Ginsenoside Rg1
The effects and mechanism of ginsenoside Rg1 on myocardial remodeling in an animal model of chronic thromboembolic pulmonary hypertension
... myocardium, ginsenoside Rg1 significantly attenuated the development of myocardial fibrosis ...[12]. Ginsenoside Rg1 could also possibly ...
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Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl 2 Beclin1 complex
... Cells were seeded in 96-well plates (2 × 10 4 cells per well). After 48 h, cell viability was measured using the 3-(4,5)- dimethylthiahiazo (−z-y1)-3,5-diphenytetrazoliumromide (MTT) assay at different time points (30, ...
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Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy
... amount of P. ginseng and Radix Astragali and other frequently prescribed traditional Chinese medicines such as Shenqi Jiangtang Granules should be applied to avoid complica- tions in DM patients. Some evidences show that ...
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Ginsenoside Rg1 nanoparticle penetrating the blood–brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction
... mortality. Ginsenoside Rg1 (Rg1) has a wide variety of therapeutic values for central nervous system (CNS) diseases for the neuron protective ...restricts Rg1 in reaching the ...of Rg1 ...
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Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization
... [25]. Ginsenoside Rg1 (Rg1, structure shown in Figure 1A), one of major active components of Ginseng, has been widely reported to possess neurotrophic and neuroprotective activities against injuries ...
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Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction
... 5. Ginsenoside Rg1 inhibited FoxO1 activation dependent on ...with Rg1 for 2 h, Akt consensus sequence (PAS) and Akt phosphorylation in FoxO1 protein were determined by immunoprecipitation and ...
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Original Article Ginsenoside Rg1 protects steroid-induced osteonecrosis of the femoral head in rats by suppressing oxidative stress and adipogenesis
... of ginsenoside Rg1 (Rg1) in preventing steroid-induced osteo- ...an Rg1 group. Each group included 15 rats. In the model and Rg1 groups, a high dose of methylprednisolone acetate (40 ...
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Original Article Ginsenoside Rg1 alleviates pulmonary inflammation caused by cigarette smoke-induced COPD
... Abstract: Ginsenoside Rg1, the major effective component in ginseng, has been reported to have potent anti- inflammatory ...of Rg1 on pulmonary inflammation caused by exposure to cigarette smoke (CS) ...
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Original Article SIRT6/NF-κB signaling axis in ginsenoside Rg1-delayed hematopoietic stem/progenitor cell senescence
... Ginseng is an important drug of supplementing qi in traditional medicine, with the effects of benefiting qi and nourishing blood, lengthening life and enhancing immunity; our previous study found that: Ginsenoside ...
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The Beneficial Effect of Ginsenoside Rg1 on Schwann Cells Subjected to Hydrogen Peroxide Induced Oxidative Injury
... Ginsenoside Rg1 (GRg1) has been considered to have therapeutic potential in promoting pe- ripheral nerve regeneration and functional recovery after sciatic nerve ...
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Ginsenoside Rg1 and Aluminum Hydroxide Synergistically Promote Immune Responses to Ovalbumin in BALB/c Mice
... of ginsenoside Rg1 and aluminum hydroxide (alum) on immune responses to ovalbumin (OVA) in mice was ...with Rg1, alum, or Rg1 plus ...while Rg1 enhanced both Th1 (IgG1 and IL-5) and Th2 ...
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Original Article Ginsenoside Rg1 activates bone marrow-derived dendritic cells in mice and acts as an effective anti-infection vaccine adjuvant
... Background: Ginsenoside, the active ingredient extracted from Panax ginseng, is reported to enhance immune ...The Rg1 promoted the secretion of inflammatory cytokines in a dose dependent manner, including ...
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Original Article Ginsenoside Rg1 suppressed inflammation and neuron apoptosis by activating PPARγ/HO-1 in hippocampus in rat model of cerebral ischemia-reperfusion injury
... injury. Ginsenoside Rg1 was reported showing distinct neuroprotective effect in cerebral IR injury but the underlying mechanisms are still ...and ginsenoside Rg1’s neuroprotective effect in ...
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Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats.
... of ginsenoside Rg1 in the T2-DM rat were ...after ginsenoside Rg1 ...after ginsenoside Rg1 ...of ginsenoside Rg1 could have clinical therapeutic potential together ...
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Original Article Ginsenoside Rg1 prevents MPP -induced apoptosis of SHSY5Y cells via the inhibition of a Bax-mediated mitochondrial pathway and by suppressing oxidative stress
... 30]. Ginsenoside, such as Rg1, represents the major active ingredient of ginseng, which has been shown to exert a vari- ety of biomedical effects, such as anti-apoptot- ic activity ...study, Rg1 was ...
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The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D Galactose induced aged rat model
... (D-gal)-administration, Rg1-treatment, and D-gal-administration + Rg1-treatment ...and Rg1 treatment, BMSCs were extracted from femoral bone marrow for ...
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<p>Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats</p>
... GS Rg1 treatment enhanced the expression of PGC-1 α , complex III and V ...GS Rg1 on myocardial mito- chondrial biosynthesis in DM rats, indicating that GS Rg1 can be activated by AMPK pathway to ...
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Original Article The aging-delay effects of ginsenoside Rg1 on hemopoietic stem and progenitor cell are related with changes of cell cycle regulating molecule expression
... the Rg1 anti-aging group, and Rg1 aging-delay group showed higher 30d survival rate, CFU-mix, WBC, HCT, PLT, and lower rates of cells in G 1 phase and SA-β-Gal positive cells than their control in the aging ...
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Original Article Protective effect of ginsenoside Rg1 on isoproterenol-induced acute myocardial ischemia in rats
... 50 male healthy Sprague-Dawley rats weighing from 200-220 g were purchased from Shanghai Slac Laboratory Animal Co. Ltd. (Shanghai, China). Animal experiment was carried out in accordance with the Guide for the Care and ...
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The protective effects of ginsenoside Rg1 against hypertension target organ damage in spontaneously hypertensive rats
... of Rg1 on the remodeling of small retinal arteries (Figure ...While Rg1 inhibited this inward remodeling induced by hypertension, the diameter values were ...
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