GLP-1
Conservation of glp-1 Regulation and Function in Nematodes
... of GLP-1 homologues. The complete amino acid sequences for Ce-GLP-1, Cb-GLP-1, and Cr-GLP-1 were used in the ...of GLP-1 are, in a contiguous man- ...
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Berberine moderates glucose metabolism through the GnRH GLP 1 and MAPK pathways in the intestine
... peptide 1 receptor (Glp1r) and mitogen activated protein kinase 10 (Mapk10) were significantly up-regulated, in contrast, gonadotropin releasing hormone receptor (Gnrhr) and gonadotropin-releasing hormone 1 ...
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GLP-1 RECEPTOR ACTIVATION-BASED THERAPY; A PROMISING STRATEGY AGAINST ISCHEMIC STROKE
... of GLP-1 are most probably because it is a growth ...(39). GLP-1R agonists are also able to enhance synaptic plasticity, stimulate adult neurogenesis and improve cognitive performance ...
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Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
... maternal glp-1 in sis, examining the penetrance of mutant germline pat- the ...of glp-1(Pro) alleles is highly sensitive temperature in strains with varying doses of glp-1(Pro) ...
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A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics
... active GLP-1R structures, there are a number of differences that need to be resolved for a full understanding of agonist binding and activation ...since GLP-1 straddles the two domains in 5VAI, which ...
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The arcuate nucleus mediates GLP 1 receptor agonist liraglutide dependent weight loss
... vagal GLP- 1Rs could play a role in the acute satiation process ...injected GLP-1 ...AP GLP-1Rs were ...vagal GLP-1Rs in only short-term satiation processes (34, 61, 62) as well as with ...
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Pancreatic GLP 1 receptor activation is sufficient for incretin control of glucose metabolism in mice
... or GLP-1 secreted by the intes- tine actually reaches β cells in active form, rendering uncertain the mechanisms underlying the classical incretin concept (11, ...12). GLP-1 also exerts ...
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Dual elimination of the glucagon and GLP 1 receptors in mice reveals plasticity in the incretin axis
... peptide 1 (GLP-1), which may contribute to the alterations in glucose homeostasis observed in Gcgr –/– ...of GLP-1 receptor (GLP-1R) signaling to the phenotype of Gcgr –/– mice ...
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Original Article Exploration of neuroprotective mechanism of GLP-1 in animal models with Alzheimer’s disease
... Abstract: Objective: To explore the protective mechanism of glucagon-like peptide-1 (GLP-1) in the neurological function of rats with Alzheimer’s disease (AD). Methods: A total of 48 pure inbred SD ...
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Extra Glycemic Impacts of GLP 1 Receptor Agonists: Benefits of a Class Effect?
... All GLP-1 RAs are administered subcutaneously and are effective in improving glycemic control (as meas- ured at the level of glycated hemoglobin [HbA1c]) [35] [37] ...with GLP-1 RAs is ...
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Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
... receptor, GLP-1R, is a G-protein coupled receptor of seven-transmembrane topology [23, 32, 33, ...highest GLP-1R incidence and density in insulinomas [32, 33, 42]. GLP-1R is considerably expressed on ...
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The influence of exendin and GLP 1 on VCAM 1 and ICAM 1 production in endothelium stimulated by TNF α and glycated albumin
... intake. GLP-1 has an important physiological function in augmenting postprandial insulin ...long-acting GLP-1 analogue. A growing body of evidence suggests that GLP-1 may have ...
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GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?
... diabetes. GLP-1 mediates its key insulinotropic effects via a G-protein coupled receptor expressed on β-cells and other pancreatic cell ...of GLP-1 is terminated via enzymatic cleavage by ...
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GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals
... the GLP-1 response to an OGTT or meal is blunted in diabetes [43, ...in GLP-1 secretion in over- weight and obese persons irrespective of glucose tol- erance ...the GLP-1 ...
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The Effect of 6 Weeks Resistance Training and HITT on GLP-1 Gene Expression of Diabetic Rats
... affect GLP-1 levels ...the GLP-1 hormone and, consequently, the GLP-1 receptor is reduced and absorbed by plasma glucose, plasma glucose levels can also be a good indicator of ...
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Study of anti diabetic activity of artesunate as an agonist to glp 1 by molecular docking and in vitro analysis
... peptide 1 receptor (GLP1R) is a receptor protein found on beta cells of the ...of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of ...
5
Original Article Application of self assembling peptide as drug carrier for extending the GLP-1 stability
... of GLP-1 as showed in Figures 2A and ...of GLP-1 exhibited very low probability of forming hydrogen bond with closed pp1 ...of GLP-1 plays an important role in their ...
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Evaluation of an [18F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma
... for GLP-1R (gluca- gon-like peptide type 1 ...produced GLP-1 interacts with GLP-1R to cause the production of insulin in response to ingestion of food ...[2]. GLP-1R is present ...
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<p>GLP-1 mediates the modulating effect of thymoquinone on feeding behaviors in diabetic rats</p>
... and GLP-1 receptor signaling in the CNS, the ICV infusion of Ex 9 – 39 was performed to block CNS GLP-1 ...least 1 week; only rats that had regained more than 90% of their presurgery ...
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Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension
... study, GLP-1 receptor antagonist (exendin-3) abolished the protective effects of DPP-4 inhibitor (sitagliptin) on right ventricular systolic pressure (RVSP) and pulmonary vascular remodeling (PVR) in ...
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