genome instability
Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability
... The endocycle is a common developmental cell cycle variation wherein cells become polyploid through repeated genome duplication without mitosis. We previously showed that Drosophila endocycling cells repress the ...
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Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae
... Together, these results provide some insight into how genome instability is driven by telomere dysfunction. Erosion of telomeres past a critical length eliminates the protective features that keep telomeres ...
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Human endogenous retroviral elements promote genome instability via non-allelic homologous recombination
... Overall, we have shown that structural variation between HERV elements occurs throughout the genome. Given the reciprocal nature of the CNVs and association with recombination hotspots, they most likely occurred ...
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Analysis Association between Mitochondrial Genome Instability and Xenobiotic Metabolizing Genes in Human Breast Cancer
... The aim of this study was to determine the existence of association between the genetic polymorphisms of metabolizing genes GSTM-1, GSTT-1, and NAT-2, and the presence of mitochondrial genome instability ...
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Extraordinary Genome Instability and Widespread Chromosome Rearrangements During Vegetative Growth
... the accessory chromosomes of Z. tritici are highly unstable during asexual growth across numerous mitotic cell divi- sions (“mitotic growth”) in vitro as well as in planta. Sur- prisingly, increasing the temperature from ...
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Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in Saccharomyces cerevisiae
... to genome instability and increased mutation ...of genome instability is critical to fuel genetic diversification and evolution (Skoneczna et ...
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Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
... whole genome sequencing datasets reveal that anchor points are strongly depleted for single nucleotide variants (SNVs) in ...for genome instability, also show elevated numbers of intersecting loop ...
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A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
... contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale genetic screens in uncovering human disease genes, makes zebrafish an ideal system in ...
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Increased Genome Instability and Telomere Length in the elg1-Deficient Saccharomyces cerevisiae Mutant Are Regulated by S-Phase Checkpoints
... Maintaining genome stability is essential for cell growth and ...of genome instability are generated (16, 20, 44). Such genome instability in mammalian cells further leads to the ...
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Mitochondrial dysfunction leads to nuclear genome instability: A link through iron-sulfur clusters
... nuclear genome instability (Figures 1 and ...entire genome were monitored; and greater than 25% of colonies had large sectors indicative of an LOH event at either of the loci (Figure ...
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Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response
... microsatellite instability (MSI) and immunohistochemistry to assess the altered expression levels of MMR proteins within the tumor that might correlate with a diagnosis of high ...ing genome replication, ...
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Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability
... promoted genome stability by silencing satellite expression by affecting 5-hmC levels in pericentromeric satellite repeats, and LSH was resistant to cisplatin-induced DNA ...of genome instability ...
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A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.
... cause genome instability in KSHV-infected cells, although no mechanism has thus far been ...export, genome instability and cancer ...genetic instability observed is a consequence of ...
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Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability
... V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve ...
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Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.
... tumorigenesis are an outstanding question in the field (Hill et al., 2016). While defective sister chromatid cohesion leading to aneuploidy could drive cancer progression, it is clear that this is not the mechanistic ...
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Genome instability model of metastatic neuroblastoma tumorigenesis by a dictionary learning algorithm
... In conclusion, we propose for the first time a model of carcinogenesis for metastatic NB based on dictionary learning. Our model suggests that an aberrant regula- tion of the endomitosis could correlate to carcino- ...
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DNMTs are required for delayed genome instability caused by radiation
... of the Dnmt knockout mESCs showed a significantly elevated mutation rate in the 3 Gy X-irradiated clones in comparison to their corresponding sham treated controls (p > 0.4) (Fig. 4A). Thus, Dnmt knockout mESCs showed ...
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Stimulation of Chromosomal Rearrangements by Ribonucleotides
... of genome instability have also been observed in RNase H2-defective ...in instability of a nonessential yeast artificial chromosome (YAC loss and terminal deletions) (Wahba et ...This ...
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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase
... on genome stability of gene amplification and/or overexpression, a genome-wide screen for an overexpression-induced mutator phenotype was con- ...to genome instability is a step toward ...
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Histone Chaperone Paralogs Have Redundant, Cooperative, and Divergent Functions in Yeast
... a genome instability phenotype at the ribosomal DNA, which implies that these histone chaperones regulate chromatin structure and DNA access at this ...
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