Genomic Epidemiology
Towards understanding the genomic epidemiology of bacterial infections in West Africa
... project. Through these collaborative efforts we hope to gain insights into the genomic epidemiology of S. pneumoniae to guide intervention strategies towards the elimination of this deadly pathogen as a ...
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The PHA4GE SARS-CoV-2 Contextual Data Specification for Open Genomic Epidemiology
... the genomic epidemiology of foodborne pathogens (13, 14) , and has the potential to reveal a deeper understanding of SARS-CoV-2 origin, pathogenicity, and basic biology when submissions from its wild ...
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Genomic epidemiology of a protracted hospital outbreak caused by multidrug-resistant Acinetobacter baumanniiin Birmingham, England
... importations of outbreak strains, often by military pa- tients [7-9]. We have described a prolonged outbreak of MDR-Aci, in which bacterial WGS provided a powerful adjunct to conventional laboratory and epidemiological ...
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Genomic Epidemiology of Congestive Heart Disease, Pharmacogenomics and the Relevant Health Education Implications in the Age of Genomic Medicine
... investigated genomic epidemiology of congestive heart disease, the clinical and non-invasive techniques for diagnosis and the modifiable and non-modifiable risk factors associated with the disease were ...
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Genomic epidemiology of a protracted hospital outbreak caused by multidrug resistant Acinetobacter baumannii in Birmingham, England
... importations of outbreak strains, often by military pa- tients [7-9]. We have described a prolonged outbreak of MDR-Aci, in which bacterial WGS provided a powerful adjunct to conventional laboratory and epidemiological ...
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Genomic Epidemiology of the Haitian Cholera Outbreak: a Single Introduction Followed by Rapid, Extensive, and Continued Spread Characterized the Onset of the Epidemic
... Genomic heterogeneity in the integrative conjugative ele- ment and ToxR-binding repeats. To assess the genome-wide plasticity in the Haiti/Nepal-4 clade, we further analyzed differ- ences in the overall genome ...
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Genomic epidemiology supports multiple introductions and cryptic transmission of Zika virus in Colombia
... measure associations between ZIKV infection and out- comes of interest. In addition, we found that the majority of ZIKV diversity in Colombia descends from one of these two introductions, and rarefaction analyses suggest ...
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Genomic Epidemiology of Penicillin Nonsusceptible Pneumococci with Nonvaccine Serotypes Causing Invasive Disease in the United States
... ABSTRACT Conjugate vaccination against seven pneumococcal serotypes (PCV7) re- duced disease prevalence due to antibiotic-resistant strains throughout the 2000s. However, diseases caused by resistant nonvaccine type ...
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<p>Genomic Epidemiology of an Outbreak of <em>Klebsiella pneumoniae</em> ST471 Producing Extended-Spectrum β-Lactamases in a Neonatal Intensive Care Unit</p>
... WGS. Genomic DNA from the bacterial strains was sequenced using Illumina sequencing by constructing two paired-end (PE) libraries with average insertion lengths of 500 bp and 2000 bp, ...
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Genomic Epidemiology and Molecular Resistance Mechanisms of Azithromycin Resistant Neisseria gonorrhoeae in Canada from 1997 to 2014
... program), genomic islands (deter- mined with the IslandViewer program), and highly recombinant regions containing ⬎ 90 single nucleotide polymorphisms (SNPs) per 10,000 bp, were excluded from the analysis to ...
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Genomic Epidemiology of Clostridium botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia
... All bont/A-carrying isolates had a single chromosomally en- coded BoNT/A2 neurotoxin cluster integrated into the arsC operon integration site (49) (see Fig. S3 in the supplemental ma- terial). Multiple sequence ...
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Genomic Epidemiology of BRCA1/BRCA2; Breast Cancer Associated Genes and Use of Electronic Health Record to Reduce the Escalating Cost of Treatment
... of genomic medicine, the limitations of the primary care physicians and other medical doctors who are not clinical geneticists but are compelled to establish contact with cancer patients must be ...
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Microreact: visualizing and sharing data for genomic epidemiology and phylogeography
... population genomic outputs and associated data in a user-friendly manner for a wide range of end users, from trained bioinformaticians to front-line epidemiologists and health ...
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Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore
... exploiting genomic data from an intensively studied major outbreak, we are able to describe the molecular epidemiology of DENV at a uniquely fine-scaled temporal and spatial ...
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Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England
... Bacterial study isolates and growth conditions. Study isolates are shown in Table 1 (European Nucleotide Archive study accession number ERP009770). Thirteen isolates from other London hospitals were also included to ...
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Whole genome sequence analyses of brain imaging measures in the Framingham Study
... in Genomic Epidemiology; dbGaP = Database of Genotype and Phenotype; eQTL = expression quantitative trait locus; FHS = Framingham Heart Study; FLAIR = fluid- attenuated inversion recovery; GWAS = genome-wide ...
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Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium.
... in Genomic Epidemiology (CHARGE) consortium examining plasma levels of ω-6 (Guan et al, 2014) and ω-3 (Lemaitre et al, 2011) PUFAs in order to identify genetic variants associated with plasma PUFA ...
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Regional outbreak of community associated methicillin resistant Staphylococcus aureus ST834 in Japanese children
... for Genomic Epidemiology; DDBJ: DNA Data Bank of Japan; ERY: Erythromycin; FOX: Cefoxitin; GEN: Gentamicin; MLST: Multilocus sequence typing; OXA: Oxacillin; PCR: Polymerase chain reaction; PFGE: ...
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Comparative genomics of European avian pathogenic E. Coli (APEC)
... These files were downloaded and using the online tools provided by Center for Genomic Epidemiology http://www.genomicepidemiology.org/, used for the following analysis: Single-nucleotid[r] ...
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Long-term integrity protection of genomic data
... Our scenario only considered a single production of genomic data, e.g., at birth. After that, only updated integrity proofs were generated. However, it is foresee- able that advanced sequencing technology will be ...
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