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Genome informatics

Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics

Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics

... The genetic dissection of complex disease remains a significant challenge. Sample-tracking and the recording, processing and storage of high- throughput laboratory data with public domain data, require integration of ...

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Plant genome informatics: evaluation and analysis of genomic DNA features involved in the transcriptional processing of protein coding genes

Plant genome informatics: evaluation and analysis of genomic DNA features involved in the transcriptional processing of protein coding genes

... the genome era, frustrating both biologists and bioinformaticians who are forced to spend considerable and often duplicated efforts to sort out annotation errors for their genes of interest or to generate ...

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Inferring gene-to-phenotype and gene-to-disease relationships at Mouse Genome Informatics: challenges and solutions

Inferring gene-to-phenotype and gene-to-disease relationships at Mouse Genome Informatics: challenges and solutions

... Genotypes associated with only a single inserted expressed gene (Fig. 1, box 7) are divided into two types: those expressing a mouse gene and those ex- pressing a non-mouse gene. Genotyp[r] ...

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Foxa2 acts as a co activator potentiating expression of the Nurr1 induced DA phenotype via epigenetic regulation

Foxa2 acts as a co activator potentiating expression of the Nurr1 induced DA phenotype via epigenetic regulation

... Nurr1 (Nr4a2 – Mouse Genome Informatics) is an orphan nuclear receptor expressed in late mDA neuron precursors (Saucedo- Cardenas et al., 1998; Zetterström et al., 1996). Mice lacking Nurr1 lack DA ...

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N cadherin can structurally substitute for E cadherin during intestinal development but leads to polyp formation

N cadherin can structurally substitute for E cadherin during intestinal development but leads to polyp formation

... Mouse Genome Informatics), which activates canonical Wnt signaling and induces proliferation in the intestinal epithelium upon overexpression (Kim et ...Mouse Genome Informatics) which have ...

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Stem cells and their niche: an inseparable relationship

Stem cells and their niche: an inseparable relationship

... Mouse Genome Informatics), a mouse homolog of the Drosophila piwi, is required for GSC maintenance in the mouse ...Mouse Genome Informatics), another mammalian PIWI homolog, which has apparent ...

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The Vertebrate Trait Ontology: a controlled vocabulary for the annotation of trait data across species

The Vertebrate Trait Ontology: a controlled vocabulary for the annotation of trait data across species

... Rat Genome Database (RGD; [13]), Mouse Genome Informatics (MGI; [14]), and the Animal QTL Database (QTLdb; [15]), and it began as a way to standardize descriptions and definitions of quantitative ...

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Coordinating cell behaviour during blood vessel formation

Coordinating cell behaviour during blood vessel formation

... ECs at the leading front of the vascular plexus and found that inhibition of DLL4/notch signalling results in increased vascular density due to excessive sprouting. Similar findings were described in the zebrafish ISV ...

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Cell autonomous requirement for β1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice

Cell autonomous requirement for β1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice

... referred to as ‘Tie2-Cre mutant’) mice were born, indicating that the mutation was embryonic lethal. Since Cre activity is observed as early as e7.5 in our Tie2-Cre line (Braren et al., 2006), we analyzed e8.5 embryos ...

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Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6

Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6

... Mouse Genome Informatics) and Neto1 is reduced (Chow et ...Mouse Genome Informatics) have a reduction of recoverin and Nk3r immunolabeled type 2 cells, and also have a reduction in the total ...

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MALS 3 regulates polarity and early neurogenesis in the developing cerebral cortex

MALS 3 regulates polarity and early neurogenesis in the developing cerebral cortex

... Although MALS-3 does not contain a transmembrane domain, in other systems, it associates with membranes via interactions with other proteins (Roh and Margolis, 2003; Straight et al., 2006). To ascertain whether the ...

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MySeq: privacy-protecting browser-based personal Genome analysis for genomics education and exploration

MySeq: privacy-protecting browser-based personal Genome analysis for genomics education and exploration

... of genome informatics, and particularly the extensive use of command-line software tools, creates barriers to the wider adoption of experiential genomics ...personal genome analysis using only the ...

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Changes in the nuclear deposition of histone H2A variants during pre implantation development in mice

Changes in the nuclear deposition of histone H2A variants during pre implantation development in mice

... Mouse Genome Informatics), H2A.Z, macroH2A1.2 (H2afy – Mouse Genome Informatics), ...Mouse Genome Informatics), and H4 (Hist1h4a – Mouse Genome Informatics) were ...

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Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens

Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens

... Mouse Genome Informatics (MGI) to annotate phenotype data from large- scale data sets, including mouse mutagenesis screens, and from data described in published ...

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Evaluation of a joint Bioinformatics and Medical Informatics international course in Peru

Evaluation of a joint Bioinformatics and Medical Informatics international course in Peru

... medical informatics have been taught over the last 20–25 years, and their successes and setbacks have been well-documented, providing good models for future course development ...in informatics remains one ...

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Publication trends in the medical informatics literature: 20 years of "Medical Informatics" in MeSH

Publication trends in the medical informatics literature: 20 years of "Medical Informatics" in MeSH

... medical informatics literature specifically, bib- liometric studies have been used to characterize sub- domains and components of the field such as, mode- ling[27], computer-based medical records[28], and the ...

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MONITOR-SAST Activity: The needs and possibilities for cooperation between selected advanced developing countries and the Community in the field of science and technology. (Sast Project #1), country report on Brazil, December 1990. EUR 14143 EN

MONITOR-SAST Activity: The needs and possibilities for cooperation between selected advanced developing countries and the Community in the field of science and technology. (Sast Project #1), country report on Brazil, December 1990. EUR 14143 EN

... Article 7 - The Nattonal Council on Informatics and Automation shall : I - advise the President of the Republtc regarding the formulation of the NatiOnal Informatics Policy; II - propose[r] ...

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Informatics LAB 2

Informatics LAB 2

... Make sure that you select Visual C# — and under it, Windows — in the Project Types pane; otherwise Visual Studio may create something like a Visual Basic or Visual C++ application.[r] ...

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A Review on Healthcare Informatics

A Review on Healthcare Informatics

... The opportunities of big data in health care are: (i) Personalized care- Predictive data mining can highlight best practice treatments through early detection and diagnosis an[r] ...

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 Cyberinfrastructure for Chemical Informatics

 Cyberinfrastructure for Chemical Informatics

... A chemist is working on a chemical series for a particular project and wants to know: If anyone publishes anything using the same or related compounds ~ PubChem search Any new compounds [r] ...

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