Genome-wide association studies
GENOME-WIDE ASSOCIATION STUDIES IN PHARMACOGENOMICS
... Addis Ababa University, College of Health Sciences, Department of Pharmacology, P.O.Box 9086, Addis Ababa, Ethiopia *zelalemp@yahoo.com Abstract The aim of this study is to review the applications of ...
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Genome-wide association studies with metabolomics
... Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering ...
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Genome wide association studies in neurology
... Correspondence to: Lan Tan. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, China. Email: dr.tanlan@163.com; Jin-Tai Yu. Department ...
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Genome-Wide Association Studies in Glioma.
... 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma ...assessing association of germline risk SNPs with particular ...
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Recent genome-wide association studies revealed that
... Recently, genome-wide association studies revealed that a genetic variant in the loci corresponding to histone deacetylase 9 (HDAC9) is associated with large vessel ...
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Statistical Approaches in Genome-Wide Association Studies
... in genome-wide association studies the number of markers, p, vastly exceeds the number of observations, n, that breaks down the main assumption in classical ...
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Genome-Wide Association Studies of Allergic Diseases
... genetic studies have been ...conduct genome-wide association studies (GWASs), which is a comprehensive and unbiased approach to identify sus- ceptibility loci for multifactorial ...
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Genetics of migraine in the age of genome-wide association studies
... gene association studies were often negative and positive results were often not replicated or replication ...linkage studies remains unclear owing to the inability to pinpoint the genes under the ...
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Methods of genotype imputation for genome-wide association studies
... of genome-wide association studies (GWAS) that have delivered hundreds of bona-fide associations to complex human diseases (Hindorff et ...
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Regularized regression method for genome wide association studies
... Background Genome-wide association studies (GWAS) are a modern approach to genetic ...delineating association sig- nals by achieving smoothness and reducing randomness in single-SNP ...
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SNP2GO: Functional Analysis of Genome-Wide Association Studies
... ABSTRACT Genome-wide association studies (GWAS) are designed to identify the portion of single-nucleotide polymorphisms (SNPs) in genome sequences associated with a complex ...
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Q&A: Promise and pitfalls of genome-wide association studies
... need genome-wide association studies? To answer that, we first need to look at the kinds of genetic changes that have previously been studied by medical ...
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Genome-wide association studies of childhood bone health
... Health Genome-wide association studies (GWAS) are a technique for researchers to detect genes involved with human ...the genome for small variation, or single nucleotide polymorphisms ...
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A new gene based association test for genome wide association studies
... Abstract Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex ...of genome-wide association ...
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Statistical Modeling and Testing for Joint Association in Genome-Wide Association Studies
... many genome wide association studies (GWASs) have been conducted to explore association of genetic variants with complex diseases using a case-control ...An association study ...
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Genome wide association studies in plants: the missing heritability is in the field
... nested association mapping populations in maize and Arabidopsis ...B: Genome- wide association studies of 14 agronomic traits in rice ...
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The impact of genome-wide association studies on biomedical research publications
... in genome-wide association studies ...follow-up studies may be needed for GWAS to most successfully guide biomedical research toward the molecular mechanisms underlying complex human ...
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Commercially Available Outbred Mice for Genome-Wide Association Studies
... Abstract Genome-wide association studies using commercially available outbred mice can detect genes involved in phenotypes of biomedical ...for association, a situation that has so far ...
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Breast cancer genome-wide association studies: there is strength in numbers
... linkage studies have identified high-penetrance genes, BRCA1, BRCA2, PTEN and TP53, that are responsible for inherited BC ...Recently, genome wide association studies (GWAS) in BC ...
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Meta-Analysis of Genome-wide Association Studies with Overlapping Subjects
... multiple genome-wide association studies are often analyzed together for the purposes of combining information from several studies of the same disease or comparing results across ...
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