genetically engineered mouse
The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer
... a genetically engineered mouse model of serous ovarian cancer under obese and non-obese ...cancer mouse model under obese and non-obese ...
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Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN -deficient prostate cancer
... a genetically engineered mouse (GEM) model of PTEN-deficient prostate cancer to evaluate the in vivo pharmacodynamic and antitumor activity of AZD5363 in castration-naïve and castration-resistant ...
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Genetically engineered mouse models and human osteosarcoma
... Rodent models of OS have been established for many decades and were originally generated through the ex- posure to chemical and radioactive carcinogens. [15-17]. These models demonstrated the principle of high- ...
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Hormone induced protection of mammary tumorigenesis in genetically engineered mouse models
... Finally, it is apparent that the preventive activity can be induced by a modest dose of estrogen alone (100 μg) or a combined dose of estrogen and progesterone. Previously we had shown that short-term sustained exposure ...
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Autoantibodies to Ezrin are an early sign of pancreatic cancer in humans and in genetically engineered mouse models
... Methods and results: The serum reactivity of GEM from inception to invasive cancer, and in resectable or advanced human PDAC was tested by two-dimensional electrophoresis Western blot against proteins from murine and ...
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Capturing the Molecular and Biological Diversity of High-Grade Astrocytoma in Genetically Engineered Mouse Models
... However, a recent report utilized the same GFAP- Cre driver line in conjunction with an elegant genetic tag to label cells that had undergone homozygous deletion of Trp53 and Nf1 [63]. These investigators demonstrated ...
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Delivery strategies of cancer immunotherapy: recent advances and future perspectives
... and genetically engineered mouse (GEM) models are three common animal models for studying human disease ...Each mouse model has its own key strengths and ...
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Targeting of interleukin 13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF β and PTEN signaling
... xenograft mouse model using these human HNSCC cell lines and the immunotoxin treatment were well- tolerated by the mice ...a genetically engineered mouse model of head and neck cancer, the ...
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SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG
... and genetically engineered mouse models of SPOP-mutant prostate ...and mouse models where SPOP muta- tion drives prostate neoplasia, ERG is not expressed, and we see no evidence of activation ...
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DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways
... lines, genetically engineered mouse model of mutant BRAF V600E and molecular biology analysis to establish the role of BRAF V600E -mediated-TET inhibition in CpG-island methylator phenotype (CIMP) ...
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Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future
... Besides, genetically engineered mouse models (GEMMs) are also extensively employed for investigating the pathogenesis of ...transgenic mouse glioma model ...transgenic mouse is similar ...
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PubMedCentral-PMC5070672.pdf
... a genetically engineered mouse breast cancer model were acquired to develop an image acquisition and processing routine that isolated radially expanding regions of a 3-D image from the tumor boundary ...
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Mouse models of breast cancer in preclinical research
... and genetically engineered mouse models (GEMMs) are also useful to understand the mechanisms involved in the pathogenesis and molecular processes of breast cancer and ...several mouse models ...
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Mouse models of liver cancer: Progress and recommendations
... GEM, genetically engineered mouse models; miR, microRNA; CSCs, cancer stem cells; DEN, diethylnitrosamine; HBV, hepatitis B virus; HCV, hepatitis C virus; SCID, severe combined immune deficient; ...
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TarGo: network based target gene selection system for human disease related mouse models
... for Genetically engineered mouse models ...predicted mouse gene function with molecular interactions and sorting relationship for phenotype (or disease) signature ...in Mouse Genome ...
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Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer
... a genetically engineered mouse model of pancreatic cancer ...KPC mouse model of ...KPC mouse model of pancreatic cancer, which closely recapitulates the development and progression of ...
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Genes and physiology: molecular physiology in genetically engineered animals
... determinants for complex cardiovascular defects. Similar approaches should be useful for approaching cardiovascular physiological pheno- types in another “developmental” window in the post-natal adult context, i.e., ...
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Genetically engineered nanocarriers for drug delivery
... Notes: (A) ELP nanoparticles fused genetically to the cognate receptor of Rapamycin- FKBP can specifically carry the drug with high avidity. (B) FSI significantly prolongs drug release compared with plain ELP ...
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Pharmacology of Recombinant or Genetically Engineered Drugs
... Etanercept is a genetically engineered, modiÞ ed fusion protein that resembles the cell surface receptor to which TNF-alpha normally binds to exert its actions. It is thus, a cytokine-inhibiting agent, ...
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Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells
... the mouse mammary gland by human fibroblasts pro- motes engraftment of human mammary epithelial cells ...with mouse myoepithelial cells; therefore, we tried to use the mouse myoepithelial layer as a ...
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