glucose transporter type 4
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene
... normal glucose tol- erance, a strong correlation has been shown between GLUT4 protein abundance in skeletal muscle and the rates of glucose disposal during insulin clamp studies (16, ...lin-stimulated ...
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A 2-month exposure to dietary genistein has sex-dependent effects on serum profile, cardiac protein expression, and aortic morphology in mice
... cardiac glucose transporter type 4 (GLUT4) was increased in male hearts treated with genistein, while expression of endothelium nitric oxide synthase was significantly increased in females fed ...
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Association of retinol binding protein 4 and insulin resistance: a review on molecular mechanisms
... PI3P; Glucose Transporter Type 4: GLUT4; Phosphoenolpyruvate carboxykinase: PEPCK; Type 2 diabetes mellitus: T2DM; Cellular retinol-binding protein: CRBP; Scavenger receptor class B ...
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Association of glucose transporter 4 genetic Polymorphisms with obstructive sleep apnea syndrome in Han Chinese general population: a cross-section study
... impaired glucose tolerance of OSAS patients was higher, impaired fasting glucose reflecting basal in- sulin level secreted from β-cell is affected, and Punjabi [38] showed that severe OSAS is associated ...
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Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes.
... The glucose transporter 4 (GLUT4) gene ...a glucose transporter, which can be found in adipose, skeletal, and cardiac tissues, and is known to be an insulin-responsive glucose ...
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Human Cytomegalovirus Activates Glucose Transporter 4 Expression To Increase Glucose Uptake during Infection
... for 4 h and then either left untreated or treated with insulin and ...the 4 h of serum starvation; for insulin stimulation, cells were refed with DMEM containing 100 nM insulin for 10 min after the 4 ...
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Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus
... increase glucose uptake through activation of this pathway [127, 128, ...increasing glucose uptake in muscle cells and adipocytes by promoting translo- cation of GLUT-4, mainly via induction of the ...
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Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte dependent glucose sensors
... mice was reduced to the level found in control mice after ganglionic blockade with chlorisondamine (chlori). Chlorisondamine did not change the glucagonemia of control mice. (C) Plasma glucagon levels measured at the end ...
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Oxygen-Dependent Transcriptional Regulator Hap1p Limits Glucose Uptake by Repressing the Expression of the Major Glucose Transporter Gene RAG1 in Kluyveromyces lactis
... represses glucose uptake in ...of glucose transporter genes in ...in glucose trans- port. We then determined the rate of glucose uptake in ...of glucose (10 mM) was used in the ...
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Early effects of sodium-glucose co-transporter 2 inhibitors in type 2 diabetes: study based on continuous glucose monitoring
... Among the T2DM patients admitted to the University of Occupational and Environmental Health, Japan between May 2014 and June 2016, who were being treated with an SGLT2 inhibitor, we selected 24 subjects who had under- ...
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An Intron Variant of SLC2A9 Increases the Risk for Type 2 Diabetes Mellitus Complicated with Hyperuricemia in Chinese Male Population
... acid transporter as well as a glucose ...maintaining glucose and uric acid ...dual transporter for fructose and uric acid, it is necessary to investigate whether there are genetic variants of ...
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Characterisation of BHK 21 cells engineered to secrete human insulin
... lacked glucose transporter In this study BHK-21 cells were chosen as a type 2 (GLUT2) expression (the other main com- recipient cell line for the human insulin ...the glucose sensing system in ...
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Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives
... in glucose uptake, as well as lactate output (indicat- ing glycolytic flux), during ischemia–reperfusion ...to type 2 diabetes and in ob/ob obese mice (a model of type 2 diabetes with altered ...
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Altered placental development in undernourished rats: role of maternal glucocorticoids
... Higher levels of maternal GCs and downregulation of HSD11B-2, may disrupt several essential developmental processes [6], including placenta through increased local GC levels that will affect placental weight and ...
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Ketogenic dietary therapy for epilepsy and other disorders: current perspectives
... The classical KD described in the early studies was based on a ratio of ketone-producing foods in the diet (fat) to foods that reduced ketone production (carbohydrate and protein). Seizure control in children was found ...
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A Novel Treatment for Type2 Diabetes Mellitus: Canagliflozin
... of glucose in the urine, thereby bringing down the blood sugar levels, with mechanism totally independent from pancreatic beta cell activity or gastroin- testinal manipulation of ...
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Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man
... G2 glucose transporter to determine the distribution of glucose transporter messenger RNA (mRNA) in rat and human ...two type II diabetic patients. A very homologous glucose ...
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The role of melatonin in the onset and progression of type 3 diabetes
... that glucose metab- olism is regulated by the circadian system [135, ...abnormal glucose metabolism triggers aberrant circa- dian rhythms [42, ...blood glucose levels and in- creases in the ...
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Jia Wei Jiao Tai Wan ameliorates type 2 diabetes by improving β cell function and reducing insulin resistance in diabetic rats
... Once activated, InsR binds to IRS-1 and activates its phosphorylation. Serine phosphorylation of IRS-1 has been proposed as a general mechanism for the func- tional inhibition of the IRS-1 protein, and Ser307 phos- ...
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Pathophysiological mechanism behind diabetic cardiovascular disorders
... Diabetes, obesity and insulin resistance are associated with subclinical inflammation characterized by over expression of cytokines produced by adipose tissue, activated macrophages and other cells. Inflammatory ...
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