Genome-wide association analysis
Genome-wide association analysis of body conformation traits in Mexican Holstein cattle using a mix of sampled and imputed SNP genotypes.
... a genome-wide association analysis for a set of sampled and imputed SNPs with 16 conformation traits in a population of Mexican Holstein cows, revealed eight significant SNPs: one associated ...
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Effects of covariates and interactions on a genome wide association analysis of rheumatoid arthritis
... the genome-wide association analysis (GWAA) of RA using Genetic Analysis Workshop 16 Problem 1 data and a logistic regression approach as implemented in ...conducting association ...
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Selection of important variables by statistical learning in genome wide association analysis
... Complex diseases such as coronary heart disease (CHD) are results of failures in complex biological systems. Multiple factors (genetic and environmental) are involved in the etiology; and the disease outcomes most likely ...
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Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.
... A number of genes localize to the region of linkage disequilibrium encompassing rs2686876 (Fig. 3). They include RIC8A, a homolog of C. elegans Ric8/synembryn that encodes a highly conserved G protein regulator. ...
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Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
... tation analysis on these pathways by identifying the top SNPs that map to the pathway genes, and determining if any of these SNPs fall within ENCODE peak data, namely DNase-seq peaks of open chromatin, FAIRE peaks ...
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Genome wide linkage and association analysis of rheumatoid arthritis in a Canadian population
... conducted genome-wide linkage analysis with 128 affected individuals from 60 families in a Canadian cohort that were genotyped using the Illumina linkage panel and genome-wide ...
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GENOME-WIDE ASSOCIATION STUDIES IN PHARMACOGENOMICS
... showed association with many loci in the HLA region ...independent association was also observed at rs2523822 (P = ...with genome-wide significance in combined analysis of the initial ...
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Genome-Wide Association Studies in Glioma.
... The original glioma tagSNP rs2736100 is intronic within TERT, the gene coding for telomerase reverse transcriptase which is primarily involved in telomere length regulation (55). Consistent with a TERT-mediated role in ...
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Comparison of methods for correcting population stratification in a genome wide association study of rheumatoid arthritis: principal component analysis versus multidimensional scaling
... the analysis using trend test indicated a strong PS effect on the association ...the analysis adjusted for the leading MDS dimensions was able to reduce the genomic inflation factor to ...this ...
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Genome wide association studies: a primer
... Pathway analysis represents an alternative analytical approach to interrogating GWAS ...of association with a disorder than other SNPs in the GWAS, or SNPs mapping to other ...
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Genome-wide association studies with metabolomics
... sophisticated analysis methodologies (omics) that allow for the inte- gration of multiple layers of molecular and organismal ...disease. Genome-wide association studies (GWAS), in particular, ...
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Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy.
... pooled genome wide association study (GWAS) performed in prostate cancer survivors demonstrated that it was possible to meta- analyze data and identify genomic risk regions, despite the heterogeneity ...
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Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways associated with TP53 expression status in HBV-related hepatocellular carcinoma
... the association between TP53 expression status and candidate SNPs using the GWAS approach, and validates the association between the genes of the candidate SNPs and TP53 using the Gene Expression Omnibus ...
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On Considering Epistasis in genome Wide Association Studies.
... In brief, it optimizes F = E − TS, where (F) is the free energy which is analogous to relevance of a group of SNPs to the phenotype (in our study this is case/control status). E is determined by statistical interactions ...
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Family based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families
... previous genome-wide linkage study of alcohol dependence in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and ...recent ...
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A Genome Wide Association Study for Longevity in Cattle
... values close to the Bonferroni line, at bp positions 63,641,401 to 64,227,687. This is a gene rich region contain- ing, among others, E2F1 (bp position 63,704,817 - 63,714,008) which has a role in tumor necrosis [38]. ...
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Genome wide scan reveals association of psoriasis.pdf
... Gene expression. We obtained 6 mm punch skin biopsies at the University of Michigan Department of Dermatology. One biopsy of normal skin was obtained from the buttock of 64 control individuals. Two biopsies (one ...
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Genome wide gene based association study
... the analysis of RA data, we also calculated empirical p-values of different combination methods including the minimum p -value statistic and Fisher ’ s product p -value statistic for the top significant ...strong ...
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Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis
... not genome-wide in scale and were limited by small sample ...phenotypic association between COPD and CVD is due to shared genetic and biologic ...
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Genome wide transcriptional analyses in Anopheles mosquitoes reveal an unexpected association between salivary gland gene expression and insecticide resistance
... promoter activity in transgenic fruit flies, where it repro- duced the tissue-specificity of D7r4 expression [13]. Seven sequences derived from five individuals displaying low levels of D7r4 expression (fold change 1–2 ...
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