Glioma stem-like cells
Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting
... of stem-like cells in GBM that have been shown to undergo terminal differentiation in response to growth factor withdrawal and BMP ...on glioma sphere cultures/glioma ...
11
Suberoylanilide hydroxamic acid represses glioma stem-like cells
... of Glioma stem-like cells ...GBM cells were grown in serum-free DMEM/F12 medium/suspension culture for 2 – 14 ...of stem cell-related markers and Vimentin, an astrocytic marker, ...
12
miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3
... and glioma stem-like cells ...GBM cells and ...GBM cells and GSCs and indicate miR128-1 could function as a tumor suppressor in GBM by negatively regulating tumor cell ...
14
CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation
... CCAAT/enhancer-binding protein delta belongs to the CCAAT/enhancer-binding protein (C/EBP) family. The expression of CEBPD protein is regulated by a va- riety of extracellular stimuli, such as IL-1β and tumor necrosis ...
12
LPS alters the immuno-phenotype of glioma and glioma stem-like cells and induces in vivo antitumor immunity via TLR4
... tumor cells, and induce antitumoral effects in certain ...increases glioma cell pro- ...on glioma, and the relationship between bac- terial infection and cancer outcome is ...
11
<p>Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro</p>
... human glioma cells and to determine whether this activity can be manipulated by these NPs depending on their ...human glioma spheroids as a stem- like cells model, we showed that ...
18
Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling
... of glioma stem cells Glioma stem-like cells (GSCs) are a particular group of cells within the glioma ...of stem cells and have been implicated ...
12
Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... two glioma cell lines (U87 glioblastoma cells and GSC11 glioma stem-like cells) were incubated in medium containing either vehicle (control) or ...U87 cells (Figure 2B and ...
14
YB 1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
... LN-18 cells (kindly pro- vided by ...in stem cell-permissive DMEM-F12 medium supplemented with 20 ng/ml of each human recombinant epidermal growth factor (EGF; BD Biosciences, Heidelberg, Germany), human ...
13
Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
... C6 glioma cells (1 × 10 6 ) in 10 μL phosphate-buffered saline (PBS) were injected ...of glioma cells, the rats were randomly di- vided into two groups including the hydrogen inhalation group ...
10
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells
... In the present study, we investigated the short- and long-term effects of HDACi with different class/isoform selectivity on cultured human GBM cells, non-trans- formed glial cells, and glioma ...
13
Comparative Biology of Glioma Stem Cells and Embryonic Neural Stem Cells in Dogs.
... tumor stem cell model classically attempts to explain the observed heterogeneity through epigenetic changes involved in some degree of differentiation between the tumor cells ...tumor stem cell, ...
294
Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo
... The deubiquitinating enzyme Usp9X was shown to be overexpressed in various human cancers, including glioblastoma (Supplementary Figure S1), which supports the notion that deubiquitinating enzymes represent a valid target ...
15
<p>Advances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target?</p>
... endothelial cells; GCs, glioma cells; PAS, Periodic Acid-Schiff; 3D, three- dimensional; GSCs, glioma stem cells; VEGF, vascular endothelial growth factor; VEGFR-2, vascular ...
11
Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
... U251 cells were maintained in DMEM/F12 supplemented with 10% exosome-depleted FBS (EXO-FBS-50A-1, System Bioscience, Mountain View, USA) for 48 h (80–90% conflu- ence), and the culture medium was collected and ...
18
Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and immunopermissive niche
... patient-derived glioma stem cells (GSCs), leading to growth inhibition and prolonged ...suppressor cells (CD11b + Gr1 + ). Consequently, CIR abrogated M2-like immune polarization and ...
15
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo
... Epidemiologic data have revealed that MET, a first-line treatment for type-2 diabetes, can reduce cancer incidence and mortality in certain cancers [15, 16], and increase the number of breast carcinoma patients obtaining ...
14
Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction
... of glioma cells expressing Myc and impaired tumor formation in ...addicted glioma cells induced resistance to glutamine deprivation and imparted sensitivity to glucose ...
14
Making gametes from alternate sources of stem cells: past, present and future
... dent stem cells. Based on recent advances on ovarian stem cells research, it is being understood that the niche gets disrupted by chemotherapy and also with age [103 – ...Resident stem ...
14
Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma
... of cells including neurons, immune cells, stem cells and cancer cells, which are considered to be one of the primary tar- gets of anti-cancer therapy due to their small sizes (40– 100 ...
15