Glioblastoma stem cells
Patient-derived glioblastoma stem cells respond differentially to targeted therapies
... of glioblastoma is, at least in part, attributable to the difficulty in eradicating glioblastoma stem cells ...two cells in four-seven days. The stem cell identity of GSCs was ...
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γ Secretase inhibitor–resistant glioblastoma stem cells require RBPJ to propagate
... Targeting glioblastoma stem cells with g-secretase inhibitors (GSIs) disrupts the Notch pathway and has shown some benefit in both pre-clinical models and in patients during phase I/II clinical ...
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The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
... In fact, with regard to brain glioma patients being cured, a small part of them recurred after a long time. The possible reason might be the elusive GSCs. Theoretically, if GSCs could be fully eliminated, the brain ...
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The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells
... human glioblastoma (GBM), which is a highly aggressive brain tumor that re- lies on angiogenesis for growth and histological progres- sion [20, ...glioma cells additionally induces accumulation of ...
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Sensitivity to PRIMA-1 MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status
... expressing cells with at least 90% knockdown of ...T98G cells decreased MGMT protein levels, suggesting that mutp53 contributes positively to MGMT expression ...
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<p>MicroRNA 145 enhances chemosensitivity of glioblastoma stem cells to demethoxycurcumin</p>
... Currently, miRNAs are reported to regulate cell growth, migration, and invasion of in multidrug-resistant cancer stem cells (CSCs). 23,24 miR-145 is an important miRNA in glioma cell progression, which is ...
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USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells
... USP9X deubiquitinates ALDH1A3. To investigate whether USP9X actually catalyzes the deubiquitination of ALDH1A3, we coexpressed His-ALDH1A3 and HA-ubiquitin with either WT or the C1566A mutant of USP9X in HEK293 ...
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Regression/Eradication of gliomas in mice by a systemically- deliverable ATF5 dominant-negative peptide
... by glioblastoma as well as by glioblastoma stem cells; ATF5 expression in glioblastoma inversely correlates with prognosis; and interference with ATF5 expression or activity causes ...
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RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model
... tumor cells; 2) internalization into brain tumor cells; and 3) releasing the functional moiety (siRNA against luciferase ...tumor cells and glioblastoma stem cells through a ...
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Membrane radiolabelling of exosomes for comparative biodistribution analysis in immunocompetent and immunodeficient mice – a novel and universal approach
... Histograms illustrate the detection of CD47 on exosomes isolated from B16F10 (Exo B16 – murine melanoma), IENS (Exo IENS – murine glioblastoma stem cells), HEK293 (Exo HEK - huma[r] ...
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The miR-26a/AP-2α/Nanog signaling axis mediates stem cell self-renewal and temozolomide resistance in glioma
... GBM: glioblastoma multiforme; GFAP: glial fibrillary acidic protein; GSCs: glioblastoma stem cells; GST-π: glutathione S-transferase π; H&E: hematoxylin and eosin; IB: immunoblotting; ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... glioma cells in vitro, we then evaluated autophagy level in glioma xenograft tumor ...increased cells with loss of cellular integrity (Figure 6C, lower panel, yellow arrows), which are classic signs of an ...
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Targeted therapy of glioblastoma stem-like cells and tumor non- stem cells using cetuximab-conjugated iron-oxide nanoparticles
... GBM cells include increased apoptosis through activation of the intrinsic pathway resulting in elevated cleaved caspase 3 ...tumor cells, and that conjugation with IONPs enhances ...in cells treated ...
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Combination therapy to checkmate Glioblastoma: clinical challenges and advances
... In recent years, a growing number of successful pre-clin- ical agents have failed to show reproducible effects on patient survival [1]. The “Basket trail” approach—testing the effect of one drug on a single mutation in a ...
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Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1
... of cells at the G1 ...these glioblastoma cell lines, regardless of BMPR-IB infection (Figure ...glioma cells are associated with upregulation of the cell cycle kinase inhibitors p21 and p27Kip1, but ...
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Human breast cancer cell lines contain stem like cells that self renew, give rise to phenotypically diverse progeny and survive chemotherapy
... cancer cells is considered to be the best means to study tumor repopulation because it is pre- sumed that, upon long-term cultivation in vitro, cancer cells lose the dynamic characteristics of a ...
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Neoplastic cells are a rare component in human glioblastoma microvasculature
... human glioblastoma, one of the most aggressive forms of human ...that stem-like glioblastoma cells have the capacity to differentiate into functional endothelial cells, and that a ...
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Metabolic alterations induced by attenuated Zika virus in glioblastoma cells
... cancer cells, human malignant U-251 glioblas- toma cells (GBM) were divided into four different groups, which received distinct treatments, including a medium- only specimen (control group—CT), empty OMV, ...
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FOXP3, anovel glioblastoma oncosuppressor, affects proliferation and migration
... on glioblastoma (GB), the most malignant glioma, and GB stem-like cells, the GB subpopulation relevant for tumor perpetuation ...GB stem-like cells, such as proliferation and migration, ...
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Human Cytomegalovirus-Infected Glioblastoma Cells Display Stem Cell-Like Phenotypes
... live cells with a hemocytometer (dead cells were excluded by trypan blue ...million cells in 1 ml were incubated with 5 M CFSE in phosphate-buffered saline (PBS) for 20 min in the ...reaction. ...
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