Gene Rearrangements
High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms
... TCRβ/TCRγ gene rearrangements in 33 cases of histiocytic or dendritic cell ...TCRβ/TCRγ gene rearrangements in more than half of LCH, FDCS and HS, which was similar to the previous findings ...
8
T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia Comparative study of T cell receptor gene rearrangement in childhood leukemia
... alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia ...alpha-chain gene rearrangements were demonstrated in only two of 18, ...
9
IgH gene rearrangements as plasma biomarkers in Non- Hodgkin’s Lymphoma patients
... IgH gene rearrangements in DNA purified from plasma in 14 patients in whom no tumor tissue was available (clinical characteristics are described in Supplementary Table ...putative rearrangements ...
8
Fabry disease: six gene rearrangements and an exonic point mutation in the alpha galactosidase gene
... alpha-galactosidase gene in affected hemizygous males from 130 unrelated families with Fabry disease revealed six with different gene rearrangements and one with an exonic point mutation resulting in ...
11
Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia
... The analysis of HCDR3 sequences proved the presence of stereotyped BCR in one-third of Caucasian CLL [28, 30, 31], suggesting the recognition of a common antigenic determinant [35]. We therefore characterized the HCDR3 ...
12
B-cell malignancies: capture-sequencing strategies for identification of gene rearrangements and translocations into immunoglobulin gene loci
... Notes: (A) Summary of the different B-cell neoplasms, the normal cellular counterparts they arise from, and the main translocations involving the iGH locus they harbor (the disease-defining translocations are shown in ...
13
T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... TCR-delta gene and genomic probes, we have analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ...
10
Graffi murine leukemia virus: molecular cloning and characterization of the myeloid leukemia-inducing agent.
... Multiparameter analysis of acute mixed lineage leukemia: correlation of a B/myeloid immunophenotype and immunoglobulin and T-cell receptor gene rearrangements with the presence of the Ph[r] ...
10
Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR
... harbored gene rearrangements of ROS1 and RET, which have recently been recognized as driver genes in lung adenocarcinoma [28–30] but had not been evaluated in East Asian female ...driver gene ...
10
Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors
... Abstract: Improved understanding of molecular drivers of carcinogenesis has led to significant progress in the management of lung cancer. Patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase ...
10
Molecular analysis of iduronate -2- sulfatase gene in Tunisian patients with mucopolysaccharidosis type II
... IDS gene is situated on the telomere of the long arm of chromosome X at region Xq28 ...The gene has 9 exons and produces a transcript of ...IDS gene had been reported in patients with Hunter syndrome ...
6
Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas.
... Transplanted tumors recovered from the same mouse strain and shown to be of independent origin by chromosomal analysis, by the presence of JH immunoglobulin gene rearrangements, or by th[r] ...
10
NTRK gene fusions as novel targets of cancer therapy across multiple tumour types
... NTRK1 rearrangements in PTC are the consequence of the fusion of the TK domain of NTRK1 oncogene with 5-terminal sequences of at least three different ...Region) gene on chromosome 1q25 activate ...TFG ...
9
Deletions in the COL4A5 collagen gene in X linked Alport syndrome Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression
... (COL4A5) gene of 88 unrelated male patients with X- linked Alport syndrome was tested for major gene rearrangements by Southern blot analysis, using COL4A5 cDNA ...COL4A5 gene in the patient ...
14
The mitochondrial genome of the egg laying flatworm Aglaiogyrodactylus forficulatus (Platyhelminthes: Monogenoidea)
... Protein coding genes (PCGs) For most PCGs the ap- plied annotation programs only detected the conserved domains. This worked best for the COI and Cytb genes, whereas ND2 was not detected at all. Thus, most PCGs were ...
8
Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila.
... In an attempt to identify mutations in the Drosophila synaptotagmin gene we have isolated many new rearrangements, point mutations and P element insertions in the 22F1-2; 23B1-2 [r] ...
13
Molecular cytogenetic analysis of Xq critical regions in premature ovarian failure
... frequent gene mutation that can cause the POF phenotype, is the CGG triplet repeat number increasing which denoted that these females are the permutation status ...
8
Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes
... trithorax gene homologue (called MLL, HRX, or ALL-1) has been shown to span the 11q23 breakpoints of these ...this gene is affected in infant acute myeloid leukemia (AML), we have analyzed 26 infant AML ...
10
Clinical outcomes in ALK rearranged lung adenocarcinomas according to ALK fusion variants
... ALK rearrangements and is strongly correlated with FISH results [9, ...fusion gene part- ners of the ALK gene, which can be identified by real time-polymerase chain reaction (RT-PCR) or next-gen- ...
10
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
... constrained by the paucity of information on the genomics of these cancers, which have been investigated primarily through Sanger sequencing of a limited set of candidate genes (8–20). The exception to this is a recently ...
16