Gastric Carcinogenesis
The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis
... were increased in NUGC-3 as well as AZ521 cells scarcely expressing miR-23b and SC-M1 cells expressing miR-23b after infection with miR-23b-expressing adenoviruses as compared with those infected with green fluorescent ...
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H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis
... of gastric car- cinogenesis, especially in intestinal-type gastric ...developing gastric cancer than those without ...of gastric can- cer development, the role of mtMSI in gastric ...
8
Original Article Myenteric denervation in gastric carcinogenesis: differential modulation of nitric oxide and annexin-A1
... Initially, to confirm the protective effect of endogenous NO on tumor development, ani- mals were treated with MNNG and AG, a NOS inhibitor, for 20 weeks. AG increased the num- ber of animals with adenocarcinomas, ...
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Original Article Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis
... in gastric mucosa during gastric ...Methods: Gastric biopsy specimens were taken from 148 patients and divided into five groups, including normal group (n = 10), chronic superficial gastritis group ...
6
let 7b/g silencing activates AKT signaling to promote gastric carcinogenesis
... in gastric cancer and its knockdown suppressed gastric cancer cell proliferation, reduced monolayer colony formation and inhibited xenograft formation in vivo, resembling the tumor-suppressive effects of ...
12
Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma
... The current study also suggested that YY1 affected Wnt signaling cascades in gastric cancer cells. By using Cancer 10-pathway Reporter Luciferase Assay, we iden- tified that siYY1 inhibited Wnt/β-catenin signaling ...
11
p53, a potential predictor of Helicobacter pylori infection- associated gastric carcinogenesis?
... primary gastric adenocarcinoma with ...of gastric mucosa atrophy ...the gastric carcinogenesis of ...in gastric tumours with CagA-positive ...that gastric epithelial cells ...
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Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend
... Background: Two of the Wnt signaling pathway target genes, tumor necrosis factor receptor family member (TROY) and leucine-rich G-protein coupled receptor (LGR5), are involved in the generation and maintenance of ...
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Original Article Comparative transcriptome analysis using RNA-Seq screening reveals critical genes and regulatory mechanisms of gastric carcinogenesis involved in helicobacter pylori infections and CagA
... synergizing with EGFR can promote epithelial cancer development [27]. In the current study, EGFR and VEGFA were upregulated after H. pylori infections, indicating EGFR and VEGFA might play a critical role in H. pylori ...
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The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas
... of gastric adenomas may illustrate the temporal order of key somatic mutations in early gastric ...of gastric carcinogenesis before clonal sweeps, and that key initiating events such as APC ...
10
Toll Like Receptors as Biomarkers of Gastric Carcinogenesis: Implications for Diagnosis, Prognosis and Treatment
... that gastric Hp infection increases TLR expression in the gastric ...human gastric carcinogenesis is associated not only with increased expression of TLR but also with de- creased expression ...
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JMJD2B is required for Helicobacter pylori -induced gastric carcinogenesis via regulating COX-2 expression
... human gastric tissues from gastritis to gastric ...and gastric cancer ...of gastric carcinogenesis and it may serve as a novel target for the intervention of gastric ...
12
Profiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis
... EBV-associated gastric carcinoma, and in silico analysis revealed that the target genes of these EBV miRNAs had functions associated with cancer-related pathways, especially the regulation of ...EBV-associated ...
11
Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis
... both metabolic profiles and metabolite levels associated with gastric carcinogenesis. It is also used to exploit the early diagnostic approach for GC [5-7]. Miyagi et al. analyzed markedly altered ...
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Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation
... test, the difference between the two groups is statistically signifi- cant (P ⬍ 0.01). We found that all 6 cancer strains and 4 of the non-cancer strains are CagA positive. Two of the non-cancer strains (T135 and T151) ...
9
Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
... in gastric cancer development? Which virulent factor of ...in gastric cancer, need to be further ...of gastric cancer, but it can not completely prevent ...
10
Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype
... In this study, intramucosal differentiated-type cancers were sub-classified into 3 groups according to the tumor nuclear grade: low, intermediate or high. The tumor grade was determined according to previously published ...
9
<p>Evaluation of C5orf66-AS1 as a Potential Biomarker for Predicting Early Gastric Cancer and Its Role in Gastric Carcinogenesis</p>
... Our study has two main limitations. First, we included both EGC and AGC patients for comprehensively diagnostic ef fi cacy analysis. However, EGC cases were still limited, and AGC cases were not evaluated as Phase II and ...
11
QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis
... Alternative pre-mRNA splicing is a key mechanism for increasing proteomic diversity and modulating gene expression. Emerging evidence indicated that the splicing program is frequently dysregulated during tumorigenesis. ...
14
The roles of BTG3 expression in gastric cancer: a potential marker for carcinogenesis and a target molecule for gene therapy
... BTG (B-cell translocation gene) can inhibit cell proliferation, metastasis and angiogenesis, cell cycle progression, and induce differentiation in various cells. Here, we found that BTG3 overexpression inhibited ...
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