globin genes
Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals
... like globin gene that was lost in eutherians, as proposed by Wheeler et ...β-like globin gene lineage that is ancestral to a group containing both mammalian and bird β-globins with a high posterior ...
22
Analysis of 5' flanking regions of the gamma globin genes from major African haplotype backgrounds associated with sickle cell disease
... gamma-globin genes may account for differences in fetal hemoglobin expression among the three ...fetal globin genes from one beta s-containing chromosome on each of the three major ...
8
Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
... housekeeping) genes, and a gene ...alpha- globin genes in terminally differentiated erythroblasts is accompanied by (i) a substantial increase in the level of transcription of several adjacent ...
19
Genotype phenotype association analysis identifies the role of α globin genes in modulating disease severity of β thalassaemia intermedia in Sri Lanka
... α globin genotype and copy number and known genetic modifiers of haemoglobin F ...α globin gene ...α globin genes in β thalassaemia heterozygotes or α globin gene deletions in β ...
9
Organization of the alpha globin genes in the Chinese alpha thalassemia syndromes
... alpha-globin genes of normals are at two loci located on a ...alpha- globin locus is deleted and the single 3' alpha-globin locus is found on a ...alpha-globin genes on a ...
5
Altitudinal Variation at Duplicated β-Globin Genes in Deer Mice: Effects of Selection, Recombination, and Gene Conversion
... linked genes contribute to fi tness ...b-globin genes of deer mice (Peromyscus maniculatus), which contribute to adaptive differentiation in blood – oxygen af fi nity between high- and low-altitude ...
19
Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA
... human globin mRNA and recovering the single- stranded cDNA from ...gamma globin mRNA and the lack of hybridization to RNA samples containing little, if any, gamma-globin ...gamma-globin ...
8
Activation of the human beta globin promoter in K562 cells by DNA sequences 5' to the fetal gamma or embryonic zeta globin genes
... consistent with the known inactivity of the beta-globin gene in these cells. In contrast, a gamma/beta promoter composed of a gamma fragment spanning positions -408 to -137 joined to the 127-bp beta promoter was ...
8
Coexistence of multiple globin genes conferring protection against nitrosative stress to the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
... 33 The genome of the Antarctic cold-adapted bacterium Pseudoalteromonas haloplanktis 34 TAC125 PhTAC125 contains genes encoding three distinct single-chain 2/2 globins, supporting 35 the[r] ...
46
Polymorphism and Gene Conversion in Mouse α-Globin Haplotypes
... coding regions.. G., 1974 Rodent hemoglobin structure: a comparison of several species of mice. Assignment of orthol- ogous relationships among mammalian a-globin genes by ex- a[r] ...
9
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients
... identical globin chains (namely, the α-like and β-like ...human globin expression needs to be strictly regu- lated aiming to maintain sufficient oxygen levels in all tissues [11, ...fetal globin ...
11
The evolution of haemoglobin gene loci in amniotes
... like globin genes, or by rapid turnover of transcription factor binding sites, thus showing no conservation at sequence level with therian mammals and ...
206
Compensatory increase in alpha 1 globin gene expression in individuals heterozygous for the alpha thalassemia 2 deletion
... these genes (alpha-thalassemia [Thal]) have not been directly ...alpha-globin genes by determining the relative levels of alpha 1 and alpha 2 mRNA in the reticulocytes ...
9
Genetic differences in hemoglobin function between highland and lowland deer mice
... HBB genes were sequenced at 12 ⫻ coverage and the haplotype phase of all variable sites was determined ...-globin genes, we used the same RT-PCR primer pair for HBB-T1 and HBB-T2 (forward: ...
10
Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR
... these genes. Because of the large degree of sequence homology between the genes in the α-globin gene cluster, assays must have high specificity and sensi- tivity to obtain reliable ...α-globin ...
8
Insights Into Terminal Erythropoiesis Influenced By Human Genetic Variation
... 2008). In contrast, adult erythropoiesis normally remains at steady state in the absence of a hematopoietic stressor such as hemorrhage or hemolysis. The first wave, the primitive wave, begins in the yolk sac and yields ...
193
The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate
... Various transcription factors related to erythropoiesis and the regulation of hemoglobin expression have been identified [5, 11]. In this study, the up-regulation of Klf1 and Klf2 was detected in the BM and liver. ...
12
Molecular basis for nondeletion alpha thalassemia in American blacks Alpha 2(116GAG UAG)
... An American black woman was found to have the phenotype of moderately severe alpha- thalassemia normally associated with the loss of two to three alpha-globin genes despite an alpha-globin gene map ...
7
A Large Cohort Study of Genotype and Phenotype Correlations of Beta- Thalassemia in Iranian Population
... DNA genotyping ARMS-PCR method was employed to detect common β-globin genes mutations. 3 DNA sequencing was done by Kawsar Biotech Co, Tehran, Iran (KBC), using BigDye Terminator Kit (Thermo Fisher ...
5
Localization of the site of recombination in formation of the Lepore Boston globin gene
... Boston globin gene formation has been localized at the DNA ...beta-globin genes were used to map the origin of cellular DNA fragments of a patient homozygous for hemoglobin Lepore ...
6