genotoxic damage
Simian Virus 40 Large T Antigen and Two Independent T-Antigen Segments Sensitize Cells to Apoptosis following Genotoxic Damage
... The variation between clonally derived cell lines expressing the same mutant T antigen was less easily explained. The variation did not relate to the levels of T antigens expressed in the individual lines. It is possible ...
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Protective Role of Green Tea Extract Against Genotoxic Damage Induced by Anticancer Drug and Steroid Compound, Separately, in Cultured Human Lymphocytes
... against genotoxic damage induced by a steroid Trenbolone and an anticancer drug Docetaxel in cultured human lymphocytes, both in absence and presence of metabolic activation, using duplicate peripheral ...
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Heavy metal biomagnification and genotoxic damage in two trophic levels exposed to mine tailings: a network theory approach
... Finally, to evaluate the relationship between distinct trophic levels, the CNT was applied [28]. A matrix inter- action was constructed in order to identify the estab- lished links between: (a) the exposed sites (tailing ...
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Quantification of cell-free DNA for evaluating genotoxic damage from occupational exposure to car paints
... DNA damage (assessed by comet assay and cfDNA) as ...of genotoxic damage among the visited workshops, the exact Kruskal- Wallis test was applied, excluding from analysis those having one worker ...
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Micronuclei in the Oral Mucosa as a Measure of Genotoxic Damage in Dental Radiography: A Clinicopathologic Study
... induces genotoxic effects on oral epithelial cells of buccal and palatal mucosa leading to the formation of ...to genotoxic damage as evidenced by increased MN counts in comparison on to the palatal ...
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Protective Effect of Curcumin Against Chlormadinine Acetate Induced Genotoxic Damage In Cultured Human Peripheral Blood Lymphocytes
... Chlormadinone acetate (CMA) is a synthetic progestin. The prolonged use has been reported to be carcinogenic in various experimental animal models. In the present study the effect of CMA was studied along with curcumin ...
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Evaluation of micronuclei in oral epithelium and in peripheral blood of tobacco users:- a cross sectional observational study
... The risk of cancer in SLT users has been attributed to the presence of tobacco specific nitrosamines (TSNAs). In India, SLT processing is performed by individual farmers and small companies with little control over ...
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Genotoxic and Cytotoxic Damage by Cyclophosphamide and Adriamycin as a Response to Treatment in Breast Cancer Patients: Pilot Study
... vitro genotoxic damage using SCE in the A(T1) C1-3 hamster cell line exposed to antineoplastic agents such as Melphalan, Thiotepa, Actinomycin D, Bleomycin, Hycanthone and 5-aza-C, obtaining a significant ...
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Study of the mutagenic effect of tenoxicam and antimutagenic properties of ginger plant extract on root tips of Vicia faba
... DNA damage (Said et ...the genotoxic damage induced by tenoxicam dr ug using the cytogenetic test (chromosomal aberrations and mitotic index) in root tips of Vicia faba ...
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Mitotic death: a mechanism of survival? A review
... In malignant tumours, there is often a population of cells with a DNA content above the diploid value of the so- called stem-line and in many cases a number of high- ploidy cells are evident [51]. The proliferative ...
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... have genotoxic effects both in vitro and in vivo. Furthermore, DNA damage of mouse cells, investigated by the alkaline comet assay and micronucleus test, was significant and none of the tested tissues ...
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p53 dependent ceramide response to genotoxic stress
... p53-independent pathways of apoptosis have been well de- scribed. For example, apoptosis seen in mitogenically activated T lymphocytes from p53 knockout mice occurs in response to DNA damaging agents (75). Bcl-2 ...
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Cytotoxic and Genotoxic Assessment of Citrullus colocynthis
... 2- Cytogenetic analysis (Allium cepa test): We choose to test the cytotoxic and genotoxic effects of three concentrations of aqueous extracts of the wild plant C. colocynthis, representing ¼EC50, ½EC50 and EC50 ...
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Cytotoxic and Genotoxic Assessment of Citrullus colocynthis
... The present study was planned to clarify the cytotoxic and genotoxic effects of aqueous leave ’ s extract of Citrullus colocynthis. Root tip meristems of Allium cepa was treated with different concentrations of ...
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Mechanism of cellular uptake of genotoxic silica nanoparticles.
... Mechanisms for cellular uptake of nanoparticles have important implications for nanoparticulate drug delivery and toxicity. We have explored the mechanism of uptake of amorphous silica nanoparticles of 14 nm diameter, ...
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Mechanism of cellular uptake of genotoxic silica nanoparticles
... DNA damage was observed in the Comet assay in three different cell lines at only 10 μg/ml, at which dose silica particles were found inside the cytoplasm of A549 cells, but not in the nucleus (Figures 2 and ...
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Programming of Cell Resistance to Genotoxic and Oxidative Stress
... repair gene increases resistance to ultraviolet radiation in human cells by selective repair of DNA damage. Expression of yeast but not human apurinic/apyrimidinic endonuclease 458[r] ...
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GENOTOXIC IMPURITIES: AN IMPORTANT REGULATORY ASPECT
... the damage to DNA or chromosomal structure, thereby causing mutations and the process are called as ...potential damage that can be caused by these genotoxic ...in genotoxic impurity and ...
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1. Evaluation of RAPD Technique to Induced DNA Damage by Heavy Metal to Detect the Genotoxic Effect on Mung Bean (Vigna Radiata (L.) Wilczek) Seedlings
... DNA damage in mung bean (Vigna ...DNA damage evaluated by RAPD analysis could be a useful tool for detection of genotoxic effects of different heavy metals on ...
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First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (açaí) in cultured human cells.
... DNA damage in the cells ...the genotoxic evaluation of ...of genotoxic effects of açaí pulp in mouse bone marrow, liver, and kidney cells, by using micronucleus and comet ...
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