γδ T
Celastrol increases osteosarcoma cell lysis by γδ T cells through up-regulation of death receptors
... in γδ T cells in ...between γδ T cells and OS cells has yet to be demonstrated, our study highlights a potentially intriguing capacity of OS cells pretreated with celastrol to influence ...
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Implication of γδ T cells in the human immune response to cytomegalovirus
... Vδ1 T cells, but the latter occurred in some patients ...Vδ3 T cells contained a single pop- ulation with only 1 or 2 CDR3 lengths and accounted for one third of peripheral T ...the γδ ...
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A variant of SCID with specific immune responses and predominance of γδ T cells
... of T cells, and a nor- mal level of NK cells, likely reflecting the consequences of impaired V(D)J recombination for lymphocyte development (Table ...of γδ T ...
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γδ T cells: an immunotherapeutic approach for HIV cure strategies
... Vδ2 T cells were able to expand up to 120-fold in response to PAM/IL-2 ex vivo and reduce viral replication up to 80% in autologous coculture ...that γδ T cells possess antiviral capabilities that ...
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Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus
... of γδ T-cells with ...late-differentiated T-cells within the V δ 2 - population, but only in CMV-seropositive ...- T-cell ...on γδ T-cells during human ageing, similar to that ...
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Circulating γδ T cells in young/adult and old patients with cutaneous primary melanoma
... of γδ T cells in aged people, as evidenced by the reduction of the absolute number of circulating γδ T cells, in partic- ular of the Vδ2 T subset, an altered pattern of cytokine pro- ...
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Development of interleukin-17-producing Vγ2 γδ T cells is reduced by ICOS signaling in the thymus
... killer T (NKT) cells and the recently discovered natural Th17 (nTh17) cells [26, ...by γδ T cells [29] already in the thymus, but little is known regarding its function on these ...of γδ ...
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Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice
... dermal γδ T cells and their production of IL-17A in IL-23–induced skin inflammation in mice (6) and found evidence for their involve- ment in human psoriasis (6, ...
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Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
... abundant γδ T cell subset in human blood, where they typically account for 1-5% of T cells in healthy adults (Kabelitz and He, 2012, Vantourout and Hayday, 2013, Morita, et ...Vγ9Vδ2 T cells ...
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Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells
... (A), γδ T cells (B), and αβ T cells (C) per ...TCR γδ , CD56, and donor-specific HLA antibodies by four-colour FACS ...haploidentical γδ T cells within the HLA-B8 - recipient was ...
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Gamma delta (γδ) T cells: friend or foe in cancer development?
... αβ T cells and its ligand PD-L1 on γδ T cells restrains αβ T cell activa- ...Vδ2 T cell cytotoxicity, whereas the other seven (CLEC2D, NRP2, SELL, PKD2, KCNK12, ITGA6 and SLAMF1) are ...
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γδ T Cells and Their Potential for Immunotherapy
... of γδ T cells in breast cancer, a phase I trial was conducted, in which Zol and low-dose IL-2 were administered to 10 advanced metastatic breast cancer patients who were therapeutically terminal ...Vγ9Vδ2 ...
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Human γδ T cell Recognition of lipid A is predominately presented by CD1b or CD1c on dendritic cells
... human γδ T cells in the immune response against invasive ...resting γδ T cells (mainly Vδ2 T cells) from peripheral ...murine γδ T cells could directly interact with LA ...
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Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection
... epidermal T cells (DETCs) (43, 44). DETCs are the most common skin-resident γδ T cell population and have been reported to rec- ognize a stress-induced self-antigen derived from keratinocytes (46, ...
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Human γδ T Cells Augment Antigen Presentation in Listeria Monocytogenes Infection
... The activation and expansion of γδ T cells was described previously (19,20). Briefly, each well of 24-well plate was coated with 0.5-μg antipan-TCRγδ mAb (Immunotech, Beckman Coulter). After solution was ...
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Immune synapses between mast cells and γδ T cells limit viral infection
... and γδ T cells in ...activate T cells in vitro, we questioned whether this occurs in ...and γδ T cells. As MCs are tissue resident and γδ T cells patrol the skin ...
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Long-term use of interferon-β in multiple sclerosis increases Vδ1−Vδ2−Vγ9− γδ T cells that are associated with a better outcome
... naïve T cells tended to decrease and that of memory T cells tended to increase in SPMS compared with RRMS ...+ T cells in RRMS than in PPMS [24]. In addition, naïve T cells were nega- tively ...
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Expression of regulatory receptors on γδ T Cells and their cytokine production in Behcet's disease
... δ T cells, the co-stimulatory effect of TLR3 ligation has been shown and it is up-regulated after TCR-stimulation and increased IFN-g secretion ...δ T cells before co-stimulation with TLR3 agonists, could ...
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HIV-1-Induced Impairment of Dendritic Cell Cross Talk with γδ T Lymphocytes
... ␥␦ T lymphocyte ...both T lymphocytes (37) and natural killer cells ...␣ T lymphocytes, is also critical for the activation and proliferation of ␥␦ T cells ...␥␦ T cell proliferation ...
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Association of γδ T Cells with Disease Severity and Mortality in Septic Patients
... lacking T cells ( ␥␦ ⫺/⫺ mice) after ...␥␦ T cells had decreased survival times and in- creased tissue damage after cecal ligation and puncture compared with these parameters in wild-type ...␥␦ T ...
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