Glypican-3 (GPC3)
Role of Serum Glypican 3 in the Diagnosis of Hepatocellular Carcinoma in the Upper Egypt
... The glypican-3 (GPC3) is one of the glypican families of glycosyl phosphatidyl inositol (GPI)-anchored heparan sulfate proteoglycans [16], which plays an im- portant role in cellular growth, ...
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Development and Validation of a Two-Site Immunoradiometric assay for Glypican-3 in plasma: Implication in Diagnosis of Hepatocellular Carcinoma
... plasma glypican-3 (GPC3) in comparison with a commercial ELISA kit and to use them to evaluate the diagnostic potential of GPC3 in HCC ...in 3 groups, 150 HCC patients, 150 hepatitis-C-virus (HCV) ...
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Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican 3 in hepatocellular carcinomas
... Liver cancer is the leading cause of cancer death world- wide and is the second leading cause of cancer death in men [1]. As hepatocellular carcinoma (HCC) is the most common liver malignancy, the molecular mechanism of ...
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Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells
... Glypican-3 (GPC3), a proteoglycan involved in the regulation of proliferation and survival, has been associated with cancer. In this study we observed that the expression of GPC3 is opposite to the ...
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Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer
... that Glypican-3 (GPC3) is absent in invasive tumors and metastatic lymph nodes, in particular in aggressive and highly disseminated signet ring cell ...
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Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma
... CEA (pCEA), MOC-31, CD10, and α-fetoprotein (AFP), have been used to differentiate HCC from other tumors and to evaluate prognosis [4–18]. Glypican 3 and HepPar1, for example, are useful in distinguishing ...
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Original Article Value of the combined detection arginase-1 and glypican-3 expression in distinguishing hepatocellular carcinoma from metastatic tumors
... and glypican-3 (GPC-3) was separately specific markers for HCC, how- ever, the value of Arginase-1-Glypican-3 (Arg1-GPC3) combined staining in distinguishing hepatocellular carcinoma ...
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Expression of Glypican 3 in low and high grade urothelial carcinomas
... Background: Glypican-3 (GPC3) is an oncofetal protein which is encoded by GPC3 gene and takes role in the regulation of cell division and apoptosis. Overexpression of GPC3 has been reported in some types of ...
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Can glypican-3 be a disease-specific biomarker?
... Glypican-3, also called OCI-5, DGSX, GTR2-2, MXR7, SDYS, SGB, SGBS, and SGBS1, was identified in a rare undifferentiated epithelial cell line OCI-5 [9]. It is a cell surface heparan sulfate proteoglycan ...
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Expression of glypican 3 in placental site trophoblastic tumor
... Background: Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that functions in embryonic cell growth and differentiation and is highly expressed in the ...
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EXPRESSION OF GLYPICAN-3(GPC-3) AND 8-HYDROXYDEOXYGUANOSINE (8-OHDG) IN CHRONIC HEPATITIS C AND RELATIONSHIP WITH HEPATOCELLULAR CARCINOMA
... In our study, Glypican-3 was expressed in 9 (18 %) of 50 cases of chronic hepatitis, all of high grade hepatitis(42.9%) and non of low grade chronic hepatitis. The staining pattern was exclusively ...
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Influence of Glypican-3 as a Newly Diagnostic Biomarker in Early Detection of Hepatocellular Carcinoma Among Saudi Patients
... serum Glypican-3 and AFP levels has been detected as HCC after 6 months of follow ...that Glypican-3 could be used for screening and early diagnosis of HCC among CLC ...
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Original Article Immunohistochemical expression of glypican 3 in endometrial carcinoma and correlation with prognostic parameters
... ican 3 mouse monoclonal antibody (1:200, clone IG 12, Cell Marque, Burlington, VT, ...Finally, 3, 3-diaminobenzidine as the substrate or chromogen was used to form an insoluble brown ...
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Diagnostic performance of alpha-fetoprotein, lens culinaris agglutinin-reactive alpha-fetoprotein, des-gamma carboxyprothrombin, and glypican-3 for the detection of hepatocellular carcinoma: a systematic review and meta-analysis protocol
... Glypican-3 (GPC-3) is a heparin sulfate proteoglycan that interacts with several growth factors by binding to the cell membrane via glycosylphosphatidylinositol anchors [31,32]. Because GPC-3 ...
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Original Article HCRP1, ID4 and Glypican-3: an optimal panel of biomarkers for diagnosis of hepatocellular carcinoma
... and Glypican-3 (GPC-3) was performed in 98 cases of HCCs, 15 large regenerative nodules arising in cirrhotic livers, 12 hepatocellular adenomas (HCA), 10 focal nodular hyperplasias (FNH), and 20 ...
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Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe
... (including glypican-1 [GPC-1], glypican-5 [GPC-5], golgi membrane protein-1 [GOLM-1] and dickkopf-like-1 protein [DKK-1]) were over-expressed in a human embryonic kidney cell line (HEK293T) through the ...
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Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling
... Cells in six-well plates were washed twice with ice-cold PBS, and total RNA was extracted using Trizol reagent according to the manufacturer’s instructions. The purity and concentra- tion of RNA were measured using a UV ...
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Expression of oncofetal antigen glypican-3 associates significantly with poor prognosis in HBV-related hepatocellular carcinoma
... than 3 cm to cancer focus) and 69 distal cancerous-tissues (more than 5 cm ) specimens [33] after surgical operation were obtained from Affiliated Hospital of Nantong University between Jan 2006 and May ...
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Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy
... homologue 3; EVs: extra- cellular vesicles; GPC1: glypican 1; GPC3: glypican 3; HCC: hepatocellular carcinoma; HCPCF: hollow core photonic crystal fiber; HCR: hybridization chain reaction; ...
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Glypicans: proteoglycans with a surprise
... that glypican-3 (GPC3) is mutated in an overgrowth and dysmorphic ...this glypican may interact with signaling pathways that have not been tradi- tionally associated with membrane-bound ...
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