Giant cell arteritis
Giant cell arteritis: a review
... A UK Department of Health working group is now evaluating “rollout” of this fast track pathway across the UK. The following are the key areas to address: public awareness, professional awareness, improvement of skills ...
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Giant cell arteritis: pathogenic mechanisms and new potential therapeutic targets
... a greater insight into the pathomechanisms that initiate and sustain vascular inflammation in GCA. Despite the availability of effective biologic agents for other auto- immune conditions, the treatment options for GCA, ...
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Anterior ischemic optic neuropathy due to biopsy-proven giant cell arteritis in Thai patients
... Abstract: Giant cell arteritis is a systemic granulomatous vasculitis affecting medium to large ...loss. Giant cell arteritis is very rare among ...
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Giant cell arteritis: immune and vascular aging as disease risk factors
... for giant cell arteritis GCA displays a stringent tissue tropism for certain vascular ...wall cell populations may contribute to disease initiation and the composition of the vessel wall may ...
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Giant cell arteritis: the importance of immediate and appropriate diagnosis and treatment for better prognosis
... from giant cell arteritis (also known as Horton’s arteritis or temporal ...of giant cell arteritis and the efficacy of early steroid therapy in this vascular autoimmune ...
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Characteristics of patients with giant cell arteritis who experience visual symptoms
... Permanent vision loss is one of the most serious complications of giant cell arteritis (GCA) and therefore prompt diagnosis is paramount. However, diagnosis of GCA remains challenging due to its ...
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Giant cell arteritis: new concepts, treatments and the unmet need that remains
... This is an exciting time for the management of giant cell arteritis (GCA). The National Institute for Health and Care Excellence (NICE) and NHS England have approved Tocilizumab (TCZ), an IL-6 ...
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Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis
... Giant Cell Arteritis (GCA) is the most common form of vas- culitis in people over 50 years of age, and has a predilection for medium- and large-sized vessels of the head and ...
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The effect of clinical features and glucocorticoids on biopsy findings in giant cell arteritis
... Patients who had a biopsy before treatment was initi- ated were more likely to have inflammatory infiltrates than those biopsied at a later time point. There was no significant difference in the distribution of ...
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Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study
... persisted for more than 5 years after diagnosis, but we did not compare rates before and after stopping. A previous study using CPRD found a much lower relative risk (1.09) of wrist fracture in glucocorticoid users [3]; ...
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Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling
... GCA: giant cell arteritis; HC: healthy control; IL: interleukin; INF: interferon; NGF: nerve growth factor; NT: neurotrophin; NT-3: neurotrophin-3; NTR: neurotrophin receptor; PCR: polymerase chain ...
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Incidence of giant cell arteritis in Western Norway 1972–2012: a retrospective cohort study
... We also performed the analyses for the extended co- hort of 881 patients who were clinically appropriately di- agnosed as having GCA in the study period, regardless of fulfillment of ACR criteria. This resulted in a ...
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Tongue Necrosis Secondary to Giant Cell Arteritis: A Case Report and Literature Review
... Giant cell arteritis (GCA) is a form of vasculitis involving medium- and large-sized arteries, which mainly affects the extracranial branches of the internal and external carotid arteries, ...
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Chronic periaortitis (retroperitoneal fibrosis) concurrent with giant cell arteritis: a case report
... of giant cell arteritis at a very early clinical stage, in a 47-year-old Greek woman with coexistence of retroperitoneal fibrosis who was admitted to our hospital with a history of high-grade fever ...
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Interleukin 6: a promising target for the treatment of polymyalgia rheumatica or giant cell arteritis?
... Giant cell arteritis (GCA) is a type of vascu- litis of large-sized and medium-sized arteries affecting people aged over ...mononuclear cell in fi ltrate, disruption of the internal elastic ...
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The prevalence of giant cell arteritis and polymyalgia rheumatica in a UK primary care population
... Cases of GCA and PMR were identified through a GP data- base review. All individuals aged ≥ 55 years were included. An age cut-off of 55 years was used for pragmatic reasons as cases of GCA and PMR are rare at younger ...
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Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study
... Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly and can cause irreversible blindness and aortitis. Varicella zoster (VZ), which is potentially preventable by ...
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Is vascular endothelial growth factor a useful biomarker in giant cell arteritis?
... Objectives: To assess the performance of circulating vascular endothelial growth factor (VEGF) levels as a tool for diagnosing giant cell arteritis (GCA) in a cohort of patients referred for ...
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Diagnostic Value of High Resolution MR Imaging in Giant Cell Arteritis
... Fig 1. Enlargements of 3T transversal postcontrast fat-suppressed T1-weighted SE image of the superficial temporal arteries of 4 different patients representing typical images of each grade of the 4-point ranking scale. ...
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A genome-wide association study identifies risk alleles in plasminogen and P4HA2 associated with giant cell arteritis
... During the last decade, genome-wide association studies (GWAS), in which common genetic variation across the whole genome is interrogated in a hypothesis- free fashion, were a breakthrough in biomedical research ...
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