanism ubiquitously used for eukaryotes to ...
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Upregulation of the Non-Coding RNA OTUB1-isoform 2 Contributes to Gastric Cancer Cell Proliferation and Invasion and Predicts Poor Gastric Cancer Prognosis
... Ectopic overexpression of OTUB1-isoform 2 in gastric cancer cells stimulated proliferation by inducing G1-S transition, suppression of cell apoptosis and promotion of tumor cell invasi[r] ...
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Original Article Effects of allicin on the proliferation and cell cycle of chondrocytes
... using flow cytometry showed that allicin treat- ment induced a marked reduction in the G0/G1 ratio in the cell cycle and the proportion of S ratio was increased. These findings suggest that allicin ...
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