GLA PROTEIN
Matrix Gla Protein expression pattern in the early avian embryo
... (Matrix Gla Protein) is an extracellular matrix vitamin K dependent protein previ- ously identified as a physiological inhibitor of calcification and shown to be well conserved among vertebrates ...
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Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP
... Gla protein is synthesised by vascular smooth muscle cells, where it inhibits vessel calcification [19], and by leu- cocytes, where it may have a role in modulating immune responses ...
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Attenuate Synovial Fluid Uncarboxylated Matrix Gla-Protein (ucMGP) Concentrations Are Linked with Radiographic Progression in Knee Osteoarthritis
... Matrix Gla protein (MGP), a mineralization inhibitor, present man- ly in bone, cartilage, and vascular smooth muscle, have been associated clinically with conditions of abnormal calcification ...matrix ...
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Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients
... Matrix Gla protein (MGP) is an 11 kDa protein secreted by chondrocytes and vascular smooth muscle cells (VSMCs) ...genetic protein (BMP2), which itself promotes osteoblastic differentiation of ...
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Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease
... (Gla) protein (MGP) is an extracellular matrix protein with wide tissue distribu- tion, not only detectable in the normal blood vessels but also in calcified atherosclerotic plaques ...
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Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
... Matrix Gla protein is a strong inhibitor of VC, as re- vealed by the development of massive VC in MGP knock- out mice [21]. Indeed, MGP is a vitamin K-dependent inhibitor of calcium phosphate precipitation ...
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Matrix Gla protein deficiency causes arteriovenous malformations in mice
... angiogenesis, or endoglin. Matrix Gla protein (MGP) is an antagonist of BMPs that is highly expressed in lungs and kidneys and is regulated by ALK1. The objective of this study was to determine the role of ...
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New biochemical marker for bone metabolism Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease
... noncollagenous protein of mammalian bone. BGP has a molecular weight of 5,800 and contains three residues of the vitamin K-dependent amino acid, gamma-carboxyglutamic acid. We have applied a radioimmunoassay based ...
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Genome wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand
... New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.. Castaño Betancourt MC, Cailotto F, Ke[r] ...
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Genome wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand
... The top SNP for each independent locus was taken for replication in three studies n =4,011: Leiden hand OA studies Genetics osteoARthritis and progression GARP study & the Leiden Longevi[r] ...
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Serum bone gamma carboxyglutamic acid containing protein in primary hyperparathyroidism and in malignant hypercalcemia Comparison with bone histomorphometry
... Abstract Serum bone y-carboxyglutamic acid-containing Gla protein sBGP, a sensitive and specific marker of bone turnover, was measured in 25 patients with primary hyperparathyroidism and[r] ...
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Increase in serum bone gamma carboxyglutamic acid protein with aging in women Implications for the mechanism of age related bone loss
... Because it is unclear whether age-related bone loss results from increased bone resorption, decreased bone formation or both, we measured the serum level of bone Gla-protein (BGP), a specific marker for ...
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High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial
... AC-24: Aortic calcification score; BMI: Body mass index; CAD: Coronary artery disease; CKD: Chronic kidney disease; Dp-ucMGP: Dephosphorylated uncarboxylated matrix gla protein; ESRD: En[r] ...
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VASCULAR DYSFUNCTION IN THE Α GALACTOSIDASE A KNOCKOUT MOUSE IS AN ENDOTHELIAL CELL , PLASMA MEMBRANE BASED DEFECT
... Defective Gla results in multi-organ accumulation of neutral glycosphingolipids (GSLs), especially in the vascular endothelium, with the major GSL accumulated being globotriaosylceramide ...
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Alpha-Galactosidase A p.A143T, a non-Fabry disease-causing variant
... decreased GLA activities and/or increased lyso-Gb3 levels, while most ...normal GLA activity, which has also been observed by other investigators especially in cultured T cells ...decreased GLA ...
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The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression
... Docosahexaenoic acid ethyl ester oil (containing 80% DHA) and gamma-linolenic acid ethyl ester oil (contain- ing 72% GLA) were obtained from Minami Nutrition Company (Edegem, Belgium). C6 rat brain glioma cell ...
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The structural and luminescence properties of strontium borotellurite glass doped with europium and dysprosium
... The structural nature, local network structure, luminescence emission and decay curve, and elemental composition of the undoped and doped strontium borotellurite gla[r] ...
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Effects of solid aerosols on partially glaciated clouds
... This is despite the net in rease in the domain- by the gla iation indire t effe t were dominated by gla iated wide average of the loud fra tion of i e-only and mixed-phase louds, whi h e[r] ...
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The Plio-Pleistocene climatic evolution as a consequence of orbital forcing on the carbon cycle
... This dramatically highlights the impact of geomorphology on terrestrial organic carbon burial, and suggests that the long-term global balance might be different in a context of large gla[r] ...
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Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF receptor p55
... TNF bioassay, 1 ml of transgenic serum neutralizes about 400 ng (40,000 U) of bioactive TNF-a. Due to the lower serum level of the transgenic fusion protein at birth, 1 ml of serum from newborn transgenic mice ...
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