Germline development
A systematic molecular genetic approach to study mammalian germline development
... during germline development by use of a viable stain for b-gal activity and a fluorescence activated cell sorter ...mammalian germline development, these cDNA libraries will be pooled to form ...
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The role of Tudor domains in germline development and polar granule architecture
... two germline proteins, Valois and Capsuléen, are components of the Drosophila methylosome and required for germ cell formation (Anne and Mechler, 2005; Cavey et ...in germline specification in the mouse ...
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Caenorhabditis elegans MES-3 Is a Target of GLD-1 and Functions Epigenetically in Germline Development
... studying germline de- Four maternal-effect sterile (mes) genes, mes-2, mes-3, ...prominent germline (Schedl 1997). C. elegans germline germline development in ...al. development ...
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Novel functions of the ubiquitin independent proteasome system in regulating Xenopus germline development
... Fig. 7. Ubiquitin-independent proteasomes inhibit germline development. (A) In situ hybridization showing the expression of pgat in control, and embryos injected with psme1+psme2, psme3, psme4, or all four ...
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skittles, a Drosophila Phosphatidylinositol 4-Phosphate 5-Kinase, Is Required for Cell Viability, Germline Development and Bristle Morphology, But Not for Neurotransmitter Release
... and germline development: The reduction in the appearance of extra bristles associated with socket cells level of sktl transcript results in female sterility, indicat- as a result of the overexpression of ...
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The Drosophila pumilio Gene Encodes Two Functional Protein Isoforms That Play Multiple Roles in Germline Development, Gonadogenesis,Oogenesis and Embryogenesis
... Germline development in higher eukaryotes typically ...from germline precursors called pole cells, which are ing differentiated daughter cells called ...
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Germ cell autonomous Wunen2 is required for germline development in Drosophila embryos
... cell development, we performed a genetic screen for maternal mutations causing defects in this ...homozygous germline clones in heterozygous mothers (Chou and Perrimon, ...homozygous germline clones ...
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Germ plasm specification and germline development in the parthenogenetic pea aphid Acyrthosiphon pisum: Vasa and Nanos as markers
... conserved germline markers Vasa and Nanos, which specifically identified these presumptive germ cells, to investigate whether germ cells were determined during early devel- ...earlier germline marker than ...
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Maternal Dead end 1 promotes translation of nanos1 by binding the eIF3 complex
... exclusive germline expression pattern of dnd1 suggests that it has a conserved role in germline ...zebrafish germline by masking the miRNA-binding site within the nanos 3 ′ ...
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Statistical Methods for Analyzing Drosophila Germline Mutation Rates
... As pointed out earlier, the process of simulating a sample genealogy is similar to that in Gao et al. (2011), with the exception of the gametogenesis stage. The process consists of forward and backward steps. The former ...
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Evidence of a dual function in fl(2)d, a gene needed for Sex-lethal expression in Drosophila melanogaster.
... We suggest that the requirement of fl(2)d for the female germline development is related to its involvement in SxZ splic- ing, so that infl(2)d homozygous germ cells the[r] ...
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Sex and the TEs: transposable elements in sexual development and function in animals
... during germline development; however the targeted TE families are still to be discovered for most of the KRAB- ZNF members ...the germline [80], an alternative model has been proposed for the ...
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Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc
... The second aspect of this study that requires clarification is the equivalency of variants seen in mouse Ndn and human NDN. To be more specific, although our studies implicate the T50C coding polymorphism within mouse ...
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Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
... CRC development can be prevented by prophylactic removal of the ...the development of extra-colonic disease in FAP could provide some insight towards a better rationale of treatment as current methods ...
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Protecting and Diversifying the Germline
... for germline and cyst cell differentiation, suggesting a specific role for maintaining the stem cell state in these ...out development (Henikoff et ...
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Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte
... mutant germline clones were readily recognized by the absence of detectable GFP fluorescence throughout the germline, while mosaic cysts exhibited a combination of nuclei with and without ...the ...
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A conserved RNA protein complex component involved in physiological germline apoptosis regulation in C elegans
... the germline in the next generation appear to localize to the Balbiani body (Cox and Spradling, 2003), an oocyte organelle associated with numerous mRNAs (Matova et ...
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Primordial germ cell-mediated transgenesis and genome editing in birds
... On the other hand, there have been many efforts to de- velop non-viral transgenic systems without PGCs, such as sperm-mediated gene transfection [79, 80] and direct microinjection of transgenes into the fertilized eggs ...
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Generating and manipulating transgenic animals using transposable elements
... review to systematically cover that very large field, which really would require a textbook to do the subject justice [1–3]. It can be said, however, that transposons come in two general types (Figure 1). The "copy ...
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Fertility preservation in BRCA mutation carriers—efficacy and safety issues: a review
... in germline BRCA1/2 patho- genic mutation carriers generally follows a two-hit hypoth- esis, the first ‘hit’ owing to the inherited pathogenic mutation of one BRCA allele and the second ‘hit’ owing to the somatic ...
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