Gene loss
The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss
... Toll and the TLRs are transmembrane proteins with a charac- teristic domain structure consisting of an extracellular amino-terminal domain containing leucine-rich repeats (LRRs) responsible for pattern recognition and an ...
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Ancient homeobox gene loss and the evolution of chordate brain and pharynx development : deductions from amphioxus gene expression
... increasing gene number in vertebrate evolution, some ancient homeobox genes that were present in the last common ancestor of chordates have been lost from ...developmental gene regulatory networks occurred ...
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Parasites lead to evolution of robustness against gene loss in host signaling networks
... Here, we explore the consequences of parasite interference with host signaling networks on the evolution of the latter. In particular, we would like to understand (i) whether parasite interference can lead to evolution ...
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Models of gene gain and gene loss for probabilistic reconstruction of gene content in the last universal common ancestor of life
... of gene copies) event. Likewise, gene losses can be modeled either as a single event m → 0, or as two classes of events, those of complete gene deletion (1 → 0 gene loss) and ...
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Gene Loss, Silencing and Activation in a Newly Synthesized Wheat Allotetraploid
... of gene loss (Gornicki et ...Acc-2 gene (Faris et al. 2001). The Acc-2 gene was recently shown to be missing from genome A of tetraploid wheat (genome BBAA) while it was present as a single ...
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Two C or not two C: recurrent disruption of Zn ribbons, gene duplication, lineage specific gene loss, and horizontal gene transfer in evolution of bacterial ribosomal proteins
... horizontal gene transfer (HGT) is much more common than previously sus- pected and permeates not only ‘operational’ genes, but also ‘informational’ genes [11], including some components of the translation system, ...
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Transcriptional Compensation for Gene Loss Plays a Minor Role in Maintaining Genetic Robustness in Saccharomyces cerevisiae
... of gene loss, a regulatory network that detects and re- sponds to gene loss may be a large target for mutation with only a weak selection for its ...
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The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss
... drift. Gene loss in free-living organisms may leave them dependent on cooccurring microbes for lost metabolic ...card. Gene loss can provide a selective advantage by conserving an organism’s ...
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Venom Evolution: Gene Loss Shapes Phenotypic Adaptation
... While gene losses are explicitly inferred by the ‘birth and death’ model frequently invoked to drive snake venom toxin evolution [7,13,16], this study is the first to show that differential gene loss ...
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Reduced selection leads to accelerated gene loss in Shigella
... of gene loss may be ...cadA gene encoding the lysine decarboxylase into Shigella flexneri 2a reduces its pathogenicity ...cadA gene from the genomes of Shigella ...specific gene ...
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Sex chromosome to autosome transposition events counter Y chromosome gene loss in mammals
... Y-linked gene loss via gene transposition was thought to be a peculiarity found in an isolated rodent species, but the new data presented here indicate that this compensatory mechanism is wide- ...
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Gene Loss and Error Prone RNA Editing in the Mitochondrion of Perkinsela, an Endosymbiotic Kinetoplastid
... rps12 gene lack stop codons in at least one frame, the mito- chondrial transcription-translation system in this organism, in one way or another, has to cope with a large number of “incorrect” ...
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Retroviral Integration at the Epi1Locus Cooperates with Nf1 Gene Loss in the Progression to Acute Myeloid Leukemia
... This interspecific backcross mapping panel has been typed for over 3,000 loci that are well distributed among all the auto- somes as well as the X chromosome (11). C57BL/6J and M. spretus DNAs were digested with several ...
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After the Duplication: Gene Loss and Adaptation in Saccharomyces Genomes
... Two gene families—one related to quinone reductase, the other related to pirin, a highly conserved nuclear protein of unknown function that is found in animals, plants, fungi, and bacteria—account for eight of the ...
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Comparable Rates of Gene Loss and Functional Divergence After Genome Duplications Early in Vertebrate Evolution
... Gene families follow different patterns of loss, compensation and divergence; when the second ge- nome duplication occurred, some divergent genes had already lost their orig[r] ...
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Gene gain and loss events in Rickettsia and Orientiaspecies
... on gene content ...core gene concatenated tree [24] (Figure 1) or even a phylogenetic tree based on 16S rRNA sequences ...ettsial gene repertoires have different evolutionary ...tial gene ...
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Gene tree parsimony for incomplete gene trees: addressing true biological loss
... Given a gene tree gt and a species tree ST, two formu- lations for the number of losses have been defined. The most commonly used one computes the number of losses by first computing the “homeomorphic subtree” ...
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Recombination between Homeologous Chromosomes in Lager Yeasts leads to Loss of Function of the Hybrid GPH1 Gene
... the loss or gain of gene ...YPR160W gene, which encodes the enzyme glycogen phosphorylase and generates a hybrid gene that does not produce mature mRNA and is nonfunctional due to frameshifts ...
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Identification of nonsense mutation in TMC1 gene inducing hearing loss by clinical exome sequencing
... In this study, one UAE consanguineous family with ARNSHL was recruited. Audiogram analysis showed that both affected individuals have profound deafness (Figure 1). First GJB2 gene mutations which are the most ...
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RAD52-INDEPENDENT MITOTIC GENE CONVERSION IN SACCHAROMYCES CEREVISIAE FREQUENTLY RESULTS IN CHROMOSOMAL LOSS
... Most of the rad52 intragenic recombination events arose by gene conversion accom- panied by an exchange of flanking markers and not by a simple reciprocal exchange betw[r] ...
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