Graft-versus-Leukemia
Alloantigen expression on non hematopoietic cells reduces graft versus leukemia effects in mice
... Allogeneic hematopoietic stem cell transplantation (HSCT) is used effectively to treat a number of hemato- logical malignancies. Its beneficial effects rely on donor-derived T cell–targeted leukemic cells, the so-called ...
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Differential roles of IL 1 and TNF α on graft versus host disease and graft versus leukemia
... in graft-versus-host disease (GVHD) after experimental bone marrow transplant (BMT) when cyclophosphamide (Cy) is added to an otherwise well- tolerated dose (900 cGy) of total body irradiation ...P815 ...
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Differential requirements for myeloid leukemia IFN γ conditioning determine graft versus leukemia resistance and sensitivity
... recipient leukemia cells, thereby mediating the graft-versus-leukemia (GVL) effect ...causing graft- versus-host disease (GVHD) ...myelogenous leukemia (CP-CML) is ...
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IL 11 separates graft versus leukemia effects from graft versus host disease after bone marrow transplantation
... lethal graft-versus-host disease (GVHD) in a murine bone marrow transplantation (BMT) model of GVHD directed against MHC and minor ...a graft-versus-leukemia (GVL) ...from ...
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Original Article Effects of regulatory dendritic cells on graft-versus-host disease and graft-versus-leukemia in mice after allogeneic bone marrow transplantation
... acute graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) in leukemia mouse model after allogeneic bone marrow transplantation (al- ...irradiation), leukemia, ...
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Selective graft versus leukemia depends on magnitude and diversity of the alloreactive T cell response
... induce graft-versus-leukemia (GVL) reactivity against malignant hema- topoietic cells from the patient ...life-threatening graft-versus-host dis- ease (GVHD) ...the graft can ...
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LPS antagonism reduces graft versus host disease and preserves graft versus leukemia activity after experimental bone marrow transplantation
... Acute graft-versus-host disease (GVHD) and leukemic relapse remain the two major obstacles to successful outcomes after allogeneic bone marrow transplantation ...and ...
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HIF 1α inhibitor echinomycin reduces acute graft versus host disease and preserves graft versus leukemia effect
... Acute graft-versus-host disease (aGVHD) remains a major obstacle against favorable clinical outcomes following allogeneic hematopoietic stem cell transplantation ...weakening graft- ...
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Characterization of T cell repertoire in patients with graft versus leukemia after donor lymphocyte infusion
... myelocytic leukemia after al- logeneic bone marrow transplantation has been demon- strated in several recent ...this graft-versus-leukemia (GVL) effect, the influence of DLI on the T cell ...
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PD L1 interacts with CD80 to regulate graft versus leukemia activity of donor CD8+ T cells
... preserving strong graft-versus-leukemia (GVL) effects in allogeneic and xenogeneic murine GVHD models. Depletion of donor CD4 + T cells increased serum IFN-g but reduced IL-2 concentrations, leading ...
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Recipient type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft versus host disease while maintaining graft versus leukemia
... Although the possibility of controlling GVHD with Treg’s has been described, the immune reconstitution, which still represents a major challenge for allogeneic HSCT, has not been analyzed. After allogeneic BMT in ...
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The immunogenetics of chronic graft versus host disease and its relevance for the graft versus leukemia effect.
... The debate whether (chronic) graft versus host disease (cGvHD) after bone marrow transplantation reduces the chance of leukemic relapse is certainly not definitively settled, but the maj[r] ...
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Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation
... lymphoblastic leukemia (ALL), as well as non-malignant diseases, such as metabolic disorders and immune deficiency syndromes ...beneficial graft-versus-leukemia (GvL) effect where ...
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Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party
... Acute graft-versus-host disease; allo-SCT: Allogeneic hematopoietic stem cell transplantation; AML: Acute myeloid leukemia; ANC: Absolute nuclear cells; ATG: Anti-thymocyte globulin; BM: Bone marrow; ...
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A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia
... stronger graft versus leukemia effect [1, ...for graft-versus-host disease (GvHD) prophylaxis for T- replete Haplo-SCT contributed to reduce GvHD incidence and to increase the use of ...
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Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies
... control leukemia, mainly through the graft-versus-leukemia (GVL) ...life-threatening graft- versus-host disease (GVHD), associated with infusion of a high number of T cells in ...
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The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party
... the graft-versus-leukemia (GVL) effect, otherwise ex- pected at higher level with mismatched donor T ...mM-URD versus the 10/10 M-URD groups, while higher incidence of ex- tensive chronic GVHD ...
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Allogeneic cellular immunotherapy for chronic B-cell leukemia
... Allogeneic stem cell transplantation following reduced-intensity conditioning is being evaluated in patients with advanced B-cell chronic lymphocytic leukemia (CLL). The curative potential of this procedure is ...
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Clinical significance of high-dose cytarabine added to cyclophosphamide/total-body irradiation in bone marrow or peripheral blood stem cell transplantation for myeloid malignancy
... myelogenous leukemia; BMT: bone marrow transplantation; CBT: cord blood transplantation; CI: confidence interval; CY: cyclophosphamide; GVHD: graft-versus-host disease; GVL: graft ...
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Acute graft versus host disease
... eral recent excellent reviews [16,17]. However, a few guid- ing principles can be stated. The most important is that it is critical to have an experienced transplant immunoge- neticist review all genetic data. Second, ...
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