GASTRIN-RELEASING PEPTIDE
Gastrin releasing peptide in human nasal mucosa
... Gastrin-releasing peptide GRP, the 27 amino acid mammalian form of bombesin, was studied in human inferior turbinate nasal mucosa.. GRP-immunoreactive nerves detected by the immunogold m[r] ...
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Transcriptional activation and DNase I hypersensitive sites are associated with selective expression of the gastrin releasing peptide gene
... The gastrin-releasing peptide (GRP) is a neuropeptide hormone and growth factor produced normally by neural and neuroendocrine cells, as well as by human small-cell lung cancer (SCLC) tumors and ...
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Specific Antibodies Elicited by a Novel DNA Vaccine Targeting Gastrin-Releasing Peptide Inhibit Murine Melanoma Growth In Vivo
... of gastrin-releasing peptide (GRP) in various types of cancer, especially in malignant melanoma of the skin, suggest that GRP might be a putative target for immunotherapy in neoplastic ...
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Transient elevation of messenger RNA encoding gastrin releasing peptide, a putative pulmonary growth factor in human fetal lung
... Gastrin-releasing peptide (GRP), the mammalian homologue of the amphibian peptide bombesin, is present in pulmonary neuroendocrine cells and appears to be a growth factor for both normal and ...
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A rhesus monkey model to characterize the role of gastrin releasing peptide (GRP) in lung development Evidence for stimulation of airway growth
... Gastrin-releasing peptide (GRP) is developmentally expressed in human fetal lung and is a growth factor for normal and neoplastic lung but its role in normal lung development has yet to be clearly ...
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Spinal cord interneurons expressing the gastrin releasing peptide receptor convey itch through VGLUT2 mediated signaling
... the gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of ...agonist gastrin-releasing peptide induced spike responses in ...itch-inducing ...
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In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies
... PCa. Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overex- pressing ...
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Constitutive activation of the gastrin releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460
... Gastrin-releasing peptide (GRP) causes multiple effects in humans by activating a specific heptaspanning receptor. Within the gastrointestinal tract, GRP receptors (GRP-R) are not normally expressed ...
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Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer
... Abstract: Bombesin (BBN), an analog of gastrin-releasing peptide (GRP), specifically binds to GRP receptors, which are overexpressed in human prostate cancer (PC). Here, we synthesized a BBN-modified ...
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<p>Paclitaxel-loaded nanobubble targeted to pro-gastrin-releasing peptide inhibits the growth of small cell lung cancer</p>
... Small cell lung cancer (SCLC) is a recalcitrant malignancy, which constitutes approximately 14% of all lung cancers. 1,2 Unlike non-small cell lung cancer (NSCLC), SCLC possesses the propensity for early metastases, and ...
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Review Article Meta-analysis of serum gastrin-releasing peptide precursor as a biomarker for prognostic evaluation of small cell lung cancer
... Abstract: Background and aims: The clinical value of gastrin-releasing peptide precursor (Pro-GRP) in small cell lung cancer (SCLC) remains controversial. This meta-analysis aimed to investigate the ...
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First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9
... The amphibian skin is a quasi-unlimited source of biologically active peptides, which have been the ob- ject of extensive pharmacological studies in the past decades [1]. Most of these peptides have their coun- terparts ...
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Original Article Establishing reference intervals of gastrin-releasing peptide precursor by analysis of laboratory-stored data
... Abstract: Objective: To establish and verify the feasibility of reference intervals (RIs) of gastrin-releasing peptide pre- cursor (ProGRP) by analysis of laboratory-stored data. Methods: The ...
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Levels of gastrin releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis
... (bombesin/gastrin-releasing peptide (BN/GRP), substance P (SP), vasoactive intestinal peptide, calcitonin-gene-related peptide, and neuropeptide Y) and the three cytokines tumour ...
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Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors
... beled gastrin-releasing peptide receptor (GRP-R) ligands for detecting metastatic disease and monitoring disease progression [3, ...oping peptide receptor radionuclide therapy (PRRT) ...
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Perinatal testosterone exposure is critical for the development of the male-specific sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that mediates erection and ejaculation
... Gastrin-releasing peptide (GRP), a brain-gut peptide, is expressed and distributed widely in the central ner- vous system as well as in the gastrointestinal tract of mammals ...
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Pro-gastrin-releasing peptide (ProGRP) as a biomarker in small-cell lung cancer diagnosis, monitoring and evaluation of treatment response
... of small-cell cancer cells is their neuroendocrine (NE) phenotype, associated with possessing the properties of the amine precursors uptake and decarboxylation (APUD) system. Small-cell cancer cells are characterized by ...
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Gastrin-releasing Peptide Receptor Imaging in Breast Cancer Using the Receptor Antagonist 68Ga-RM2 And PET
... The gastrin-releasing peptide receptor (GRPR) is a promising target for molecular imaging and targeted therapy, showing an overexpression in several human tumors such as prostate carcinoma, breast ...
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Gastrin-Releasing Peptide Receptor Antagonism Induces Protection from Lethal Sepsis: Involvement of Toll-like Receptor 4 Signaling
... In sepsis, toll-like receptor (TLR)-4 modulates the migration of neutrophils to infectious foci, favoring bacteremia and mortality. In ex- perimental sepsis, organ dysfunction and cytokines released by activated ...
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Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study
... Although in the current study we also found no asso- ciation between GRPR expression and pack-years of smoking, we did observe associations between smoking status (active versus former smoker versus never smo- ker) and ...
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