Genetic risk score
Risk prediction for sporadic Alzheimer’s disease using genetic risk score in the Han Chinese population
... (AD) risk by genome-wide association studies (GWAS) in ...SAD risk-associated SNPs were firstly tested in the discovery ...calculate genetic risk score (GRS) in the testing ...
10
Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders
... a genetic risk score test was performed following the method introduced in Purcell et ...sample, genetic risk scores were calculated based on the estimated number of ‘risk ...
21
Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population
... BMI genetic risk score was generated from predominantly Caucasian studies; the wGRSz constructed may not be a true reflection of BMI genetic risk in African ...understand genetic ...
9
Statistical Methods in Genetic Association Studies and a Genetic Risk Score for Predictive Modeling of Disease Risk: from Gene Discovery to Translation.
... of genetic variants with varying effect size that are associated with complex diseases [McCarthy, et ...identified genetic variants is by constructing a genetic risk score (GRS) for ...
226
Genetic risk score and risk of stage 3 chronic kidney disease
... the genetic risk score have been discussed above, ...More genetic markers may be discovered in the future, and incorporation of these markers such as rare genetic variants influencing ...
6
Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score
... increased risk of CRC (aOR ...accurate risk stratification than risk stratification based on each of the variables ...example, risk was ...identified genetic variants carry essentially ...
10
Influence of age on predictiveness of genetic risk score for prostate cancer in a Chinese hospital-based biopsy cohort
... Table 2 shows clinical characteristics and biopsy outcome stratified by age category. Patients were divided into 3 age groups by cutoffs of 60 and 70 years. As expected, PSA level, prostate volume and cancer detection ...
7
Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.
... key genetic loci are close to the cytochrome P450 1A1/2 (CYP1A1/CYP1A2) and aryl hydrocarbon receptor (AHR) genes, which are known to play a functional role in caffeine ...allelic genetic risk ...
7
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
... of genetic risk of schizophrenia and the five quantitative measures of ...calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data ...
7
Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease
... largest genetic risk to develop rheumatoid arthritis (RA) arises from a group of alleles of the HLA DRB1 locus (’shared epitope’, ...aggregate genetic-risk score (GRS) was calculated as ...
8
Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium
... decreased risk of breast cancer (Johansson et al, 2007; Zhao et al, ...SNPs score as main effect; results support that individuals with genetic risk scores in the third tertiles are at ...
10
The polygenic nature of telomere length and the anti-ageing properties of lithium
... polygenic risk scoring we identi fi ed a genetic score which explained ...reported genetic risk score consisting of only genome-wide signi fi cant SNPs that explained just over 1% ...
10
Telomere length and survival in primary cutaneous melanoma patients
... composite genetic risk score, sex, nevus num- ber, tumor localization, and tumor stage showed that the association of patients with short telomeres (compared to patients with long telomeres) with ...
9
Dietary and genetic risk scores and incidence of type 2 diabetes
... and genetic predisposition determine the development of type 2 diabetes (T2D), and studies have indicated interactions between specific dietary components and individual genetic ...on genetic ...
14
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease
... the genetic risk score and CAAD, given the percent variation in HDL and LDL levels explained by the genetic risk score and given the effect size of dyslipidemia as a risk ...
12
Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies
... low genetic risk and the inverse association among those at high genetic ...divergent genetic predispositions might be differently related to adipos- ity according to certain dietary factors ...
9
Resolving the Genetic Etiology of Hypercholesterolemia in Familial Combined Hyperlipidemia
... As part of a collaboration to study patients with clinical FH who were negative for mutations in known genes, 44 Mutation Negative Familial Hypercholesterolemia (FH/M-) patients (cases) and 44 Mutation Positive Familial ...
229
Assessing the incremental contribution of common genomic variants to melanoma risk prediction in two population-based studies
... polygenic risk score for melanoma was higher than has been previously ...phenotypic risk model (Kypreou et ...phenotypic risk model (Fang et ...of risk (<20%, 20%e50%, >50%) was ...
8
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
... the risk of cardiovascular morbidity and ...million genetic variants in up to 72,167 ...independent genetic variants are associated with these traits. A genetic risk score, ...
14
Polygenic risk score: use in migraine research
... Clinical disease prediction of migraine relies exclusively upon existing classification criteria (the International Classification of Headache, third edition [44]) as there are no available objective diagnostic methods ...
10