Genetic Predisposition to Disease
Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece
... ed genetic risk ...high genetic risk for CHD increase this risk when they move into a high- risk category of a conventional cardiovascular risk factor no more than persons at low genetic risk, ...
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Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes
... the genetic variants associated with T2D, which may promote coronary atherosclerosis and thus resulted in severe ...between genetic variants of fasting glucose and carotid intima-media thickness in the ARIC ...
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Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis
... Alzheimer’s Disease Neuroimaging Initiative (ADNI) acknowledgments: Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of ...
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Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
... s disease; APOE: Apolipoprotein E; APP: Amyloid precursor protein; A β : Amyloid beta; BA24: Brodmann Area 24; BA9: Brodmann Area 9; CEU: Utah Residents with Northern and Western European Ancestry; CHS: ...
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Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin
... There have been 77 causative CDKN2A variants listed in the international melanoma mutation database, eMelanoBase. CDKN2A (OMIM 60160) was the first to be associated with MM risk and is regarded as the major MM ...
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Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.
... aggressive disease, suggested by their younger age at diagnosis, higher rates of lymph node involvement and distant metastasis at diagnosis, and higher mortality rates compared with non-carriers (Tryggvado´ttir et ...
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Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.
... significant disease, it is inevitable that indolent disease will also be detected leading to ...high-risk disease is important to prevent mortality from ...aggressive disease (Castro et al, ...
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Determination of Genetic Predisposition to Patent Ductus Arteriosus in Preterm Infants
... that we identified is likely to be a causative factor for PDA, sequence variations located within the identified haplotype blocks they represent may be etiologic. Our approach has identified a region of interest for ...
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Genetic Predisposition to Ventricular Arrhythmias and. Sudden Death in Hypertrophic Cardiomyopathy
... Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease and a leading cause of sudden death (SD) in the young. Mechanisms and substrates triggering ventricular arrhythmia are still ...
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Physical activity, genes, and lifetime predisposition to chronic disease
... underlying genetic factors that have a favourable effect on both traits [14, 28, ...of disease seen in observational studies may be due to genetic pleiotropy (see ...pre- disease states may ...
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Potential genetic predisposition for anthracycline-associated cardiomyopathy in families with dilated cardiomyopathy
... artery disease and systemic ...artery disease or other identi fi able causes) after treatment with cumula- tive doses of doxorubicin ≤ 450 mg/m 2 and cumulative doses of epirubicin ≤ 600 mg/m 2 (with or ...
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Elite athletes' genetic predisposition for altered risk of complex metabolic traits
... A possible explanation to the underrepresentation of metabolic diseases risk alleles in endurance athletes arising from studies that evaluated the overall risk of athletes for metabolic and cardiovascular disease. ...
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Diagnostic criteria, specific mutations, and genetic predisposition in gastrointestinal stromal tumors
... this disease relies on concordant histology and KIT ...with genetic predisposition have shown that some GISTs or GIST-like tumors are secondary to inactivating mutations of tumor suppressor genes ...
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HIV Associated Polyneuropathy in Resource Limited Settings: Genetic Predisposition and Vitamin Variations
... Prior to CART, the prevalence of PN was approximately 14% among outpa- tients. It ranged from 2% - 35% depending on whether patients had early HIV disease or in the hospital [10] [11]. About 11% - 43% of CART ...
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Genetic predisposition to acute kidney injury – a systematic review
... human genetic variability and its possible associ- ation with AKI were selected for further ...or genetic variability in association with AKI, but focused on chronic renal failure, diabetes, polycystic ...
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Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast
... The GLACIER study recruited patients from participating centers throughout the UK with the aim of identifying predisposition genes for LCIS and/or ILC. Any patients aged 60 or less at the time of diagnosis, with a ...
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Genetic predisposition to ductal carcinoma in situ of the breast
... cancer predisposition alleles originally reported by Easton et ...LCIS) disease (rs2981582-FGFR2, rs3803662- TOX3, rs889312-MAP3K1) with rs889312 showing a stronger association with DCIS (P-trend ...
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Investigating the genetic predisposition for familial haematological malignancies
... In the 1970s a cohort of all patients that were diagnosed with a HM in Tasmania was surveyed with publications in the 1970s and two publications in the 1980s (33, 112, 113). At the time it was appreciated that a number ...
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Bench to bedside review: Understanding genetic predisposition to sepsis
... There has been great interest in exploring polymorphisms in TNF, IL-1, and IL-6 genes and their association with serum concentration of those cytokines and severity of critical illness [19,20]. TNF-α is one of the key ...
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A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population
... 2.3.0) software[33] using 1000 Genomes Project data (Phase 1 integrated data version 3, March 2012) from Chinese and Japanese populations as reference haplotype maps. A pre-phasing technique was applied to SNP array data ...
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