Group 2 innate lymphoid cell
Bcl11b is essential for group 2 innate lymphoid cell development
... B cell leukemia/lymphoma 11b (Bcl11b) was also reported to be up-regulated in ILC2s, but its role remained undefined (Wong et ...T cell commitment and main- tenance (Avram and Califano, ...double-negative ...
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Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust
... Th17 cell medi- ated airway inflammatory responses [9, 18], allergic asthma is characterized by a type 2 response involving eosinophils, type 2 helper T (Th2) cells, group 2 ...
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Innate Immune Cell Regulation of Metabolic Homeostasis
... Figure 4. Obese white adipose tissue (WAT) is characterized by type 1 cytokine- associated immune responses. In obese WAT, adipocyte hypertrophy is associated with hypoxia and adipocyte cell death. Dead and ...
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Innate lymphoid cells and the skin
... Group 2 innate lymphoid cells contribute to inflammation in mouse models of AD-like inflammation. hK14mIL33tg mice in which IL-33 is expressed under the keratin 14 pro- moter developed ...
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Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity
... house. Experiments were terminated when mice lost a significant proportion of their original weight (>20%); however, mice that succumbed to infection died naturally. All experiments were performed according to ...
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Plasmacytoid dendritic cells promote HIV 1–induced group 3 innate lymphoid cell depletion
... Figure 2). We found that ILC3s were efficiently devel- oped in all lymphoid organs of humanized mice including spleen, mesenteric lymph node (mLN), peripheral lymph node (pLN), BM, and peripheral blood ...
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Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model
... asthma [6, 7]. In asthma patients, elevated levels of C3a and C5a were detected in the airways following allergen challenge [8]. While C3a signaling aggravates AHR [9] and drives allergic inflammation in different asthma ...
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Seasonal variation in circulating group 2 innate lymphoid cells in mugwort-allergic asthmatics during and outside pollen season
... the CD4+ CD8-TCR α β + phenotype, and the majority exhibited a Th2 cytokine profiles [18]. In contrast, house dust mites (HDM) are a type of common, persistent, and perennial allergen that is present almost everywhere in ...
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Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis
... a lymphoid lineage; however, they share expression of Thy1, the common gamma chain (γc), and IL-7Rα ...common lymphoid progenitors (CLPs) in the fetal liver and adult bone marrow, relying upon the ...
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Group II innate lymphoid cells and microvascular dysfunction from pulmonary titanium dioxide nanoparticle exposure
... ILC: Innate lymphoid cells; KC/GRO: Keratinocyte chemoattractant/human growth-regulated oncogene; KLRG-1: Killer cell lectin-like receptor subfamily G member 1; Lin: Lineage; MCP-1: Monocyte ...
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MHCII Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
... T cell proliferation (Figure 4A; Fig- ure ...T cell proliferation (Figure ...T cell proli- feration (Figure ...T cell proliferation (Figure ...
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The origin and role of innate lymphoid cells in the lung
... helper innate lymphoid precursor; CLPs, Common lymphoid progenitors; COPD, Chronic obstructive pulmonary disease; CRTH2, Chemoattractant receptor expressed on Th2 cells; Eomes, Eomesodermin; FALC, ...
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Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft versus host disease
... stem cell transplantation has found that elevation of ST2 was associated with a lack of therapeutic response for GVHD on day 28 after transplant and increased mortality 6 months after transplan- tation ...our ...
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Regulation of Tissue Homeostasis by Innate Lymphoid Cells
... similar cell types across multiple laboratories, the current dogma classifies ILCs into three main subsets, ILC1, ILC2 and ILC3 (Spits et ...of cell surface markers characteristic of the Group ...
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MicroRNA 155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type 2 Immunity
... was upregulated in Th2 cells as well as the cells around the intestinal lesions during an H. polygyrus infection (19). MiR- 155-deficient mice also had significantly lower IL-13 expression and airway mucus in response to ...
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Tissue Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
... Treg cell accumulation following IL-33 administration (Molofsky et ...T cell receptor (TCR)-mediated activation, while OX40L expres- sion is reported on numerous immune cells but most notably on ...
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T bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function
... acting as a direct transcriptional repressor of IL-7R α , rather than indirectly via a change in GATA-3 expression. Increased IL-7 responsiveness in the absence of retinoic acid signalling has been related to higher ILC2 ...
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Lymphoid-Tissue Stromal Cells Coordinate Innate Defense to Cytomegalovirus
... upon cell-intrinsic STAT4 signal- ing (10, 18). As NK cell activation during the first 12 h of infection is strictly dependent upon IFN-IR (as assessed by NK cell induc- tion of CD69), this raised ...
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Interleukin-22 Regulates Immunity, Inflammation and Tissue Homeostasis at Mucosal Sites
... Chapter 2 and Chapter 3 in which IL-22-producing ILCs but not Th17 cells are essential in promoting IL-22- dependent intestinal immunity and ...versus cell populations that express either of the ...
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The balance of power: innate lymphoid cells in tissue inflammation and repair
... Recent advances in cellular and molecular immunology have revealed the existence of a broad class of innate lymphoid cells (ILCs). ILCs are evolutionarily ancient cells, present in common ancestors of both ...
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