Gastroretentive Dosage
Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate
... Abstract: In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDF ...
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GASTRORETENTIVE DOSAGE FORMS: REVIEW ON FLOATING DRUG DELIVERY SYSTEMS
... various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug ...various gastroretentive approaches designed ...
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Formulation and evaluation of clarithromycin gastroretentive dosage form
... Clarithromycin is a macrolide antibiotic widely recommended in H.pylori mediated peptic ulcers, Upper Respiratory Tract Infections (1).The prescribed adult oral dosage of clarithromycin is 500 mg twice daily for ...
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Formulation and In Vitro Evaluation of Gastroretentive Dosage Form of Gabapentin.
... Preformulation may be described as a phase of the research and development process where the formulation scientist characterizes the physical, chemical and mechanical properties of new drug substances, in order to ...
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GASTRORETENTIVE DRUG DELIVERY TECHNOLOGIES: REVIEW
... [1] Gastroretentive dosage forms are designed to be retained in the gastric region for prolonged time and release incorporated drug candidates and thereby enable sustained and prolonged input of the drug to ...
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Floating Drug Delivery System
... (CR) dosage forms have been extensively used to improve therapy with several important ...release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would ...
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REVIEW ON GASTRORETENTIVE MUCOADHESIVE MICROSPHERE
... times. Gastroretentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of ...for Gastroretentive dosage ...
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GASTRORETENTIVE SUPERPOROUS HYDROGEL TABLETS OF DEXLANSOPRAZOLE
... release dosage forms. The aim of this study was to prepare Gastroretentive dosage form based on SPH using Dexlansoprazole, a proton pump inhibitor as a model drug for swelling & prolonged drug ...
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A REVIEW ON FLOATING TYPE GASTRORETENTIVE DRUG DELIVERY SYSTEM
... effects. Gastroretentive dosage forms can remain in the gastric region for long periods and hence significantly prolong the gastric retention time (GRT) of ...several gastroretentive drug delivery ...
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“GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN EMERGING APPROACH TO IMPROVE THE GASTRIC RESIDENCE TIME OF SOLID DOSAGE FORMS” by Manmohan*, Shukla T P, Mathur A, Upadhyay N, Sharma S, India.
... These gastroretentive drug forms are easily swallowed and reach a significantly larger size in the stomach due to swelling or unfolding processes that prolong their gastroretention time (Figure ...the ...
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DEVELOPMENT AND EVALUATION OF METOPROLOL SUCCINATE LOADED SUPERPOROUS HYDROGEL IN A CAPSULE: AS A GASTRORETENTIVE DRUG DELIVERY DEVICE
... Metoprolol succinate (MS) is a b1-selective adrenergic blocking agent. [7] Since the half-life of MS is ~3 to 4 h [9] multiple doses are needed to maintain a constant plasma concentration for a good therapeutic response ...
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“GASTRORETENTIVE DRUG DELIVERY SYSTEMS: NOVEL APPROACHES AND ITS EVALUATION - A REVIEW” by M V Srikanth*, B Janaki Ram, S A Sunil, N Sreenivasa Rao, and K V Ramana Murthy, India.
... of dosage forms, which are being administered through different ...the gastroretentive drug delivery systems (GRDDS) such as role and properties of gastrointestinal (GI) tract, factors affecting the gastric ...
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INVESTIGATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM
... window. Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic ...effects. ...
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“Formulation and Evaluation of Floating Tablets of Verapamil Hydrochloride by using Gastroretentive Technology” by S. R. Dawange, S. S. Khadabadi, S. S. Saboo, India.
... the acidic environment of the stomach. In the intestine, where neutral to slightly alkaline pH conditions prevail; however, precipitation of the active compound occurs, which adversely affects absorption in the lower ...
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FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF GLIMEPIRIDEQuazi Rubiya*,Patil Shivanand,Birajdar ArunadeviDOWNLOAD/VIEW
... retentive dosage forms have been proposed including mucoadhesive systems, swellable and floating ...floating dosage form is useful for those drugs that act locally in the proximal gastrointestinal tract ...
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Formulation and Evaluation of Cefixime Floating Matrix Tablets
... Bioadhesive drug delivery systems (BDDS) are used to localise a delivery device within the lumen to enhance the drug absorption in a site-specific manner. This approach involves the use of bioadhesive polymers, which can ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MUCOADHESIVE TABLETS OF DILTIAZEM HYDROCHLORIDE FOR PROPHYLAXIS OF ANGINA PECTORIS
... solid dosage forms may be achieved by the mechanisms of mucoadhesion, floatation, sedimentation, expansion, modified shape system or by the simultaneous administration of pharmacological agent that delay gastric ...
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FORMULATION AND EVALUATION OF STABLE FLOATING TABLET OF LOSARTAN POTASSIUM FOR ORAL CONTROLLED DRUG DELIVERY SYSTEM
... Oral administration is the most versatile, convenient and commonly employed route of drug delivery for systemic action. Indeed, for controlled release system, oral route of administration has received more attention and ...
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Formulation and evaluation of gastroretentive floating tablets of rebamipide
... In vitro dissolution has been identified as a vital part of drug development. It could be used for assessment of bioequivalence. There are several models to represents the drug dissolution profiles where it is a function ...
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PREPARATION OF HIGHLY POROUS GASTRORETENTIVE QUETIAPINE FUMARATE TABLETS BY USING A SUBLIMATION METHODM.Naga Ganesh*, Jamjala Naveen, T.Mangilal,M.Ravi KumarDOWNLOAD/VIEW
... the dosage form and maintain constant drug levels in the blood The concept of floating tablets is mainly based on the matrix type drug delivery system such that the drug remains embedded in the matrix which after ...
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