GB virus B
Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus
... C virus (HCV) vaccines and affordable antiviral ...HCV/GB virus B (GBV-B) chimeric virus carrying the major nonstructural proteins NS2 to NS4A (HCV NS2 to -4A chimera) was ...
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Virus-Specific Cofactor Requirement and Chimeric Hepatitis C Virus/GB Virus B Nonstructural Protein 3
... GB virus B (GBV-B) is closely related to hepatitis C virus (HCV) and causes acute hepatitis in tamarins (Saguinus species), making it an attractive surrogate virus for in vivo ...
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The Marmoset Model of GB Virus B Infections: Adaptation to Host Phenotypic Variation
... C virus (HCV), and chronic infection frequently progresses to serious liver disease, including cirrhosis and hepatocellular carci- ...noma. GB virus B (GBV-B), the virus ...
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Ribavirin Induces Error-Prone Replication of GB Virus B in Primary Tamarin Hepatocytes
... GB virus B (GBV-B) is the closest relative of hepatitis C virus (HCV) and is an attractive surrogate model for HCV antiviral ...
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Determinants Involved in Hepatitis C Virus and GB Virus B Primate Host Restriction
... C virus (HCV) only infects humans and chimpanzees, while GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primates (tamarins and ...progeny virus in ...
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Lack of Adaptation of Chimeric GB Virus B/Hepatitis C Virus in the Marmoset Model: Possible Effects of Bottleneck
... C virus (HCV). GB virus B (GBV-B), a surrogate model for HCV, causes hepatitis in tamarins and is the virus phylogenetically most closely related to ...chimeric virus ...
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Virus-Specific T-Cell Immunity Correlates with Control of GB Virus B Infection in Marmosets
... C virus (HCV) has been the lack of a convenient small-animal model to test their ...supports virus rep- lication and has been used in studies examining vaccine efficacy (12, 26), but due to the high cost ...
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Mutational Analysis of the GB Virus B Internal Ribosome Entry Site
... GB virus B (GBV-B) is a recently discovered hepatotropic flavivirus that is distantly related to hepatitis C virus (HCV). We show here that translation of its polyprotein is initiated ...
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NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies
... panel B) are highlighted in the respective species-coded colors. (B) The sequences of the indicated six hepacivirus species representatives were aligned with the T-Coffee multiple-sequence alignment tool ...
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GB Virus B Disrupts RIG-I Signaling by NS3/4A-Mediated Cleavage of the Adaptor Protein MAVS
... RNA virus infections, is specifically recognized by TLR3 and/or RIG-I in hepatocytes (20), the major target cell type that HCV and GBV-B infect in ...kappa B (NF- B), transcription factors ...
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Modulation of GB Virus B RNA Abundance by MicroRNA-122: Dependence on and Escape from MicroRNA-122 Restriction
... pression assay based on transient GBV-B replication. Several years ago, a stable replication system was established for GBV-B sub- genomic replicons expressing a neomycin resistance gene (neo), through G418 ...
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Development of a Primary Tamarin Hepatocyte Culture System for GB Virus-B: a Surrogate Model for Hepatitis C Virus
... GBV-B replication in in vivo-infected hepatocytes. One of our major priorities with the GBV-B system was the creation of a tissue culture system that would permit studies that have been difficult or ...
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Identification of a Novel Sequence at the 3′ End of the GB Virus B Genome
... three GB viruses, as shown in ...all GB viruses, includ- ing interaction with host proteins or viral factors necessary for viral replication, polyprotein translation, or viral genome en- capsidation, as has ...
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GB virus B and hepatitis C virus NS3 serine proteases share substrate specificity.
... sequences, with the GBV-B polyprotein sequence. Tentative NS3-dependent cleavage sites within the GBV-B polyprotein, similar to those already proposed (14), are displayed in Fig. 6. Although the homology is ...
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Identification of a Pegivirus (GB Virus-Like Virus) That Infects Horses
... C virus (HCV) and human pegiviruses (HPgV) infect an estimated 2 and 5% of the world’s population, respec- ...as GB virus C or hepatitis G virus), and other genetically related viruses belong ...
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Herpes Simplex Virus Type 1 Glycoprotein B Requires a Cysteine Residue at Position 633 for Folding, Processing, and Incorporation into Mature Infectious Virus Particles
... wild-type gB transiently associates with cal- nexin, Grp78, and calreticulin, in contrast to the cysteine mu- tant gB forms, which remained associated with calnexin, Grp78, and calreticulin for at least 7 ...
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Glycoprotein gB (gII) of pseudorabies virus can functionally substitute for glycoprotein gB in herpes simplex virus type 1.
... To analyze whether PrV gB was able to complement the defect in cell-to-cell spread associated with lack of gB in HSV-1, gB- HSV-1 mutants that had been produced on cells expressing HSV-1[r] ...
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Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis.
... a GB agent-infected tamarin by using representational difference ...agents, GB viruses A and B (GBV-A and GBV-B, respectively), have genomes of 9,493 and 9,143 nucleotides, respectively, and ...
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Hydrophobic Residues That Form Putative Fusion Loops of Epstein-Barr Virus Glycoprotein B Are Critical for Fusion Activity
... of gB fragments containing putative fusion ...different gB proteins are not well ...HSV-1 gB ectodomain X-ray structure (Protein Data Bank file 2gum), are shown on ...HSV-1 gB. Locations of ...
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GB Virus Type C: a Beneficial Infection?
... Because GBV-C was not found to be pathogenic, research interest in the virus waned significantly in the late 1990s. How- ever, studies of the pathogenesis of GBV-C in HIV-infected patients yielded surprising ...
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