glucocorticoid receptor
Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
... human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR ...of glucocorticoid-responsive genes by binding to specific glucocorticoid ...
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Glucocorticoid receptor gene polymorphisms in hereditary angioedema with C1-inhibitor deficiency
... enhanced glucocorticoid sensitivity ...(glucocorticoid receptor beta) splicing ...(glucocorticoid receptor alpha) function, and the altered GR α /GRß ratio may lead to relative ...
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Developmental and hormonal regulation of glucocorticoid receptor messenger RNA in the rat
... The biological action of glucocorticoids is dependent upon tissue-specific levels of the glucocorticoid receptor (GR). During stress, the hypothalamic-pituitary-adrenal axis is stimulated, and high levels ...
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A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function
... The ubiquitously expressed glucocorticoid receptor (GR) is a major drug target for inflammatory disease, but issues of specificity and target tissue sensitivity remain. We now identify high potency, ...
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Primary cortisol resistance in man A glucocorticoid receptor mediated disease
... the glucocorticoid receptor in the white cells and fibroblasts of these ...the glucocorticoid receptor was found to have reduced affinity for ...reduced receptor number was found as ...
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Insight into glucocorticoid receptor signalling through interactome model analysis
... the glucocorticoid receptor ...high glucocorticoid efficacy and widespread usage in medicine, resistance, disease relapse and toxicity remain factors that need ...of glucocorticoid signalling ...
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Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells
... Human small cell lung cancer (SCLC) is highly aggressive, and quickly develops resistance to therapy. SCLC cells are typically insensitive to glucocorticoids due to impaired glucocorticoid receptor (GR) ...
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Insight into glucocorticoid receptor signalling through interactome model analysis
... the glucocorticoid receptor ...high glucocorticoid efficacy and widespread usage in medicine, resistance, disease relapse and toxicity remain factors that need ...of glucocorticoid signalling ...
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Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development
... the glucocorticoid receptor (GR) plays a crucial role during embryogenesis, since this ligand-activated transcrip- tion factor is required for maturation of vital organs such as the lung, heart, kidney, gut ...
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Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis
... The therapeutic response to glucocorticoids can depend on the functional condition of the glucocorticoid receptor (GR). Side effects of glucocorticoids, such as Cushing syndrome, bone mineral loss, ...
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Disruption of eyelid and cornea development by targeted overexpression of the glucocorticoid receptor
... ABSTRACT Glucocorticoid hormones act through the glucocorticoid receptor (GR) and they affect almost all physiological systems in the organism. We have previously reported that transgenic mice ...
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Glucocorticoid receptor beta increases migration of human bladder cancer cells
... anti-inflammatory glucocorticoid signaling point to a pathway that may impact bladder ...the glucocorticoid receptor (GR) isoform signaling that may lead to bladder ...
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Repression of DNA-Binding-Dependent Glucocorticoid Receptor-Mediated Gene Expression
... The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes including energy metabolism and the immune response through DNA-binding-dependent and -independent ...to ...
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Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol dependent individuals
... disability; therefore, effective treatments are urgently needed. Here, we demonstrated that the glucocorticoid receptor (GR) antagonist mifepristone reduces alcohol intake in alcohol-dependent rats but not ...
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
... In eukaryotic cells, the nucleus contains the DNA, which is organized by folding into nucleosomes and higher order structures along each chromosome. The nucleus is a highly organized organelle and contains several ...
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Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
... in glucocorticoid receptor-ligand binding affinity in the propositus, and a lesser reduction in affinity in his mildly affected son and ...nephew. Glucocorticoid receptor cDNA from these three ...
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Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
... In animal models, prenatal and postnatal stress cause long-term elevations in hypothalamic – pituitary axis (HPA) reactivity and anxiety-like behaviors. These effects are mediated via altered glucocorticoid ...
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Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling
... Inflammation is a complex cascade of adaptive cellular responses to injurious stimuli, which occurs in many cardiovascular diseases (1). Vascular inflammation is manifested in several ways, including enhanced expression ...
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Characterization of Serum and Glucocorticoid Kinase Isoforms and a Membrane Glucocorticoid Receptor in the Euryhaline Tilapia (Oreochromis mossambicus): Implications in Salinity Adaptation.
... of glucocorticoid action (Fiol et ...the glucocorticoid receptor, as the increase in transcript levels is not blocked by RU486, a known antagonist (Shaw et ...
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Case control study of glucocorticoid receptor and corticotrophin releasing hormone receptor gene variants and risk of perinatal depression
... Past history of depression and family history of mental illness remain the two strongest predictors of perinatal depression [21]. Given the role of the hypothalamic- pituitary-adrenocortical (HPA) axis in the aetiology ...
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