Glycogen-Synthase
Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle
... Muscle glycogen synthesis was reduced by approximately 80% in diabetic rats (P less than ...treatment. Glycogen synthase activity was reduced in skeletal muscle of diabetic rats (P less than ...
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Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle
... changed glycogen phosphorylase ...regulates glycogen synthesis by a mechanism that involves dephosphorylation of glycogen synthase but not ...low glycogen synthase activities ...
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Intracellular glucose oxidation and glycogen synthase activity are reduced in non insulin dependent (type II) diabetes independent of impaired glucose uptake
... mmol/liter. By raising the concentration of either serum glucose or insulin fourfold in the NIDDM subjects, glucose uptake was matched to nondiabetic subjects (8.62 +/- 0.49 and 8.59 +/- 0.51 mg/kg FFM per min, ...
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Impaired insulin stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity
... glucose oxidation was determined by indirect calorimetry. After insulin stimulation, glycogen synthase activity was correlated with the total and nonoxidative glucose disposal at both low (r = 0.73, P less ...
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Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase Evidence for their role in oxidative and nonoxidative glucose metabolism
... of glycogen synthase (GS), phosphofructokinase (PFK), or pyruvate dehydrogenase (PDH) in skeletal muscle regulates intracellular glucose metabolism, subjects were studied basally and during euglycemic ...
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Pre eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles
... of glycogen breakdown ...in glycogen content (223 +/- 117 micrograms glycogen/mg protein), when compared with controls matched for gestational age at delivery (23 +/- 18 micrograms glycogen/mg ...
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Correlation between muscle glycogen synthase activity and in vivo insulin action in man
... muscle glycogen content, and muscle glycogen synthase activity in 25 southwest American Indians with normal glucose tolerance and with varying degrees of glucose ...Muscle glycogen content and ...
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Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non insulin dependent diabetes mellitus
... Total glycogen synthase activity was reduced approximately 38% and glycogen content was approximately 30% lower in ...between glycogen content and glycogen synthase activity (r = ...
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Insulin resistance is associated with reduced fasting and insulin stimulated glycogen synthase phosphatase activity in human skeletal muscle
... Insulin-stimulated glycogen synthase activity in human skeletal muscle correlates with insulin-mediated glucose disposal rate (M) and is reduced in insulin-resistant ...insulin-stimulated glycogen ...
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Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0
... The glycogen synthase (GS) activity has been low or immeasurable in liver biopsies, whereas the liver glycogen content has been only moderately ...
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Mechanism of enhanced insulin sensitivity in athletes Increased blood flow, muscle glucose transport protein (GLUT 4) concentration, and glycogen synthase activity
... We examined the mechanisms of enhanced insulin sensitivity in 9 male healthy athletes (age, 25 +/- 1 yr; maximal aerobic power [VO2max], 57.6 +/- 1.0 ml/kg per min) as compared with 10 sedentary control subjects (age, 28 ...
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The traditional Chinese formulae Ling gui zhu gan decoction alleviated non alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules
... of glycogen phosphorylase liver type (PYGL) and inhibited the activity of glycogen synthase (GS) in NAFLD rats, resulting in glycogenolysis increase and glycogen synthesis decrease in the ...
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3d qsar and molecular docking studies on anilino pyrimidine and anilino quinazolines as kinase inhibitors
... the glycogen synthase kinase (GSK 3β) and EGFR tyrosine kinase ...selective glycogen synthase kinase is an important for improved therapeutic profile of gsk3β inhibitors over tyrosine ...
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Cellular mechanisms of insulin resistance
... muscle glycogen syn- thesis in patients with type 2 diabetes (see Pessin and Saltiel, this Perspective series, ...or glycogen synthase activity will not be as effective in improving insulin sen- ...
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Defective insulin response of cyclic adenosine monophosphate dependent protein kinase in insulin resistant humans
... Insulin-stimulated glycogen synthase activity in human muscle correlates with insulin- mediated glucose disposal and is reduced in insulin-resistant ...for glycogen synthase ...
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Defective insulin response of phosphorylase phosphatase in insulin resistant humans
... and glycogen synthase activities in muscle biopsies obtained during a 2-h hyperinsulinemic euglycemic clamp in 12 insulin-sensitive (group S) and 8 insulin-resistant (group R) ...
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SYNTHESIS & PREDICTING THE POSSIBILITY OF 2, 5 DISUBSTITUTED 1, 3, 4 OXADIAZOLE DERIVATIVES AS GSK 3β INHIBITORS
... A new series of 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives were synthesized using appropriate methods & structures of the synthesized compounds were confirmed by IR,NMR & Mass spectral data.. These ligands ...
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Relationship between skeletal muscle insulin resistance, insulin mediated glucose disposal, and insulin binding Effects of obesity and body fat topography
... Skeletal muscle sensitivity and responsiveness to insulin and their relationship to overall glucose disposal and insulin binding were determined in 89 premenopausal women of varying body fat topography (waist/hips girth ...
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Inhibitory interactions of Coenzyme Q10 with selected key enzymes of glucose metabolism: An in silico approach
... Loss of glycemic control plays an important role in the induction of short and long term diabetic complications that have a wide prevalence around the globe. Hence, it is necessary to explore the effectiveness of ...
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Exercise modulates postreceptor insulin signaling and glucose transport in muscle specific insulin receptor knockout mice
... insulin. Glycogen content and glycogen synthase activity in resting muscle were nor- mal in MIRKO mice, and exercise, but not insulin, increased glycogen synthase ...and glycogen ...
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