genome-wide polygenic score
Clinical Relevance of Genome-Wide Polygenic Score may Be Less than Claimed
... A recent study claimed that genome-wide polygenic scores (GPSs) for five common diseases could identify individuals with risk equivalent to monogenic mutations. Receiver operator curve analyses were ...
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Phenome-wide analysis of genome-wide polygenic scores
... Figure 2. ( a ) Mean for height at age 16 by adult Height genome-wide polygenic score (GPS) septile. The threshold for selecting trait-associated alleles was P T o 0.30. The GPS were converted ...
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Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia
... using genome-wide approaches. We performed a genome-wide association study (GWAS) and polygenic risk score analysis in a Greek sample collection (GOMAP) comprising three patient ...
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Are genetic risk factors for psychosis also associated with dimension specific psychotic experiences in adolescence?
... Findings from twin studies suggest that heritabilities of psychotic disorders are higher than for adolescent psychotic experiences. Estimates of heritability of both schizophrenia and bipolar disorder have been shown to ...
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Polygenic risk score: use in migraine research
... latest Genome-Wide Association Study identified 38 genetic variants associated with ...a Polygenic Risk Score. Polygenic Risk Score has been widely used with success in genetics ...
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Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome wide association and polygenic scoring study
... heritability. Polygenic score analysis uses ensembles of SNPs from a GWAS in a discovery sample, weighted by their log odds ratios to create a score across all these alleles for each individual in an ...
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Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities
... of genome-wide association (GWA) for brain infarcts (BI), white matter hyperintensities, intracranial, hippocampal, and total brain volumes to estimate polygenic scores for these traits in three ...
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Recent quantitative genetic research on psychotic experiences: new approaches to old questions
... One genome-wide significant schizophrenia-associated risk allele (rs17512836, in TCF4) was significantly associ- ated with higher quantitative scores on a paranoia scale in the general population at age 16 ...
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Polygenic risk score for predicting weight loss after bariatric surgery
... been observed in previous studies (25–28). In this regard, the main distinctive feature of the present study resides in its use of genome-wide BMI-associated SNPs, which a priori should warrant an eventual ...
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Migraine polygenic risk score associates with efficacy of migraine-specific drugs
... 1,2 Genome-wide associ- ation studies (GWASs) have been used in many complex diseases to detect genetic variants associated with diseases, and subsequently to generate polygenic risk scores (PRSs), ...
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Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?
... Findings from twin studies suggest that heritabilities of psychotic disorders are higher than for adolescent psychotic experiences. Estimates of heritability of both schizophrenia and bipolar disorder have been shown to ...
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Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.
... (Gleason score <=6, PSA<10, and stage T2N0M0 or lower) were censored at time of diagnosis, reflecting the fact that it is unknown if they would later be diagnosed with aggressive disease or at what age that ...
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Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression
... with information on the SCAN and genoytped on the Illumina 550K platform. From the Munich Antidepressant Response Signature (MARS) project, 549 cases of depression genotyped on the Illumina 610K platform were available ...
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Genome-wide association analysis of body conformation traits in Mexican Holstein cattle using a mix of sampled and imputed SNP genotypes.
... In this paper, we present an association study utilizing 6,912 SNPs obtained using a low-density bovine SNPchip, and 39,611 imputed SNPs along the bovine genome. Association was performed for 16 traits related to ...
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Genome wide associations for milk production and somatic cell score in Holstein Friesian cattle in Ireland
... In total 54,001 biallelic SNPs for 1,957 Holstein-Friesian AI sires with progeny in Ireland were genotyped in this study; the sires were representative of the germplasm used in Irish dairy herds in past years. All animal ...
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Genome-Wide Analysis of a Radiation-Induced Lesion Mimic Mutant in Rice
... JA001 is a variety of LMM derived from rice IR64 using 60COγ–radiation. The mutation begins to appear as yellow–brown lesion mimic spots on rice-plant leaves after the four-leaf stage. Although the ...
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Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle.
... Functional traits, i.e., the length of productive life, health, and fertility, have become increasingly important to the dairy cattle industry. They have a potential effect on the cost of milk production (Groen et al., ...
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Genome-wide analysis of salinity-stress induced DNA methylation alterations in cotton (Gossypium hirsutum L.) using the Me-DIP sequencing technology.
... A genome-wide peak scanning was performed on the basis of a defined analysis model. The lengths of peaks and the number of CpG islands contained in each peak were computed (Figure S1b, 1c). The results ...
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Estimating Polygenic Effects Using Markers of the Entire Genome
... small genome location and forms a test statistic profile after ...entire genome has been ...the genome-wise type I error rate at a desired ...the genome search, the QTL ever, still cannot be ...
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Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy
... Gleason score (≤6, 7(3 + 4), 7(4 + 3), and 8–10), pathological stage (local: pT2, N0/NX, M0; regional: pT3-T4 and/or N1, M0), and diagnostic PSA level (1-unit increase), with a model that included these ...
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