Glutamate transporter
Loss of function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria
... of glutamate and aspartate in the kidneys and intestines of ...neuronal glutamate transporter and buffers the synaptic release of the excitatory neurotrans- mitter glutamate within the ...
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The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells
... the glutamate transporter EAAT2 in glioma ...extracellular glutamate is transported back into glioma cells and also by normal astrocytes at the peritumoural ...preventing glutamate mediated ...
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Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures.
... major glutamate transporter for clearing synaptic ...upon glutamate treatment in a transporter activity-dependent ...that glutamate increases GLT-1 surface diffu- sion in the astrocyte ...
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Cellular distribution of a high affinity glutamate transporter in the nervous system of the cabbage looper Trichoplusia ni
... the transporter by the glial cells at individual neuromuscular ...insect glutamate transporter appears to be most highly expressed in glial processes between these ...the transporter protein ...
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Small molecule activator of glutamate transporter EAAT2 translation provides neuroprotection
... Glial glutamate transporter EAAT2 plays a major role in glutamate clearance in synaptic ...from glutamate-mediated excitotoxic injury and death via EAAT2 ...
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Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice
... this transporter contributes to the maintenance of the redox balance out of the cell ...cystine/glutamate transporter is induced by various stim- uli, including electrophilic agents like diethyl ...
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Upregulation of Glutamate Transporter 1 by Clavulanic Acid Administration and Attenuation of Allodynia and Hyperalgesia in Neuropathic Rats
... Neuropathic pain is a challenge in clinical practice. The recommended drugs for the pain have many side effects with limited efficacy. Clavulanic Acid (CLAV) is a member of β-lactam antibiotics, such as penicillins and ...
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Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes
... on glutamate homeostasis in the spinal ...of glutamate in the spinal cord of Zucker diabetic fatty (ZDF) rats using in vivo ...of glutamate transporter-1 (GLT-1) in the spinal cord of ZDF rats ...
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Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice
... JA, Yu D, Scharf JM, Chan E, Kassam F, Moya PR, Wendland JR, Delorme R, Richter MA, Kennedy JL, Veenstra‑Vanderweele J, Samuels J, Greenberg BD, McCracken JT, Knowles JA, Fyer AJ, Rauch SL, Riddle MA, Grados MA, Bienvenu ...
9
The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity
... Extracellular glutamate con- centrations in the CNS are regulated by a family of high-affinity, Na + -dependent glutamate ...the glutamate transporter GLT-1 (also known as EAAT-2) and ...
12
L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation
... Figure 6 did not cause the downregulation of glutamine synthetase (GS) in our preliminary experiment (data not shown), suggesting that this regulation is GLAST or L-Glu transporter-specific. The comparison of the ...
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Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens
... VGLUT1 is primarily expressed in cortical structures, and it has been shown that the NAc receives gluta- matergic inputs from the PFC and hippocampus in particular [3]. Interplay between hippocampal and PFC ...
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Glutamate transporter type 3 attenuates the activation of N methy D aspartate receptors co expressed in Xenopus oocytes
... of glutamate neurotransmission by EAATs is not effective in all ...the glutamate receptors or a small quantitative ratio of EAATs/glutamate ...of glutamate from the total glutamate pool ...
8
Involvement of the glutamate/glutamine cycle and glutamate transporter GLT 1 in antidepressant like effects of Xiao Yao san on chronically stressed mice
... of glutamate transporters EAAT1–2 have at least two functions, including the clearance of EAA from the synaptic cleft, and the supplying of Glu to glu- tamine synthetase for Gln synthesis ...
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Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression
... to Flinder Sensitive Line rats (FSLs), a genetic model for depression, and longitudinal behavioral and molecular changes were monitored. FSL rats treated with MSC-EAAT showed attenuated depressive-like behaviors ...
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Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphoma
... transporter can mediate cellular uptake of cystine to en- hance biosynthesis of glutathione, which has a major role in the protection of cells from drug-induced oxidative stress by mediating detoxification of ...
12
Expression and purification of recombinant vesicular glutamate transporter VGLUT1 using PC12 cells and High Five insect cells
... obtainable glutamate-filling of the pure vesicles is reached using a buffer containing 50 mM ...of glutamate (120 mM) did not increase (or decrease) the amount of glutamate trapped in the vesicles, ...
8
Transport mechanism of a glutamate transporter homologue GltPh
... and release order of the ligands. Protein data bank (PDB) codes are in parentheses. The helical HP structure in red is HP2 and the blue one is HP1. The purple circles represent Na + ions binding at Na1, Na2 and Na3. The ...
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The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
... 1: Glutamate transporter; HD: Huntington ’ s disease; HSE: Heat shock element; HSF1: Heat shock transcription factor 1; Hsps: Heat shock proteins; HSR: Heat shock response; Htt: Huntingt[r] ...
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The role of glutamate transporters in glutamate homeostasis in the brain
... PDC-sensitive glutamate transporter near the synapse may play a key role in terminating synaptic transmission (although desensitization of postsynaptic receptors also contributes significantly: Takahashi et ...
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