Glucagon-like peptide-2
The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets
... atrophy. Glucagon-like peptide 2 prevented LPS-induced effects, including desquamation of villous epithelium, and in- creased villous height and VCR of the duodenum and ...
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Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients
... concentration of glucose and free fatty acids and the pro- duction of additional hormones, including insulin-like growth factor 1 (IGF-1) [7], which is highly protein bound, most commonly to IGF binding protein 3 ...
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Therapeutic effects of different doses of polyethylene glycosylated porcine glucagon-like peptide-2 on ulcerative colitis in male rats
... p[Gly 2 ]GLP-2, the pharmacokinetics of PEG–p[Gly 2 ]GLP- 2 was ...p[Gly 2 ]GLP-2 and PEG–p[Gly 2 ]GLP-2 is 49 and 202 min in rat, respectively, which is longer ...
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Clinical application of glucagon-like peptide-1 receptor agonists in cardiovascular disease: lessons from recent clinical cardiovascular outcomes trials
... and CV death [1]. On the other hand, the CANVAS pro- gram, in which one-third of patients had no prior history of CV events, demonstrated no significant risk reduc- tion in such outcomes [4]. We therefore speculate that ...
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Hepatic and glucagon like peptide 1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
... Because glucagon is elevated in patients with type 2 diabetes (2) and because normalizing glucagon levels during oral glucose challenge tests improves metabolism (3), blocking hepatic ...
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Sex and estrogens alter the action of glucagon-like peptide-1 on reward
... result, our experiments are not relevant to effects solely mediated by peripheral GLP-1R. Rats were implanted with a guide cannula targeting the lateral ventricle [36] (26 gauge; Plastics One, Roanoke, VA): ±1.6 from the ...
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... There has been significant research and development in pharmaco-therapeutic molecules for management of type 2 diabetes mellitus (T2DM). Diabetes specific nutrition (DSN) intervention and newer hormonal therapies ...
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A novel, long-acting glucagon-like peptide receptor-agonist: dulaglutide
... type 2 diabetes mellitus, who are not achieving satisfactory glycemic control with “combinations of oral glucose-lowering drugs, or such combinations with basal ...
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Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
... In humans, blood concentrations of GLP-1 generally range between 5 pmol/L and 15 pmol/L in fasting state and increase two- to four-folds after food ingestion [10]. More specifically, GLP-1 blood concentrations rise ...
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Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes
... type 2 diabetes patients, and no relationship was evident between release and BMI, indicating that the potency of metformin to trigger GLP-1 release is preserved in obese patients and in patients with type ...
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Glucagon like peptide isolated from the eel intestine: effects on atrial beating
... since glucagon is processed from the OXM in the mammalian intestine (Plisetskaya and Mommsen, 1996), it is plausible to designate this peptide (EI-14) eel OXM ...OXM-like peptide from European ...
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SGLT2 inhibitors or GLP-1 receptor agonists as second-line therapy in type 2 diabetes: patient selection and perspectives
... type 2 diabetes mellitus (T2DM) who are unable to achieve glycemic control with metformin therapy ...include glucagon-like peptide-1 receptor agonists and sodium–glucose cotransporter 2 ...
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Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study
... JK: Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory ...by glucagon-like peptide-1-(7-36) amide in ...
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Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
... type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic ...a 2-4× increased incidence of death from coronary artery ...type 2 diabetes ...
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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
... The SCFAs produced by microbial fermentation of dietary fi bre in the colon have been shown to stimulate the release of the anor- ectic gut hormones peptide YY (PYY) and glucagon like peptide-1 ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... The PTC cell line IHH-4 was obtained from the Japanese Collection of Research Bioresources, Japan. The PTC cell line BCPAP was purchased from the DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (German ...
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Glucagon-like peptide 1 improved glycemic control in type 1 diabetes
... tensive insulin therapy using multiple daily injections of insulin or continuous subcutaneous insulin infusions, Ta- ble 1. In dose-finding studies subcutaneous abdominal injections of vehicle, 0.32, 0.63, or 1.25 µg/kg ...
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Differential effects of glucagon-like peptide-1 receptor agonists on heart rate
... RA: glucagon‑like peptide‑1 receptor agonist; HF: heart failure; HR: heart rate; LAR: long‑acting release; LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome ...
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Liraglutide in the treatment of type 2 diabetes mellitus: clinical utility and patient perspectives
... Type 2 diabetes mellitus (T2DM) is a progressive disease associated with significant morbidity and ...control. Glucagon like peptide-1 (GLP-1) is an incretin hormone secreted from the small ...
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Serum Glucagon-Like Peptide-1 Changes in Women with Type 2 Diabetes Following a Four Weeks Aerobic Exercise
... Glucagon-like peptide-1 (GLP-1) is produced primarily by the intestine in response to caloric intake mainly from carbohydrates and fat. It increases insulin secretion in a glucose dependent manner, ...
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