Gene Deletions
Detection of Gene Deletions by PCR Analysis in a Malaysian Patient with Duchenne Muscular Dystrophy
... Detection of Gene Deletions by PCR Analysis in a Malaysian Patient with Duchenne Muscular Dystrophy ORIGINAL ARTICLE Detection of Gene Deletions by peR Analysis in a Malaysian Patient with Duchenne Mu[.] ...
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Prevalence of pfhrp2 and pfhrp3 gene deletions in Puerto Lempira, Honduras
... Little is known about the extent of pfhrp2 and pfhrp3 deletions in P. falciparum parasites from Honduras, which has the highest burden of malaria in Central America [3]. It was important to monitor if pfhrp2 ...
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Ratio quantification of gene dosage by Agilent 2100 Bioanalyzer for detection of somatic gene deletions
... KRAS gene on CH.12 and an endogenous internal control of the F9 gene on ...KRAS deletions in non-small cell lung cancer (NSCLC) patients, which confirmed our previous expe- ...
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ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
... apparent deletions involving ND4 and CO3 and varia- tions across spinal cord samples as to which gene was more ...mtDNA gene deletions have been reported to increase with aging in human ...
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Gene deletions correlate with the development of alloantibodies in von Willebrand disease
... deletions within the vWF gene. Both patients had severe vWD (type III) and were the only patients among those studied that had inhibitory alloantibodies to vWF. The extent of deletion was similar in both ...
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CRISPR-Cas9 mediated gene deletions in lager yeast Saccharomyces pastorianus
... terminator region (HRM) to complete the double cross over integration (Fig. 3a). These elements were assem- bled into a transformation cassette on pUD526 and the purified integration fragment was used to transform S. ...
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Related individuals with different androgen receptor gene deletions
... Both deletions are 5 kb in length and have one breakpoint within a 200-bp region in intron 5; however, they extend in opposite ...different deletions have arisen at random is extremely low, but the cause of ...
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Gene Deletions by Ends-In Targeting in Drosophila melanogaster
... Cy Sb ⫹ son was picked, and balanced or homozygous stocks were established for chromosome 2 (Figure 3A). Because less than half of the chromosomes collected in gene. A recognition site for the rare cutting ...
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Inter individual differences in the gene content of human gut bacterial species
... Background: Gene content differences in human gut microbes can lead to inter-individual phenotypic variations such as digestive ...whether gene content variation is caused by differences in microbial ...
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Key words
... Neurofibromatosis type I is characterized by intrafamilial and interfamilial clinical variability. A clinical diagnosis of NF1 is unequivocal in most patients, but not in very young children. Some fea- tures of NF1 ...
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Replication-Defective Adenovirus Vectors with Multiple Deletions Do Not Induce Measurable Vector-Specific T Cells in Human Trials
... or gene therapy has been reported by others (14, 20, ...E1 gene deleted (as used in the Step trial ...contained deletions of the adenovirus E1, E3, and E4 genes (8, ...virus gene ...
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Codon Deletions in the Influenza A Virus PA Gene Generate Temperature-Sensitive Viruses
... Codon deletions in PA block the recruitment and transport of PB1 toward the nucleus at a nonpermissive ...the deletions may interfere with the nuclear import of PA or the formation of the PA–PB1 complex in ...
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Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population
... intermediate-sized deletions can also be expected to have important impacts in genome structure or have important functional ...of gene coding regions [3, 4], and such intermediate-sized deletions ...
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Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.
... The E4 region of human Ad5 lies between map units 99 and 91.5 and is transcribed off a single promoter from the l strand (Fig. 1A). This locus expresses at least seven ORFs, the polypeptides of which have been identified ...
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New clinical and molecular insights on Barth syndrome
... Despite the high density of Alu repeats in the TAZ gene, the deletion observed in Pt2 was not mediated by NAHR between Alu elements. In this patient, the genetic rearrangement was found to be more complex than in ...
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Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses
... E3 gene regions (Ad5[E1 ⫺ ]), and these deletions substantially inhibit but do not completely eliminate the ability of these viral vectors to replicate and translate viral proteins ...early gene ...
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Phenotypic and genetic analysis of Lymantria dispar nucleopolyhedrovirus few polyhedra mutants: mutations in the 25K FP gene may be caused by DNA replication errors.
... or deletions (8 and 24 ...or deletions within the 25K FP gene, but in agreement with earlier work on the LdMNPV FP mutants (32, 33) which indicated that the isolates all have BglII restriction ...
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Molecular Engineering of the Autographa californica Nuclear Polyhedrosis Virus Genome: Deletion Mutations Within the Polyhedrin Gene
... californica nuclear polyhedrosis virus gene for polyhedrin, the major protein that forms viral occlusions in infected cells, was mutagenized by introducing deletions into the cloned DNA [r] ...
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Respiratory Syncytial Virus Modified by Deletions of the NS2 Gene and Amino Acid S1313 of the L Polymerase Protein Is a Temperature-Sensitive, Live-Attenuated Vaccine Candidate That Is Phenotypically Stable at Physiological Temperature
... 6 Gene map and temperature stress test of the ⌬ NS2/ ⌬ 1313/1314L virus, which bears ⌬ NS2, ⌬ 1313, and I1314L(CTG) ...(A) Gene map of the ⌬ NS2/ ⌬ 1313/1314L ...
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Mechanisms underlying the EEG biomarker in Dup15q syndrome
... phenotype and beta EEG phenotype in 15q disorders. To infer the extent to which involvement of UBE3A or the GABRB3 / GABRA5 / GABRG3 gene cluster is necessary or sufficient for the beta EEG phenotype in Dup15q ...
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